SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		6 / 12 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
ADE  A 305 (-2.8A)
 0.56A 1jdvE-4jwtA:
22.7
1jdvF-4jwtA:
22.1		 1jdvE-4jwtA:
22.22
1jdvF-4jwtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
 0.47A 1odiA-4jwtA:
16.6		 1odiA-4jwtA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
 0.54A 1odiB-4jwtA:
24.5		 1odiB-4jwtA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
 0.51A 1odiC-4jwtA:
24.3		 1odiC-4jwtA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
 0.52A 1odiD-4jwtA:
24.5		 1odiD-4jwtA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
 0.54A 1odiE-4jwtA:
24.5		 1odiE-4jwtA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
 0.52A 1odiF-4jwtA:
24.3		 1odiF-4jwtA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		6 / 9 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
ADE  A 305 (-2.8A)
 0.63A 1pk7A-4jwtA:
23.1		 1pk7A-4jwtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		6 / 10 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
ADE  A 305 (-2.8A)
 0.52A 1pk7C-4jwtA:
24.0		 1pk7C-4jwtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		6 / 10 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
ADE  A 305 (-2.8A)
 0.54A 1pk9A-4jwtA:
23.1		 1pk9A-4jwtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		6 / 9 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
ADE  A 305 (-2.8A)
 0.54A 1pk9B-4jwtA:
23.2		 1pk9B-4jwtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		6 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
ADE  A 305 (-2.8A)
 0.41A 1pk9C-4jwtA:
24.1		 1pk9C-4jwtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		6 / 10 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
ADE  A 305 (-2.8A)
 0.63A 1pw7A-4jwtA:
23.1		 1pw7A-4jwtA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 9 GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
ADE  A 305 (-2.8A)
 0.56A 1pw7C-4jwtA:
23.9		 1pw7C-4jwtA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 10 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
 0.64A 1z35A-4jwtA:
22.8		 1z35A-4jwtA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 9 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
 0.49A 1z37A-4jwtA:
22.7		 1z37A-4jwtA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-2.8A)
 0.46A 2ac7A-4jwtA:
22.6
2ac7B-4jwtA:
22.6		 2ac7A-4jwtA:
22.93
2ac7B-4jwtA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-2.8A)
 0.46A 2ac7A-4jwtA:
22.6
2ac7B-4jwtA:
22.6		 2ac7A-4jwtA:
22.93
2ac7B-4jwtA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 9 LEU A  72
ILE A 221
PHE A 189
ARG A 192
ILE A 190
 None
 1.04A 2f7aB-4jwtA:
undetectable		 2f7aB-4jwtA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		4 / 7 MET A   9
ARG A 192
ILE A  13
GLU A  11
 None
 1.46A 2nsiA-4jwtA:
undetectable
2nsiB-4jwtA:
undetectable		 2nsiA-4jwtA:
21.78
2nsiB-4jwtA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		4 / 7 GLU A  11
MET A   9
ARG A 192
ILE A  13
 None
 1.45A 2nsiA-4jwtA:
undetectable
2nsiB-4jwtA:
undetectable		 2nsiA-4jwtA:
21.78
2nsiB-4jwtA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		4 / 7 MET A   9
ARG A 192
ILE A  13
GLU A  11
 None
 1.46A 2nsiC-4jwtA:
undetectable
2nsiD-4jwtA:
undetectable		 2nsiC-4jwtA:
21.78
2nsiD-4jwtA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		4 / 7 GLU A  11
MET A   9
ARG A 192
ILE A  13
 None
 1.46A 2nsiC-4jwtA:
undetectable
2nsiD-4jwtA:
undetectable		 2nsiC-4jwtA:
21.78
2nsiD-4jwtA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 12 GLY A   7
GLY A  75
GLU A  12
ALA A  46
GLU A 171
 None
 1.12A 2vdvE-4jwtA:
undetectable		 2vdvE-4jwtA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 11 GLY A   7
