SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jxc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 8 GLU A 146
ARG A 142
LEU A 190
GLU A 189
 None
 0.84A 1cmaA-4jxcA:
undetectable
1cmaB-4jxcA:
undetectable		 1cmaA-4jxcA:
13.18
1cmaB-4jxcA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 8 ARG A 180
LEU A 184
VAL A 225
GLY A 226
 SAM  A 402 (-3.3A)
CSO  A 183 ( 4.4A)
None
None
 0.92A 1hrkA-4jxcA:
undetectable		 1hrkA-4jxcA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 8 ARG A 180
LEU A 184
VAL A 225
GLY A 226
 SAM  A 402 (-3.3A)
CSO  A 183 ( 4.4A)
None
None
 0.87A 1hrkB-4jxcA:
undetectable		 1hrkB-4jxcA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		5 / 12 PHE A 216
LEU A 215
LEU A 259
LEU A 184
PHE A 222
 None
None
None
CSO  A 183 ( 4.4A)
None
 1.24A 1og5A-4jxcA:
undetectable		 1og5A-4jxcA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		3 / 3 CYH A 311
ARG A 300
CYH A 319
 FES  A 409 ( 2.2A)
None
H2S  A 410 ( 2.0A)
 1.31A 1p9gA-4jxcA:
undetectable		 1p9gA-4jxcA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 7 GLY A 226
MET A 271
ILE A 265
VAL A 225
 None
 1.05A 1rxcC-4jxcA:
undetectable		 1rxcC-4jxcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 7 GLY A 226
MET A 271
ILE A 265
VAL A 225
 None
 1.08A 1rxcD-4jxcA:
undetectable		 1rxcD-4jxcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 7 GLY A 226
MET A 271
ILE A 265
VAL A 225
 None
 1.07A 1rxcF-4jxcA:
undetectable		 1rxcF-4jxcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 7 GLY A 226
MET A 271
ILE A 265
VAL A 225
 None
 1.03A 1rxcL-4jxcA:
undetectable		 1rxcL-4jxcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		5 / 10 THR A 282
GLY A 272
THR A 269
ALA A 270
VAL A 253
 None
None
CL  A 414 (-4.7A)
CL  A 414 (-3.8A)
None
 1.26A 2coiA-4jxcA:
undetectable
2coiB-4jxcA:
undetectable		 2coiA-4jxcA:
23.63
2coiB-4jxcA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		5 / 10 VAL A 253
THR A 282
GLY A 272
THR A 269
ALA A 270
 None
None
None
CL  A 414 (-4.7A)
CL  A 414 (-3.8A)
 1.23A 2coiA-4jxcA:
undetectable
2coiB-4jxcA:
undetectable		 2coiA-4jxcA:
23.63
2coiB-4jxcA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		5 / 11 THR A 282
GLY A 272
THR A 269
ALA A 270
VAL A 253
 None
None
CL  A 414 (-4.7A)
CL  A 414 (-3.8A)
None
 1.24A 2cojA-4jxcA:
undetectable
2cojB-4jxcA:
undetectable		 2cojA-4jxcA:
23.63
2cojB-4jxcA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		5 / 9 VAL A 253
THR A 282
GLY A 272
THR A 269
ALA A 270
 None
None
None
CL  A 414 (-4.7A)
CL  A 414 (-3.8A)
 1.17A 2cojA-4jxcA:
undetectable
2cojB-4jxcA:
undetectable		 2cojA-4jxcA:
23.63
2cojB-4jxcA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		5 / 12 SER A 136
GLY A 226
ALA A 196
GLY A 195
VAL A 253
 SAM  A 402 (-3.9A)
None
None
None
None
 0.97A 2nyuA-4jxcA:
undetectable		 2nyuA-4jxcA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		5 / 12 SER A 136
GLY A 226
ALA A 196
GLY A 195
VAL A 253
 SAM  A 402 (-3.9A)
None
None
None
None
 0.96A 2nyuB-4jxcA:
undetectable		 2nyuB-4jxcA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 6 LYS A  21
LEU A  20
LYS A 251
LEU A 255
 None
 0.91A 3h5gA-4jxcA:
undetectable
3h5gC-4jxcA:
undetectable		 3h5gA-4jxcA:
6.47
3h5gC-4jxcA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 4 LEU A 238
PRO A 237
LEU A  68
ARG A 172
 None
 1.33A 3hcoB-4jxcA:
undetectable		 3hcoB-4jxcA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		12 / 12 TYR A  69
CYH A  70
GLN A 107
SER A 136
GLY A 138
ARG A 159
ARG A 180
MET A 199
ILE A 231
TYR A 303
LEU A 305
TYR A 306
 SAM  A 402 (-4.6A)
SF4  A 401 (-2.2A)
SAM  A 402 ( 3.8A)
SAM  A 402 (-3.9A)
SAM  A 402 (-3.8A)
SAM  A 402 ( 4.2A)
SAM  A 402 (-3.3A)
SAM  A 402 (-3.5A)
SAM  A 402 (-4.4A)
None
SAM  A 402 (-3.3A)
SAM  A 402 ( 4.6A)
 0.23A 3iizA-4jxcA:
