SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jx6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		3 / 3 ALA A 869
VAL A 864
TRP A 861
 None
 0.84A 1av2C-4jx6A:
undetectable
1av2D-4jx6A:
undetectable		 1av2C-4jx6A:
5.06
1av2D-4jx6A:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		5 / 12 ARG A 566
ALA A1024
LEU A1007
LEU A1016
ILE A1034
 None
 1.14A 1bsxA-4jx6A:
undetectable		 1bsxA-4jx6A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		5 / 12 ARG A 566
ALA A1024
LEU A1007
LEU A1016
ILE A1034
 None
 1.14A 1bsxB-4jx6A:
undetectable		 1bsxB-4jx6A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		5 / 12 GLY A 622
ASN A 662
SER A 920
PHE A 654
VAL A 653
 None
None
None
KCX  A 718 ( 4.0A)
None
 1.13A 1ffyA-4jx6A:
undetectable		 1ffyA-4jx6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		4 / 7 HIS A 749
LEU A 554
SER A 553
ASP A 549
 ZN  A1102 (-3.4A)
None
None
ZN  A1102 (-2.8A)
 1.21A 1ismB-4jx6A:
1.1		 1ismB-4jx6A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		5 / 12 GLY A 622
ASN A 662
SER A 920
PHE A 654
VAL A 653
 None
None
None
KCX  A 718 ( 4.0A)
None
 1.18A 1qu3A-4jx6A:
undetectable		 1qu3A-4jx6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		3 / 3 ALA A 869
VAL A 864
TRP A 861
 None
 0.87A 1w5uC-4jx6A:
undetectable
1w5uD-4jx6A:
undetectable		 1w5uC-4jx6A:
5.06
1w5uD-4jx6A:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		5 / 11 THR A 588
ALA A 643
PRO A 600
ALA A 982
PHE A 651
 None
 0.97A 2admA-4jx6A:
undetectable		 2admA-4jx6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		5 / 11 THR A 588
ALA A 643
PRO A 600
ALA A 982
PHE A 651
 None
 0.98A 2admB-4jx6A:
undetectable		 2admB-4jx6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		3 / 3 LEU A 620
MET A 618
MET A 720
 None
None
KCX  A 718 ( 3.6A)
 0.91A 2vavF-4jx6A:
undetectable		 2vavF-4jx6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		4 / 8 TYR A 700
LEU A 697
LEU A 732
ALA A 728
 None
 0.97A 2wekA-4jx6A:
undetectable		 2wekA-4jx6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		4 / 7 GLY A 843
VAL A 591
LEU A 619
ARG A 621
 None
None
KCX  A 718 (-4.8A)
PYR  A1101 (-4.0A)
 0.91A 3elzA-4jx6A:
undetectable		 3elzA-4jx6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		4 / 4 PRO A 831
THR A 751
GLY A 550
THR A 546
 None
 0.98A 3ib1A-4jx6A:
undetectable		 3ib1A-4jx6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		4 / 4 GLY A 766
ASP A 768
GLY A 741
THR A 701
 None
MG  A1103 (-3.3A)
None
None
 1.09A 3k4vC-4jx6A:
undetectable		 3k4vC-4jx6A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		5 / 12 ALA A1024
LEU A1007
LEU A 480
LEU A1016
ILE A1034
 None
 1.11A 3uvvA-4jx6A:
undetectable		 3uvvA-4jx6A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		5 / 12 GLN A 783
ASP A 719
HIS A 747
SER A 553
LEU A 554
 ZN  A1102 ( 4.7A)
None
KCX  A 718 (-3.2A)
None
None
 1.34A 4kmuC-4jx6A:
undetectable		 4kmuC-4jx6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		5 / 12 GLN A 783
ASP A 719
HIS A 747
SER A 553
LEU A 554
 ZN  A1102 ( 4.7A)
None
KCX  A 718 (-3.2A)
None
None
 1.37A 4kmuH-4jx6A:
undetectable		 4kmuH-4jx6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		4 / 7 TYR A 700
ILE A 744
ILE A 715
ALA A 704
 None
 0.86A 4lv9B-4jx6A:
2.2		 4lv9B-4jx6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		4 / 8 THR A 751
MET A 840
GLY A 842
GLY A 843
 None
 0.83A 4qvvK-4jx6A:
undetectable
4qvvL-4jx6A:
undetectable		 4qvvK-4jx6A:
16.98
4qvvL-4jx6A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		4 / 8 THR A 751
MET A 840
GLY A 842
GLY A 843
 None
 0.83A 4qvvY-4jx6A:
undetectable
4qvvZ-4jx6A:
undetectable		 4qvvY-4jx6A:
16.98
4qvvZ-4jx6A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		5 / 12 THR A 882
VAL A 881
THR A 588
VAL A 591
GLU A 582
 PYR  A1101 (-4.4A)
None
None
None
None
 1.31A 4s0vA-4jx6A:
undetectable		 4s0vA-4jx6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		4 / 5 ASP A 655
VAL A 636
ASP A 633
GLY A 953
 None
 1.17A 4xp6A-4jx6A:
undetectable		 4xp6A-4jx6A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_A_FOLA201_0
(FOLATE ECF
TRANSPORTER)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		5 / 12 LEU A 985
MET A 618
ALA A 643
PHE A 589
THR A 588
 None
 1.21A 4z7fA-4jx6A:
undetectable		 4z7fA-4jx6A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		5 / 12 ASP A1043
SER A1040
THR A 478
ALA A 481
ASN A 486
 None
 1.49A 5dsgA-4jx6A:
undetectable		 5dsgA-4jx6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		5 / 11 PHE A 654
ASN A 624
ARG A 621
MET A 618
GLY A 586
 KCX  A 718 ( 4.0A)
None
PYR  A1101 (-4.0A)
None
PYR  A1101 ( 3.9A)
 1.49A 5yjsA-4jx6A:
undetectable		 5yjsA-4jx6A:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		4 / 7 ALA A 481
THR A 478
TYR A 479
VAL A 485
 None
 0.94A 6cduA-4jx6A:
undetectable
6cduE-4jx6A:
undetectable		 6cduA-4jx6A:
18.56
6cduE-4jx6A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		4 / 7 VAL A 485
ALA A 481
THR A 478
TYR A 479
 None
 0.91A 6cduH-4jx6A:
undetectable
6cduI-4jx6A:
undetectable		 6cduH-4jx6A:
18.56
6cduI-4jx6A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4jx6 PYRUVATE CARBOXYLASE
(Rhizobium
etli) 		4 / 7 HIS A 745
THR A 543
ARG A 737
ASP A 768
 None
None
None
MG  A1103 (-3.3A)
 1.32A 6mn4E-4jx6A:
undetectable		 6mn4E-4jx6A:
19.43