SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 12 LEU A  18
VAL A  26
ALA A  39
GLY A  95
LEU A 143
ALA A 153
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
631  A 301 (-3.4A)
 0.59A 1iepA-4jxfA:
20.5		 1iepA-4jxfA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		5 / 12 LEU A 241
VAL A 259
LEU A 197
MET A 200
LEU A 142
 None
 1.25A 1mx1E-4jxfA:
undetectable		 1mx1E-4jxfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		5 / 12 VAL A  26
ALA A  39
LEU A  73
CYH A  92
LEU A 127
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
None
631  A 301 (-4.5A)
None
 0.33A 1uwjA-4jxfA:
19.1		 1uwjA-4jxfA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		5 / 12 VAL A  26
ALA A  39
LEU A  73
CYH A  92
LEU A 127
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
None
631  A 301 (-4.5A)
None
 0.34A 1uwjB-4jxfA:
19.1		 1uwjB-4jxfA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 9 LEU A  18
VAL A  26
ALA A  39
MET A  91
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-3.7A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.56A 1xbbA-4jxfA:
18.2		 1xbbA-4jxfA:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		5 / 9 LEU A  18
VAL A  26
LYS A  41
LEU A  75
LEU A  87
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-2.7A)
None
None
 0.67A 1xkkA-4jxfA:
18.4		 1xkkA-4jxfA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 12 VAL A  26
ALA A  39
LEU A  73
LEU A  89
GLY A  95
ALA A 153
ASP A 154
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
None
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-3.4A)
EDO  A 302 (-3.7A)
 0.76A 2wgjA-4jxfA:
13.1		 2wgjA-4jxfA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 9 LEU A  18
VAL A  26
ALA A  39
LEU A  89
GLY A  95
LEU A 143
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
EDO  A 302 (-3.7A)
 0.78A 2xp2A-4jxfA:
19.0		 2xp2A-4jxfA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 12 VAL A  26
ALA A  39
LYS A  41
LEU A  87
GLY A  95
LEU A 143
PHE A 155
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
None
 0.74A 3bbtD-4jxfA:
19.1		 3bbtD-4jxfA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		4 / 6 LEU A  18
VAL A  26
LYS A  41
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-2.7A)
EDO  A 302 (-3.7A)
 0.66A 3cs9D-4jxfA:
19.8		 3cs9D-4jxfA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		4 / 6 LEU A  18
VAL A  26
LYS A  41
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-2.7A)
631  A 301 (-4.0A)
 0.50A 3cs9D-4jxfA:
19.8		 3cs9D-4jxfA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 11 LEU A  18
VAL A  26
ALA A  39
CYH A  92
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.42A 3g0eA-4jxfA:
17.6		 3g0eA-4jxfA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 11 LEU A  18
VAL A  26
ALA A  39
CYH A  92
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.47A 3g0fA-4jxfA:
18.1		 3g0fA-4jxfA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 10 LEU A  18
VAL A  26
ALA A  39
CYH A  92
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.42A 3g0fB-4jxfA:
18.4		 3g0fB-4jxfA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 12 LEU A  18
VAL A  26
ALA A  39
GLY A  95
LEU A 143
ALA A 153
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
631  A 301 (-3.4A)
 0.54A 3ms9B-4jxfA:
20.3		 3ms9B-4jxfA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 12 LEU A  18
VAL A  26
ALA A  39
GLY A  95
LEU A 143
ALA A 153
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
631  A 301 (-3.4A)
 0.55A 3mssB-4jxfA:
20.5		 3mssB-4jxfA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 12 VAL A  26
ALA A  39
LYS A  41
LEU A  73
CYH A  92
PHE A 155
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
631  A 301 (-4.5A)
None
 0.86A 3og7A-4jxfA:
19.5		 3og7A-4jxfA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 12 LEU A  18
VAL A  26
ALA A  39
LYS A  41
LEU A  87
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.75A 3ug2A-4jxfA:
