SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jwv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4jwv SHORT CHAIN
ENOYL-COA HYDRATASE
(Novosphingobium
aromaticivorans) 		4 / 8 PRO A 201
ALA A 203
ALA A 206
THR A 236
 None
 0.84A 3dtuC-4jwvA:
undetectable
3dtuD-4jwvA:
undetectable		 3dtuC-4jwvA:
19.51
3dtuD-4jwvA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 4jwv SHORT CHAIN
ENOYL-COA HYDRATASE
(Novosphingobium
aromaticivorans) 		4 / 5 LEU A 150
ALA A 170
PHE A 127
ASN A 177
 None
 1.11A 3uq6A-4jwvA:
undetectable		 3uq6A-4jwvA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 4jwv SHORT CHAIN
ENOYL-COA HYDRATASE
(Novosphingobium
aromaticivorans) 		4 / 4 LEU A 150
ALA A 170
PHE A 127
ASN A 177
 None
 1.15A 3vaqA-4jwvA:
undetectable		 3vaqA-4jwvA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 4jwv SHORT CHAIN
ENOYL-COA HYDRATASE
(Novosphingobium
aromaticivorans) 		4 / 4 LEU A 150
ALA A 170
PHE A 127
ASN A 177
 None
 1.11A 3vasA-4jwvA:
undetectable		 3vasA-4jwvA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 4jwv SHORT CHAIN
ENOYL-COA HYDRATASE
(Novosphingobium
aromaticivorans) 		5 / 11 LEU A 185
VAL A 120
PHE A 127
ALA A 113
PHE A  61
 None
 1.31A 4evrA-4jwvA:
2.5		 4evrA-4jwvA:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4jwv SHORT CHAIN
ENOYL-COA HYDRATASE
(Novosphingobium
aromaticivorans) 		5 / 10 VAL A 176
ALA A  99
CYH A 115
ALA A 116
ILE A 119
 None
 0.96A 4lbgA-4jwvA:
undetectable		 4lbgA-4jwvA:
30.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4jwv SHORT CHAIN
ENOYL-COA HYDRATASE
(Novosphingobium
aromaticivorans) 		5 / 9 VAL A 176
ALA A  99
CYH A 115
ALA A 116
ILE A 119
 None
 0.95A 4lbgB-4jwvA:
undetectable		 4lbgB-4jwvA:
30.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4jwv SHORT CHAIN
ENOYL-COA HYDRATASE
(Novosphingobium
aromaticivorans) 		4 / 4 ALA A 203
ALA A 206
ALA A 207
ALA A 210
 None
 0.12A 4oadA-4jwvA:
undetectable		 4oadA-4jwvA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4jwv SHORT CHAIN
ENOYL-COA HYDRATASE
(Novosphingobium
aromaticivorans) 		4 / 4 ALA A 203
ALA A 206
ALA A 207
ALA A 210
 None
 0.11A 4oaeA-4jwvA:
undetectable		 4oaeA-4jwvA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4jwv SHORT CHAIN
ENOYL-COA HYDRATASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLN A 149
GLY A 107
LEU A 112
GLY A 109
GLY A 108
 None
 0.97A 5wyqB-4jwvA:
undetectable		 5wyqB-4jwvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4jwv SHORT CHAIN
ENOYL-COA HYDRATASE
(Novosphingobium
aromaticivorans) 		5 / 12 PHE A 110
GLY A 108
LEU A  53
ILE A  27
LEU A 175
 None
 1.02A 5y2tA-4jwvA:
undetectable		 5y2tA-4jwvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4jwv SHORT CHAIN
ENOYL-COA HYDRATASE
(Novosphingobium
aromaticivorans) 		4 / 4 GLY A 107
LEU A 129
VAL A 142
GLU A 111
 None
 1.24A 5yw0A-4jwvA:
undetectable		 5yw0A-4jwvA:
22.58