GLY A  75
GLU A  12
ALA A  46
GLU A 171
 None
 1.13A 2vdvF-4jwtA:
undetectable		 2vdvF-4jwtA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 12 THR A 147
GLY A 178
GLY A 174
ALA A  92
ALA A  56
 None
 1.09A 2yvlB-4jwtA:
undetectable		 2yvlB-4jwtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 12 THR A 147
GLY A 178
GLY A 174
ALA A  92
ALA A  56
 None
 1.04A 2yvlD-4jwtA:
undetectable		 2yvlD-4jwtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		4 / 7 MET A   9
ARG A 192
ILE A  13
GLU A  11
 None
 1.46A 3e7gA-4jwtA:
undetectable
3e7gB-4jwtA:
undetectable		 3e7gA-4jwtA:
21.58
3e7gB-4jwtA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		4 / 7 GLU A  11
MET A   9
ARG A 192
ILE A  13
 None
 1.49A 3e7gA-4jwtA:
undetectable
3e7gB-4jwtA:
undetectable		 3e7gA-4jwtA:
21.58
3e7gB-4jwtA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		4 / 8 GLU A  11
MET A   9
ARG A 192
ILE A  13
 None
 1.45A 3e7gC-4jwtA:
undetectable
3e7gD-4jwtA:
undetectable		 3e7gC-4jwtA:
21.58
3e7gD-4jwtA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 12 GLY A   7
SER A  48
ALA A  56
ALA A  59
CYH A 181
 None
 1.10A 3keeA-4jwtA:
undetectable		 3keeA-4jwtA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 12 GLY A   7
ILE A  13
LEU A 210
GLU A 171
VAL A  76
 None
None
None
None
ADE  A 305 (-4.8A)
 1.08A 3o7wA-4jwtA:
undetectable		 3o7wA-4jwtA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		4 / 5 ASP A 196
SER A 195
VAL A  76
GLY A  78
 ADE  A 305 (-2.8A)
ADE  A 305 (-3.2A)
ADE  A 305 (-4.8A)
ADE  A 305 (-3.6A)
 1.02A 3rxhA-4jwtA:
undetectable		 3rxhA-4jwtA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 12 GLY A  78
GLU A 171
MET A 172
GLU A 173
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-2.8A)
 0.44A 3u40B-4jwtA:
22.8
3u40C-4jwtA:
22.8		 3u40B-4jwtA:
23.64
3u40C-4jwtA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-2.8A)
 0.46A 3u40D-4jwtA:
23.0
3u40E-4jwtA:
22.8		 3u40D-4jwtA:
23.64
3u40E-4jwtA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 12 GLY A  78
GLU A 171
MET A 172
GLU A 173
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-2.8A)
 0.43A 3u40D-4jwtA:
23.0
3u40E-4jwtA:
22.8		 3u40D-4jwtA:
23.64
3u40E-4jwtA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		6 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
ADE  A 305 (-2.8A)
 0.44A 3uawA-4jwtA:
23.5		 3uawA-4jwtA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 12 ILE A  90
LEU A 170
LEU A  84
ILE A  80
ILE A 190
 None
ADE  A 305 (-4.7A)
None
None
None
 1.01A 3vrmA-4jwtA:
undetectable		 3vrmA-4jwtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 12 LEU A 210
GLY A  75
ILE A  13
PHE A  73
ALA A  77
 None
None
None
None
ADE  A 305 (-4.8A)
 1.13A 4a6dA-4jwtA:
undetectable		 4a6dA-4jwtA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
 0.45A 4d9hA-4jwtA:
23.4		 4d9hA-4jwtA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 10 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
 0.45A 4da7A-4jwtA:
23.5		 4da7A-4jwtA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
 0.42A 4danA-4jwtA:
23.0		 4danA-4jwtA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		6 / 12 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
ADE  A 305 (-2.8A)
 0.76A 4danA-4jwtA:
23.0
4danB-4jwtA:
23.2		 4danA-4jwtA:
27.46
4danB-4jwtA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 12 GLY A 174
SER A  55
ALA A   4
CYH A 181
ILE A  63
 None
 1.13A 4krhB-4jwtA:
undetectable		 4krhB-4jwtA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE
(Sulfurimonas
denitrificans) 		5 / 11 GLY A  78
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 305 (-3.6A)
None
ADE  A 305 (-4.1A)
None
ADE  A 305 (-3.2A)
 0.54A 5i3cC-4jwtA:
23.4		 5i3cC-4jwtA:
22.68