17.9		 3ug2A-4jxfA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 12 LEU A  18
VAL A  26
ALA A  39
CYH A  92
GLY A  95
PHE A 155
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
None
 0.29A 3wzdA-4jxfA:
19.8		 3wzdA-4jxfA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		5 / 12 ALA A  39
LEU A  73
LEU A  89
GLY A  95
LEU A 143
 631  A 301 (-3.3A)
None
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.40A 3zbfA-4jxfA:
19.9		 3zbfA-4jxfA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 12 LEU A  18
VAL A  26
ALA A  39
LYS A  41
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.53A 4agcA-4jxfA:
8.5		 4agcA-4jxfA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		5 / 11 LEU A  18
ALA A  39
CYH A  92
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-3.3A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.38A 4agdA-4jxfA:
18.1		 4agdA-4jxfA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		8 / 9 LEU A  18
VAL A  26
ALA A  39
LEU A  89
GLY A  95
LEU A 143
ALA A 153
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
631  A 301 (-3.4A)
EDO  A 302 (-3.7A)
 0.75A 4anqA-4jxfA:
18.8		 4anqA-4jxfA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 9 LEU A  18
VAL A  26
ALA A  39
GLY A  95
LEU A 143
ALA A 153
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
631  A 301 (-3.4A)
EDO  A 302 (-3.7A)
 0.67A 4ansA-4jxfA:
18.8		 4ansA-4jxfA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		5 / 11 LEU A 241
LEU A 245
ILE A 242
LEU A 205
ILE A 121
 None
 1.11A 4dm8A-4jxfA:
undetectable		 4dm8A-4jxfA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		4 / 6 GLU A  96
ASN A 141
GLU A  60
HIS A  64
 None
EDO  A 302 ( 4.3A)
None
None
 1.02A 4ejwB-4jxfA:
undetectable		 4ejwB-4jxfA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 12 LEU A  18
VAL A  26
ALA A  39
LEU A  89
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.58A 4mkcA-4jxfA:
18.9		 4mkcA-4jxfA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		4 / 6 VAL A  26
ALA A  39
LEU A  73
LEU A 143
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
None
631  A 301 (-4.0A)
 0.41A 4o0uA-4jxfA:
10.8		 4o0uA-4jxfA:
34.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		4 / 6 VAL A  26
ALA A  39
LYS A  41
LEU A  73
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
 0.69A 4o0uA-4jxfA:
10.8		 4o0uA-4jxfA:
34.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		5 / 12 VAL A  26
ALA A  39
LEU A  73
CYH A  92
PHE A 155
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
None
631  A 301 (-4.5A)
None
 0.71A 4rzvB-4jxfA:
19.0		 4rzvB-4jxfA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		5 / 12 VAL A  26
ALA A  39
LYS A  41
LEU A  73
CYH A  92
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
631  A 301 (-4.5A)
 0.75A 4rzvB-4jxfA:
19.0		 4rzvB-4jxfA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		4 / 6 LEU A  18
VAL A  26
ILE A  72
ILE A 152
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
None
None
 0.43A 4tyjA-4jxfA:
19.3		 4tyjA-4jxfA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		4 / 6 VAL A  26
LYS A  41
ILE A  72
ILE A 152
 631  A 301 (-4.6A)
631  A 301 (-2.7A)
None
None
 0.58A 4tyjA-4jxfA:
19.3		 4tyjA-4jxfA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 9 LEU A  18
VAL A  26
ALA A  39
GLY A  95
LEU A 143
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
EDO  A 302 (-3.7A)
 0.59A 4u5jB-4jxfA:
11.2		 4u5jB-4jxfA:
29.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		5 / 12 LEU A  18
ALA A  39
LEU A 127
LEU A 143
ALA A 153
 631  A 301 (-3.4A)
631  A 301 (-3.3A)
None
631  A 301 (-4.0A)
631  A 301 (-3.4A)
 0.49A 4uxqA-4jxfA:
19.0		 4uxqA-4jxfA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		4 / 5 LEU A 144
GLU A  96
LEU A 204
HIS A 115
 None
 1.33A 4xi3B-4jxfA:
undetectable		 4xi3B-4jxfA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 9 LEU A  18
VAL A  26
ALA A  39
LEU A  89
GLY A  95
LEU A 143
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
EDO  A 302 (-3.7A)
