SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jx2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 4jx2 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 12 ILE A 140
TYR A 247
LEU A 237
PHE A 236
LEU A 232
 None
 1.01A 2mjiA-4jx2A:
undetectable		 2mjiA-4jx2A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4jx2 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 8 ILE A 252
GLY A 253
LEU A 257
LEU A 260
 None
 0.78A 2vctA-4jx2A:
3.2		 2vctA-4jx2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 4jx2 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 7 LEU A 397
GLU A 391
MET A 148
TYR A 247
 None
 1.24A 2w8yA-4jx2A:
undetectable		 2w8yA-4jx2A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 4jx2 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 6 SER A 231
VAL A 220
TYR A 216
ASP A 228
 None
 1.34A 2x45A-4jx2A:
undetectable		 2x45A-4jx2A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4jx2 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 6 MET A 256
GLY A 413
TRP A 415
GLU A 419
 None
 1.44A 4bqfA-4jx2A:
undetectable		 4bqfA-4jx2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4jx2 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		6 / 12 GLY A 133
MET A 137
LEU A 257
ASN A 191
VAL A 190
LEU A 187
 None
 1.42A 4fr0A-4jx2A:
undetectable		 4fr0A-4jx2A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jx2 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		3 / 3 VAL A 190
LEU A 420
MET A 263
 None
 0.77A 5ikrA-4jx2A:
undetectable		 5ikrA-4jx2A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 4jx2 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		5 / 12 LEU A 168
MET A 165
LEU A 169
LEU A 221
LEU A 232
 None
 1.27A 5toaB-4jx2A:
undetectable		 5toaB-4jx2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4jx2 HYPOTHETICAL PROTEIN
(Legionella
pneumophila) 		4 / 9 ILE A 178
ILE A 206
ILE A 202
LEU A 199
 None
None
None
PEG  A 511 ( 4.4A)
 0.69A 5vkqB-4jx2A:
2.8
5vkqC-4jx2A:
undetectable		 5vkqB-4jx2A:
13.45
5vkqC-4jx2A:
13.45