SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwo PHOSPHATE BINDING
PROTEIN
(Planctopirus
limnophila) 		5 / 11 THR A  95
GLY A 111
GLU A 120
SER A  65
ILE A 285
 SO4  A 401 (-3.6A)
None
None
SO4  A 401 (-2.9A)
None
 1.30A 1odiD-4jwoA:
undetectable		 1odiD-4jwoA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4jwo PHOSPHATE BINDING
PROTEIN
(Planctopirus
limnophila) 		4 / 4 LEU A 160
PRO A 181
ILE A 145
LEU A 235
 None
 0.81A 1ya4B-4jwoA:
undetectable		 1ya4B-4jwoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4jwo PHOSPHATE BINDING
PROTEIN
(Planctopirus
limnophila) 		4 / 4 LEU A 160
PRO A 181
ILE A 145
LEU A 235
 None
 0.73A 1ya4C-4jwoA:
undetectable		 1ya4C-4jwoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4jwo PHOSPHATE BINDING
PROTEIN
(Planctopirus
limnophila) 		4 / 6 SER A  65
ALA A 112
SER A 113
THR A  67
 SO4  A 401 (-2.9A)
None
SO4  A 401 (-2.2A)
SO4  A 401 ( 4.9A)
 1.15A 1yvpB-4jwoA:
undetectable		 1yvpB-4jwoA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 4jwo PHOSPHATE BINDING
PROTEIN
(Planctopirus
limnophila) 		5 / 10 TYR A 318
ALA A 137
PRO A 268
GLU A 272
ILE A 271
 None
None
PEG  A 406 (-4.1A)
None
None
 1.39A 2dm6A-4jwoA:
undetectable
2dm6B-4jwoA:
undetectable		 2dm6A-4jwoA:
23.99
2dm6B-4jwoA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4jwo PHOSPHATE BINDING
PROTEIN
(Planctopirus
limnophila) 		5 / 12 VAL A 136
ILE A 301
THR A 287
LYS A 291
VAL A  75
 None
 1.26A 2jn3A-4jwoA:
undetectable		 2jn3A-4jwoA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4jwo PHOSPHATE BINDING
PROTEIN
(Planctopirus
limnophila) 		3 / 3 SER A 194
GLY A 195
THR A 196
 None
 0.19A 3k9wA-4jwoA:
undetectable		 3k9wA-4jwoA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jwo PHOSPHATE BINDING
PROTEIN
(Planctopirus
limnophila) 		5 / 11 THR A  95
GLY A 111
GLU A 120
SER A  65
ILE A 285
 SO4  A 401 (-3.6A)
None
None
SO4  A 401 (-2.9A)
None
 1.23A 3uawA-4jwoA:
undetectable		 3uawA-4jwoA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4jwo PHOSPHATE BINDING
PROTEIN
(Planctopirus
limnophila) 		4 / 7 VAL A  68
ILE A  71
LEU A 333
LEU A 305
 None
 0.99A 4l1wA-4jwoA:
undetectable		 4l1wA-4jwoA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4jwo PHOSPHATE BINDING
PROTEIN
(Planctopirus
limnophila) 		5 / 12 LEU A 304
PHE A 300
ILE A  71
GLY A 111
ILE A  60
 None
 1.00A 4nkxC-4jwoA:
undetectable		 4nkxC-4jwoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4jwo PHOSPHATE BINDING
PROTEIN
(Planctopirus
limnophila) 		5 / 12 LEU A 304
PHE A 300
ILE A  71
GLY A 111
ILE A  60
 None
 0.96A 4nkxD-4jwoA:
undetectable		 4nkxD-4jwoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4jwo PHOSPHATE BINDING
PROTEIN
(Planctopirus
limnophila) 		3 / 3 TYR A 286
THR A 288
THR A 110
 None
 0.82A 5aoxB-4jwoA:
undetectable		 5aoxB-4jwoA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 4jwo PHOSPHATE BINDING
PROTEIN
(Planctopirus
limnophila) 		4 / 6 VAL A 109
ILE A  60
GLU A 296
ARG A 294
 None
 1.07A 5z3jA-4jwoA:
undetectable		 5z3jA-4jwoA:
21.70