SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jwq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 4jwq CALCIUM-DEPENDENT
PROTEIN KINASE
(Plasmodium
berghei) 		5 / 9 ILE A 145
LEU A 150
MET A 174
GLU A 177
MET A 194
 None
 0.68A 1ctrA-4jwqA:
11.3		 1ctrA-4jwqA:
30.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4jwq CALCIUM-DEPENDENT
PROTEIN KINASE
(Plasmodium
berghei) 		5 / 11 ILE A 145
LEU A 150
MET A 174
VAL A 178
MET A 194
 None
 0.72A 1dtlA-4jwqA:
10.4		 1dtlA-4jwqA:
27.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 4jwq CALCIUM-DEPENDENT
PROTEIN KINASE
(Plasmodium
berghei) 		5 / 11 GLY A 143
ASP A 142
THR A 146
ILE A 145
ARG A 135
 None
CA  A 201 (-2.9A)
CA  A 201 ( 4.9A)
None
None
 1.35A 2f9wA-4jwqA:
undetectable
2f9wB-4jwqA:
undetectable		 2f9wA-4jwqA:
24.09
2f9wB-4jwqA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 4jwq CALCIUM-DEPENDENT
PROTEIN KINASE
(Plasmodium
berghei) 		4 / 8 ILE A 145
LEU A 150
MET A 174
MET A 194
 None
 0.63A 4rjdA-4jwqA:
11.6		 4rjdA-4jwqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 4jwq CALCIUM-DEPENDENT
PROTEIN KINASE
(Plasmodium
berghei) 		4 / 7 LEU A 150
MET A 174
MET A 194
MET A 195
 None
 0.60A 4rjdB-4jwqA:
11.2		 4rjdB-4jwqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 4jwq CALCIUM-DEPENDENT
PROTEIN KINASE
(Plasmodium
berghei) 		4 / 7 PHE A 137
LEU A 150
MET A 194
MET A 195
 None
 0.71A 4rjdB-4jwqA:
11.2		 4rjdB-4jwqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4jwq CALCIUM-DEPENDENT
PROTEIN KINASE
(Plasmodium
berghei) 		5 / 10 LEU A 150
MET A 174
VAL A 178
ILE A 186
MET A 195
 None
 0.71A 5v02B-4jwqA:
undetectable
5v02R-4jwqA:
11.2		 5v02B-4jwqA:
21.57
5v02R-4jwqA:
31.22