SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jwj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 152
SER A 116
ASN A 117
THR A 248
 None
None
None
SAH  A 302 ( 4.4A)
 1.10A 1ig3A-4jwjA:
undetectable
1ig3B-4jwjA:
undetectable		 1ig3A-4jwjA:
22.71
1ig3B-4jwjA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 205
GLY A 206
LEU A 232
LEU A 246
THR A 248
 SAH  A 302 (-3.6A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.8A)
SAH  A 302 (-4.2A)
SAH  A 302 ( 4.4A)
 0.56A 2egvA-4jwjA:
9.0		 2egvA-4jwjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 205
GLY A 206
LEU A 232
LEU A 246
THR A 248
 SAH  A 302 (-3.6A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.8A)
SAH  A 302 (-4.2A)
SAH  A 302 ( 4.4A)
 0.58A 2egvB-4jwjA:
8.8		 2egvB-4jwjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 186
VAL A 205
GLY A 206
LEU A 232
LEU A 246
 SAH  A 302 (-4.2A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.8A)
SAH  A 302 (-4.2A)
 0.71A 2v3kA-4jwjA:
7.0		 2v3kA-4jwjA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 127
ILE A 135
VAL A 252
LEU A 256
 TRS  A 303 (-3.0A)
None
None
None
 1.10A 4em2A-4jwjA:
undetectable		 4em2A-4jwjA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		3 / 3 MET A 107
GLU A 111
LEU A 115
 None
 0.78A 4v2oB-4jwjA:
undetectable		 4v2oB-4jwjA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 112
GLN A 146
ARG A 143
GLU A 149
 None
 1.50A 5fseC-4jwjA:
undetectable		 5fseC-4jwjA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 206
GLU A 149
ALA A 122
ILE A 112
MET A 107
 SAH  A 302 (-3.1A)
None
None
None
None
 1.01A 5igyA-4jwjA:
undetectable		 5igyA-4jwjA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 186
ALA A 188
GLY A 206
ASP A 210
LEU A 232
LEU A 246
 SAH  A 302 (-4.2A)
SAH  A 302 (-3.5A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.0A)
SAH  A 302 (-3.8A)
SAH  A 302 (-4.2A)
 0.70A 5nfjB-4jwjA:
23.5		 5nfjB-4jwjA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 186
ALA A 188
GLY A 206
ASP A 210
LEU A 232
LEU A 246
 SAH  A 302 (-4.2A)
SAH  A 302 (-3.5A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.0A)
SAH  A 302 (-3.8A)
SAH  A 302 (-4.2A)
 0.72A 5nfjC-4jwjA:
23.2		 5nfjC-4jwjA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 186
GLY A 206
LEU A 232
VAL A 245
THR A 248
 SAH  A 302 (-4.2A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.8A)
SAH  A 302 ( 3.9A)
SAH  A 302 ( 4.4A)
 0.92A 5o96G-4jwjA:
8.7		 5o96G-4jwjA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 206
LEU A 232
VAL A 245
LEU A 246
THR A 248
 SAH  A 302 (-3.1A)
SAH  A 302 (-3.8A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-4.2A)
SAH  A 302 ( 4.4A)
 0.73A 5o96G-4jwjA:
8.8
5o96H-4jwjA:
9.3		 5o96G-4jwjA:
20.80
5o96H-4jwjA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 186
GLY A 206
LEU A 232
VAL A 245
THR A 248
 SAH  A 302 (-4.2A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.8A)
SAH  A 302 ( 3.9A)
SAH  A 302 ( 4.4A)
 0.82A 5o96G-4jwjA:
8.8
5o96H-4jwjA:
9.3		 5o96G-4jwjA:
20.80
5o96H-4jwjA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 186
GLY A 206
LEU A 232
LEU A 246
VAL A 251
 SAH  A 302 (-4.2A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.8A)
SAH  A 302 (-4.2A)
SAH  A 302 (-4.8A)
 0.47A 5twjA-4jwjA:
4.2		 5twjA-4jwjA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 186
GLY A 206
LEU A 232
LEU A 246
VAL A 251
 SAH  A 302 (-4.2A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.8A)
SAH  A 302 (-4.2A)
SAH  A 302 (-4.8A)
 0.45A 5twjB-4jwjA:
5.2		 5twjB-4jwjA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 186
GLY A 206
LEU A 232
LEU A 246
VAL A 251
 SAH  A 302 (-4.2A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.8A)
SAH  A 302 (-4.2A)
SAH  A 302 (-4.8A)
 0.48A 5twjC-4jwjA:
5.2		 5twjC-4jwjA:
24.88