SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		4 / 5 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 AE6  A 301 ( 4.0A)
AE6  A 301 (-3.8A)
AE6  A 301 (-4.2A)
None
 1.29A 1kifA-4jx8A:
4.6		 1kifA-4jx8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		4 / 5 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 AE6  A 301 ( 4.0A)
AE6  A 301 (-3.8A)
AE6  A 301 (-4.2A)
None
 1.29A 1kifB-4jx8A:
4.6		 1kifB-4jx8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		4 / 5 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 AE6  A 301 ( 4.0A)
AE6  A 301 (-3.8A)
AE6  A 301 (-4.2A)
None
 1.29A 1kifC-4jx8A:
4.6		 1kifC-4jx8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		4 / 5 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 AE6  A 301 ( 4.0A)
AE6  A 301 (-3.8A)
AE6  A 301 (-4.2A)
None
 1.29A 1kifD-4jx8A:
4.6		 1kifD-4jx8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		4 / 5 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 AE6  A 301 ( 4.0A)
AE6  A 301 (-3.8A)
AE6  A 301 (-4.2A)
None
 1.29A 1kifE-4jx8A:
4.6		 1kifE-4jx8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		4 / 5 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 AE6  A 301 ( 4.0A)
AE6  A 301 (-3.8A)
AE6  A 301 (-4.2A)
None
 1.29A 1kifF-4jx8A:
4.6		 1kifF-4jx8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		4 / 5 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 AE6  A 301 ( 4.0A)
AE6  A 301 (-3.8A)
AE6  A 301 (-4.2A)
None
 1.29A 1kifG-4jx8A:
3.3		 1kifG-4jx8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		4 / 5 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 AE6  A 301 ( 4.0A)
AE6  A 301 (-3.8A)
AE6  A 301 (-4.2A)
None
 1.29A 1kifH-4jx8A:
4.6		 1kifH-4jx8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		5 / 12 GLY A  93
ILE A 115
ALA A  95
PHE A 124
SER A 123
 NAD  A 302 (-3.9A)
None
AE6  A 301 (-3.7A)
None
None
 1.10A 1ri4A-4jx8A:
5.7		 1ri4A-4jx8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		4 / 5 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 AE6  A 301 ( 4.0A)
AE6  A 301 (-3.8A)
AE6  A 301 (-4.2A)
None
 1.30A 1ve9A-4jx8A:
4.5		 1ve9A-4jx8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		4 / 5 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 AE6  A 301 ( 4.0A)
AE6  A 301 (-3.8A)
AE6  A 301 (-4.2A)
None
 1.33A 2du8G-4jx8A:
4.5		 2du8G-4jx8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		4 / 5 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 AE6  A 301 ( 4.0A)
AE6  A 301 (-3.8A)
AE6  A 301 (-4.2A)
None
 1.33A 2du8J-4jx8A:
4.4		 2du8J-4jx8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		4 / 4 ILE A  20
GLN A  26
ILE A 187
LEU A  55
 NAD  A 302 (-2.9A)
None
None
None
 1.18A 3dzyD-4jx8A:
undetectable		 3dzyD-4jx8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		5 / 9 LEU A 142
VAL A  11
ILE A  20
ALA A  21
ALA A  27
 None
None
NAD  A 302 (-2.9A)
None
None
 1.30A 3mdtA-4jx8A:
undetectable		 3mdtA-4jx8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		4 / 8 ILE A  59
LEU A  78
LYS A   7
PHE A  85
 None
 1.04A 3selX-4jx8A:
undetectable		 3selX-4jx8A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		5 / 9 ILE A  59
LEU A  78
LYS A   7
PHE A  85
GLY A  87
 None
 1.27A 3sj4X-4jx8A:
undetectable		 3sj4X-4jx8A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		5 / 12 LEU A 144
THR A  12
ALA A  21
ILE A 222
ILE A  24
 NAD  A 302 (-3.9A)
None
None
None
None
 0.95A 3ut5B-4jx8A:
6.7		 3ut5B-4jx8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		5 / 12 LEU A 144
THR A  12
ALA A  21
ILE A 222
ILE A  24
 NAD  A 302 (-3.9A)
None
None
None
None
 0.88A 5itzB-4jx8A:
7.0		 5itzB-4jx8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		5 / 12 LEU A 144
THR A  12
ALA A  21
ILE A 222
ILE A  24
 NAD  A 302 (-3.9A)
None
None
None
None
 0.87A 5xiwB-4jx8A:
6.6		 5xiwB-4jx8A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		5 / 12 ALA A 230
GLY A 226
GLY A  23
LEU A 236
PHE A   3
 None
 1.17A 5ybbA-4jx8A:
4.5		 5ybbA-4jx8A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI
(Escherichia
coli) 		5 / 12 ALA A 230
ALA A 229
ILE A 222
ARG A  30
LEU A 144
 None
None
None
None
NAD  A 302 (-3.9A)
 0.97A 6a5zD-4jx8A:
undetectable		 6a5zD-4jx8A:
15.77