SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jwx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1PB9_A_4AXA901_1 (N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT 1)	4jwx	GLUN2A (Rattus norvegicus)	5 / 9	LEU A 115 THR A 116 ARG A 121 SER A 173 ASP A 215	1N4 A 301 ( 4.9A) 1N4 A 301 (-3.5A) 1N4 A 301 (-2.9A) 1N4 A 301 (-2.3A) 1N4 A 301 ( 4.1A)	0.75A	1pb9A-4jwxA: 32.8	1pb9A-4jwxA: 36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DG9_A_RAPA501_1 (FK506-BINDING PROTEIN 1A)	4jwx	GLUN2A (Rattus norvegicus)	5 / 11	VAL A 109 ILE A 11 LEU A 9 ILE A 66 PHE A 76	None	0.91A	2dg9A-4jwxA: undetectable	2dg9A-4jwxA: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EM2_A_SALA504_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	4jwx	GLUN2A (Rattus norvegicus)	4 / 8	PHE A 76 LEU A 67 ILE A 66 ILE A 247	None	0.68A	4em2A-4jwxA: undetectable	4em2A-4jwxA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G0V_D_MIXD101_1 (DNA TOPOISOMERASE 2-BETA)	4jwx	GLUN2A (Rattus norvegicus)	4 / 6	ARG A 176 GLY A 172 ASN A 193 GLU A 175	None 1N4 A 301 (-3.5A) None None	1.24A	4g0vB-4jwxA: undetectable	4g0vB-4jwxA: 16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_G_377G401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	4jwx	GLUN2A (Rattus norvegicus)	4 / 6	TYR A 245 GLU A 16 TYR A 214 LEU A 219	None 1N4 A 301 ( 4.4A) 1N4 A 301 (-4.2A) None	1.34A	4twdF-4jwxA: undetectable 4twdG-4jwxA: undetectable	4twdF-4jwxA: 21.21 4twdG-4jwxA: 21.21

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1PB9_A_4AXA901_1","N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT 1","4jwx","GLUN2A","Rattus norvegicus",5,"LEU A 115;THR A 116;ARG A 121;SER A 173;ASP A 215","1N4 A 301 ( 4.9A);1N4 A 301 (-3.5A);1N4 A 301 (-2.9A);1N4 A 301 (-2.3A);1N4 A 301 ( 4.1A)","0.75A","1pb9A-4jwxA:32.8","1pb9A-4jwxA:36.67"],["2DG9_A_RAPA501_1","FK506-BINDING PROTEIN 1A","4jwx","GLUN2A","Rattus norvegicus",5,"VAL A 109;ILE A  11;LEU A   9;ILE A  66;PHE A  76","None","0.91A","2dg9A-4jwxA:undetectable","2dg9A-4jwxA:18.45"],["4EM2_A_SALA504_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","4jwx","GLUN2A","Rattus norvegicus",4,"PHE A  76;LEU A  67;ILE A  66;ILE A 247","None","0.68A","4em2A-4jwxA:undetectable","4em2A-4jwxA:20.00"],["4G0V_D_MIXD101_1","DNA TOPOISOMERASE 2-BETA","4jwx","GLUN2A","Rattus norvegicus",4,"ARG A 176;GLY A 172;ASN A 193;GLU A 175","None;1N4 A 301 (-3.5A);None;None","1.24A","4g0vB-4jwxA:undetectable","4g0vB-4jwxA:16.63"],["4TWD_G_377G401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","4jwx","GLUN2A","Rattus norvegicus",4,"TYR A 245;GLU A  16;TYR A 214;LEU A 219","None;1N4 A 301 ( 4.4A);1N4 A 301 (-4.2A);None","1.34A","4twdF-4jwxA:undetectable;4twdG-4jwxA:undetectable","4twdF-4jwxA:21.21;4twdG-4jwxA:21.21"]]