SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 SER A  52
GLY A  50
LEU A  86
TYR A  89
 None
 0.93A 1fduD-4jxbA:
undetectable		 1fduD-4jxbA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.19A 1fk9A-4jxbA:
undetectable		 1fk9A-4jxbA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.12A 1fkpA-4jxbA:
undetectable		 1fkpA-4jxbA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.15A 1jkhA-4jxbA:
undetectable
1jkhB-4jxbA:
undetectable		 1jkhA-4jxbA:
14.51
1jkhB-4jxbA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.22A 1lwcA-4jxbA:
undetectable		 1lwcA-4jxbA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.29A 1lwfA-4jxbA:
undetectable		 1lwfA-4jxbA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  96
GLY A 109
LEU A 167
TYR A  91
 None
 0.90A 1s1xA-4jxbA:
undetectable		 1s1xA-4jxbA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.17A 1vrtA-4jxbA:
undetectable		 1vrtA-4jxbA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 166
LEU A 167
LEU A 122
GLY A  95
LEU A  98
 None
 0.86A 2aylA-4jxbA:
undetectable		 2aylA-4jxbA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.19A 2hndA-4jxbA:
undetectable		 2hndA-4jxbA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.21A 2hnyA-4jxbA:
undetectable		 2hnyA-4jxbA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  73
GLY A  80
GLY A  62
LEU A  86
VAL A  56
 None
 1.14A 2wa2A-4jxbA:
undetectable		 2wa2A-4jxbA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.24A 3lp1A-4jxbA:
undetectable		 3lp1A-4jxbA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 166
LEU A 167
LEU A 122
GLY A  95
LEU A  98
 None
 0.82A 3nt1A-4jxbA:
undetectable		 3nt1A-4jxbA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 166
LEU A 167
LEU A 122
GLY A  95
LEU A  98
 None
 0.82A 3nt1B-4jxbA:
undetectable		 3nt1B-4jxbA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  85
GLY A  63
SER A  59
ILE A  65
SER A  66
 None
 0.88A 4qdjA-4jxbA:
undetectable		 4qdjA-4jxbA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 166
LEU A 167
LEU A 122
GLY A  95
LEU A  98
 None
 0.91A 5jvzA-4jxbA:
undetectable		 5jvzA-4jxbA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 166
LEU A 167
LEU A 122
GLY A  95
LEU A  98
 None
 0.92A 5jvzB-4jxbA:
undetectable		 5jvzB-4jxbA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.23A 6bsiA-4jxbA:
undetectable		 6bsiA-4jxbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4jxb INVASION-ASSOCIATED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.15A 6bsjA-4jxbA:
undetectable		 6bsjA-4jxbA:
22.02