 0.83A 5aaaA-4jxfA:
19.0		 5aaaA-4jxfA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 10 LEU A  18
VAL A  26
ALA A  39
LYS A  41
LEU A  89
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.65A 5aabA-4jxfA:
18.9		 5aabA-4jxfA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 10 LEU A  18
VAL A  26
ALA A  39
LEU A  89
GLY A  95
LEU A 143
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
EDO  A 302 (-3.7A)
 0.76A 5aacA-4jxfA:
19.1		 5aacA-4jxfA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 10 LEU A  18
VAL A  26
ALA A  39
LYS A  41
LEU A  89
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 ( 4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.65A 5aacA-4jxfA:
19.1		 5aacA-4jxfA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 12 LEU A  18
ALA A  39
LYS A  41
CYH A  92
GLY A  95
LEU A 143
ALA A 153
 631  A 301 (-3.4A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
631  A 301 (-3.4A)
 0.70A 5ajqA-4jxfA:
21.4		 5ajqA-4jxfA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 12 LEU A  18
GLY A  19
ALA A  39
CYH A  92
GLY A  95
LEU A 143
ALA A 153
 631  A 301 (-3.4A)
631  A 301 (-3.6A)
631  A 301 (-3.3A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
631  A 301 (-3.4A)
 0.72A 5ajqA-4jxfA:
21.4		 5ajqA-4jxfA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 12 LEU A  18
GLY A  19
CYH A  92
GLY A  95
LEU A 143
ALA A 153
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-3.6A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
631  A 301 (-3.4A)
EDO  A 302 (-3.7A)
 0.92A 5ajqA-4jxfA:
21.4		 5ajqA-4jxfA:
28.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 12 LEU A  18
VAL A  26
ALA A  39
LEU A  73
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
None
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.81A 5h2uA-4jxfA:
13.4		 5h2uA-4jxfA:
31.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		4 / 6 LEU A 256
SER A 257
ASP A 261
HIS A 118
 None
 1.09A 5om3A-4jxfA:
undetectable
5om3B-4jxfA:
undetectable		 5om3A-4jxfA:
15.30
5om3B-4jxfA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		6 / 12 LEU A  18
VAL A  26
ALA A  39
LYS A  41
LEU A  87
CYH A  92
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
631  A 301 (-4.5A)
 0.68A 5vcyA-4jxfA:
18.4		 5vcyA-4jxfA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 12 ARG A  28
LEU A  18
VAL A  26
LYS A  41
CYH A  92
GLY A  95
LEU A 143
 631  A 301 ( 4.7A)
631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-2.7A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 1.03A 5y7zA-4jxfA:
18.6		 5y7zA-4jxfA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 12 ARG A  28
LEU A  18
VAL A  26
LYS A  41
CYH A  92
GLY A  95
LEU A 143
 631  A 301 ( 4.7A)
631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-2.7A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 1.03A 5y7zA-4jxfA:
18.6		 5y7zA-4jxfA:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 12 LEU A  18
VAL A  26
ALA A  39
LYS A  41
CYH A  92
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.72A 5y7zA-4jxfA:
18.6		 5y7zA-4jxfA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 12 LEU A  18
VAL A  26
ALA A  39
LYS A  41
CYH A  92
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.72A 5y7zA-4jxfA:
18.6		 5y7zA-4jxfA:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 12 LEU A  18
ALA A  39
LYS A  41
LEU A  87
CYH A  92
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.77A 5y7zB-4jxfA:
10.9		 5y7zB-4jxfA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 12 LEU A  18
VAL A  26
ALA A  39
LYS A  41
CYH A  92
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.53A 5y80A-4jxfA:
18.8		 5y80A-4jxfA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens) 		7 / 12 LEU A  18
GLY A  19
VAL A  26
ALA A  39
LYS A  41
GLY A  95
ALA A 153
 631  A 301 (-3.4A)
631  A 301 (-3.6A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 ( 3.7A)
631  A 301 (-3.4A)
 0.80A 5zv2B-4jxfA:
20.2		 5zv2B-4jxfA:
14.86