SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		5 / 12 ALA A 108
LYS A   5
ILE A 259
LEU A  70
ILE A 112
 None
 1.25A 1d1gA-4jwyA:
undetectable		 1d1gA-4jwyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		5 / 10 LEU A 264
ASP A 260
ILE A 112
GLY A 246
ILE A 117
 None
 1.09A 1d4yA-4jwyA:
undetectable		 1d4yA-4jwyA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		4 / 5 LEU A 204
MET A 222
LEU A 219
GLN A 194
 None
 1.49A 1p93D-4jwyA:
undetectable		 1p93D-4jwyA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PB9_A_4AXA901_1
(N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT 1)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		5 / 9 LEU A 115
THR A 116
ARG A 121
SER A 173
ASP A 215
 1N4  A 301 ( 4.9A)
1N4  A 301 (-3.6A)
1N4  A 301 (-2.9A)
1N4  A 301 (-2.1A)
1N4  A 301 ( 4.5A)
 0.75A 1pb9A-4jwyA:
33.5		 1pb9A-4jwyA:
33.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		5 / 10 LEU A 264
ASP A 260
ILE A 112
GLY A 246
ILE A 117
 None
 0.99A 1sdtA-4jwyA:
undetectable		 1sdtA-4jwyA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		5 / 11 LEU A 264
ASP A 260
ILE A 112
GLY A 246
ILE A 117
 None
 0.97A 1sduA-4jwyA:
undetectable		 1sduA-4jwyA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		5 / 9 LEU A 264
ASP A 260
ILE A 112
GLY A 246
ILE A 117
 None
 1.01A 2avoA-4jwyA:
undetectable		 2avoA-4jwyA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		5 / 12 THR A 168
GLY A 167
TYR A 192
PHE A 166
ARG A 191
 None
 1.25A 2y7kC-4jwyA:
8.2		 2y7kC-4jwyA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		5 / 9 LEU A 264
ASP A 260
ILE A 112
GLY A 246
ILE A 117
 None
 1.07A 3d1yB-4jwyA:
undetectable		 3d1yB-4jwyA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		4 / 6 THR A 134
THR A 243
ILE A 136
THR A 116
 None
None
None
1N4  A 301 (-3.6A)
 0.97A 3deuB-4jwyA:
undetectable		 3deuB-4jwyA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		5 / 9 LEU A 264
ASP A 260
ILE A 112
GLY A 246
ILE A 117
 None
 1.02A 3ekqB-4jwyA:
undetectable		 3ekqB-4jwyA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		5 / 12 LEU A 264
ASP A 260
ILE A 112
GLY A 246
ILE A 117
 None
 0.96A 3ndtC-4jwyA:
undetectable		 3ndtC-4jwyA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		4 / 5 ILE A 136
ARG A 121
THR A 116
GLU A  14
 None
1N4  A 301 (-2.9A)
1N4  A 301 (-3.6A)
1N4  A 301 ( 4.9A)
 1.16A 3ny4A-4jwyA:
undetectable		 3ny4A-4jwyA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		4 / 8 ALA A 248
ILE A 100
LEU A 115
ALA A  10
 None
None
1N4  A 301 ( 4.9A)
None
 0.73A 3r9tA-4jwyA:
undetectable		 3r9tA-4jwyA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		4 / 8 PHE A  76
LEU A  67
ILE A  66
ILE A 247
 None
 0.86A 4em2A-4jwyA:
undetectable		 4em2A-4jwyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		4 / 8 PHE A 127
GLY A 246
LEU A 115
THR A 243
 None
None
1N4  A 301 ( 4.9A)
None
 0.87A 4em2A-4jwyA:
undetectable		 4em2A-4jwyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		4 / 8 ALA A 262
ASP A  65
ILE A  66
ILE A 112
 None
 0.90A 4kttD-4jwyA:
undetectable		 4kttD-4jwyA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		4 / 6 ILE A 259
ASP A 260
GLY A 246
VAL A 132
 None
 0.93A 4oltA-4jwyA:
undetectable		 4oltA-4jwyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		4 / 6 ILE A 259
ASP A 260
GLY A 246
VAL A 132
 None
 0.92A 4oltB-4jwyA:
undetectable		 4oltB-4jwyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4jwy GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2D
(Rattus
norvegicus) 		4 / 5 ILE A 213
GLN A 194
THR A 168
LEU A 164
 None
 1.12A 6f3mD-4jwyA:
undetectable		 6f3mD-4jwyA:
19.11