64.8		 3iizA-4jxcA:
99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		5 / 10 ALA A 151
LEU A 135
VAL A 133
ILE A  89
ILE A 126
 None
 1.13A 3jw3A-4jxcA:
undetectable		 3jw3A-4jxcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 6 GLY A 226
MET A 271
ILE A 265
VAL A 225
 None
 1.05A 3kvvA-4jxcA:
undetectable		 3kvvA-4jxcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 6 GLY A 226
MET A 271
ILE A 265
VAL A 225
 None
 1.04A 3kvvB-4jxcA:
undetectable		 3kvvB-4jxcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 6 GLY A 226
MET A 271
ILE A 265
VAL A 225
 None
 1.03A 3kvvC-4jxcA:
undetectable		 3kvvC-4jxcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 6 GLY A 226
MET A 271
ILE A 265
VAL A 225
 None
 1.02A 3kvvD-4jxcA:
undetectable		 3kvvD-4jxcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 6 GLY A 226
MET A 271
ILE A 265
VAL A 225
 None
 1.02A 3kvvE-4jxcA:
undetectable		 3kvvE-4jxcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 6 GLY A 226
MET A 271
ILE A 265
VAL A 225
 None
 1.06A 3kvvF-4jxcA:
undetectable		 3kvvF-4jxcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		5 / 11 LEU A 250
THR A 249
VAL A 253
LEU A 283
THR A 268
 None
None
None
None
CL  A 414 ( 4.4A)
 1.39A 3tbgA-4jxcA:
undetectable		 3tbgA-4jxcA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 7 GLY A 226
MET A 271
ILE A 265
VAL A 225
 None
 1.01A 4e1vB-4jxcA:
undetectable		 4e1vB-4jxcA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 6 GLY A 226
MET A 271
ILE A 265
VAL A 225
 None
 1.05A 4e1vF-4jxcA:
undetectable		 4e1vF-4jxcA:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		12 / 12 TYR A  69
CYH A  70
GLN A 107
SER A 136
GLY A 138
ARG A 159
ARG A 180
MET A 199
ILE A 231
TYR A 303
LEU A 305
TYR A 306
 SAM  A 402 (-4.6A)
SF4  A 401 (-2.2A)
SAM  A 402 ( 3.8A)
SAM  A 402 (-3.9A)
SAM  A 402 (-3.8A)
SAM  A 402 ( 4.2A)
SAM  A 402 (-3.3A)
SAM  A 402 (-3.5A)
SAM  A 402 (-4.4A)
None
SAM  A 402 (-3.3A)
SAM  A 402 ( 4.6A)
 0.20A 4jxcA-4jxcA:
66.2		 4jxcA-4jxcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 6 ARG A  73
GLY A  71
ASP A  75
ARG A  81
 None
 0.77A 4lajA-4jxcA:
undetectable
4lajB-4jxcA:
undetectable		 4lajA-4jxcA:
19.70
4lajB-4jxcA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		4 / 7 GLU A 161
GLY A 228
GLY A 201
TYR A  69
 SAM  A 402 (-2.8A)
None
None
SAM  A 402 (-4.6A)
 0.94A 5e26A-4jxcA:
undetectable
5e26B-4jxcA:
undetectable		 5e26A-4jxcA:
23.23
5e26B-4jxcA:
23.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		12 / 12 TYR A  69
CYH A  70
GLN A 107
SER A 136
GLY A 138
LEU A 158
ARG A 159
ARG A 180
MET A 199
ILE A 231
TYR A 303
TYR A 306
 SAM  A 402 (-4.6A)
SF4  A 401 (-2.2A)
SAM  A 402 ( 3.8A)
SAM  A 402 (-3.9A)
SAM  A 402 (-3.8A)
None
SAM  A 402 ( 4.2A)
SAM  A 402 (-3.3A)
SAM  A 402 (-3.5A)
SAM  A 402 (-4.4A)
None
SAM  A 402 ( 4.6A)
 0.15A 5fepA-4jxcA:
63.7		 5fepA-4jxcA:
96.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		5 / 12 CYH A  67
SER A 136
GLY A 138
ARG A 159
MET A 199
 SF4  A 401 (-2.3A)
SAM  A 402 (-3.9A)
SAM  A 402 (-3.8A)
SAM  A 402 ( 4.2A)
SAM  A 402 (-3.5A)
 1.46A 5fesA-4jxcA:
64.2		 5fesA-4jxcA:
96.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		12 / 12 TYR A  69
CYH A  70
GLN A 107
SER A 136
GLY A 138
LEU A 158
ARG A 159
ARG A 180
MET A 199
ILE A 231
TYR A 303
TYR A 306
 SAM  A 402 (-4.6A)
SF4  A 401 (-2.2A)
SAM  A 402 ( 3.8A)
SAM  A 402 (-3.9A)
SAM  A 402 (-3.8A)
None
SAM  A 402 ( 4.2A)
SAM  A 402 (-3.3A)
SAM  A 402 (-3.5A)
SAM  A 402 (-4.4A)
None
SAM  A 402 ( 4.6A)
 0.11A 5fesA-4jxcA:
64.2		 5fesA-4jxcA:
96.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 4jxc FEFE-HYDROGENASE
MATURASE
(Thermotoga
maritima) 		5 / 12 LEU A  35
LEU A  38
ALA A  39
LEU A 214
LEU A 250
 None
 0.86A 5toaA-4jxcA:
undetectable		 5toaA-4jxcA:
21.82