SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jwp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 12 ALA A   8
ASP A  12
ILE A  98
ILE A   5
THR A   9
 None
None
ACO  A 201 (-4.4A)
None
None
 1.15A 1d1gA-4jwpA:
undetectable		 1d1gA-4jwpA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 12 ALA A   8
ASP A  12
ILE A  98
ILE A   5
THR A   9
 None
None
ACO  A 201 (-4.4A)
None
None
 1.21A 1d1gB-4jwpA:
undetectable		 1d1gB-4jwpA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 10 ALA A   8
ASP A  12
ILE A  98
ILE A   5
THR A   9
 None
None
ACO  A 201 (-4.4A)
None
None
 1.10A 1j3jA-4jwpA:
undetectable		 1j3jA-4jwpA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 9 ALA A   8
ASP A  12
ILE A  98
ILE A   5
THR A   9
 None
None
ACO  A 201 (-4.4A)
None
None
 1.16A 1j3jB-4jwpA:
undetectable		 1j3jB-4jwpA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 12 GLY A 137
LEU A 164
ARG A 111
CYH A 141
ILE A 122
 None
None
None
None
ACO  A 201 (-4.0A)
 1.44A 1p93B-4jwpA:
undetectable		 1p93B-4jwpA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 10 ALA A   8
ASP A  12
ILE A  98
ILE A   5
THR A   9
 None
None
ACO  A 201 (-4.4A)
None
None
 1.24A 1rb3A-4jwpA:
undetectable		 1rb3A-4jwpA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 12 ALA A   8
ASP A  12
ILE A  98
ILE A   5
THR A   9
 None
None
ACO  A 201 (-4.4A)
None
None
 1.15A 2bl9A-4jwpA:
undetectable		 2bl9A-4jwpA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 11 ALA A   8
ASP A  12
ILE A  98
ILE A   5
THR A   9
 None
None
ACO  A 201 (-4.4A)
None
None
 1.08A 3clbA-4jwpA:
undetectable		 3clbA-4jwpA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 10 ALA A   8
ASP A  12
ILE A  98
ILE A   5
THR A   9
 None
None
ACO  A 201 (-4.4A)
None
None
 1.06A 3clbD-4jwpA:
undetectable		 3clbD-4jwpA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 10 ALA A   8
ASP A  12
ILE A  98
ILE A   5
THR A   9
 None
None
ACO  A 201 (-4.4A)
None
None
 1.06A 3hbbD-4jwpA:
undetectable		 3hbbD-4jwpA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 10 ALA A   8
ASP A  12
ILE A  98
ILE A   5
THR A   9
 None
None
ACO  A 201 (-4.4A)
None
None
 1.13A 3qgtA-4jwpA:
undetectable		 3qgtA-4jwpA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 10 ALA A   8
ASP A  12
ILE A  98
ILE A   5
THR A   9
 None
None
ACO  A 201 (-4.4A)
None
None
 1.17A 3qgtB-4jwpA:
undetectable		 3qgtB-4jwpA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 12 ALA A   8
ASP A  12
ILE A  98
ILE A   5
THR A   9
 None
None
ACO  A 201 (-4.4A)
None
None
 1.25A 3ql3A-4jwpA:
undetectable		 3ql3A-4jwpA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		5 / 9 ALA A   8
ASP A  12
ILE A  98
ILE A   5
THR A   9
 None
None
ACO  A 201 (-4.4A)
None
None
 1.17A 3tq8A-4jwpA:
undetectable		 3tq8A-4jwpA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		4 / 7 ASN A 126
ALA A 128
SER A 129
VAL A  87
 ACO  A 201 (-3.4A)
ACO  A 201 (-3.4A)
ACO  A 201 (-3.2A)
ACO  A 201 (-4.2A)
 1.06A 4ijiH-4jwpA:
undetectable		 4ijiH-4jwpA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4jwp GCN5-RELATED
N-ACETYLTRANSFERASE
(Brucella
abortus) 		4 / 7 GLU A  59
ILE A   5
LEU A 132
ILE A  98
 None
None
ACO  A 201 ( 4.2A)
ACO  A 201 (-4.4A)
 0.92A 4xumA-4jwpA:
undetectable		 4xumA-4jwpA:
21.99