SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jx0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4jx0 HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		5 / 12 PRO A 129
ASN A 132
LEU A 153
VAL A 191
TYR A  70
 None
 1.28A 1u72A-4jx0A:
undetectable		 1u72A-4jx0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4jx0 HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 7 GLY A 296
SER A 280
SER A 204
ARG A 198
 None
 0.98A 2c8aB-4jx0A:
undetectable		 2c8aB-4jx0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4jx0 HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 7 GLY A 296
SER A 280
SER A 204
ARG A 198
 None
 0.84A 2c8aD-4jx0A:
undetectable		 2c8aD-4jx0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 4jx0 HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		5 / 12 ASN A 201
ASP A 203
VAL A 283
ILE A 309
GLY A 263
 None
 0.95A 3spkB-4jx0A:
undetectable		 3spkB-4jx0A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4jx0 HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 8 ARG A 265
GLU A 210
ILE A 209
ASN A 206
 None
 1.09A 4d39A-4jx0A:
undetectable		 4d39A-4jx0A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4jx0 HYPOTHETICAL PROTEIN
(Bacteroides
fragilis) 		4 / 5 ILE A 253
PHE A 220
ARG A 265
THR A 268
 None
 1.27A 5z84N-4jx0A:
undetectable
5z84W-4jx0A:
undetectable		 5z84N-4jx0A:
21.01
5z84W-4jx0A:
16.76