SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 11 GLY A  52
THR A  53
GLU A  72
LEU A  91
ARG A  58
None
None
None
None
IOD  A 302 ( 4.9A)
1.42A 1i7qA-4jxjA:
undetectable
1i7qA-4jxjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
4 / 5 LEU A 117
VAL A 126
ALA A 171
CYH A 167
None
1.12A 1mz9D-4jxjA:
undetectable
1mz9D-4jxjA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
7 / 12 GLU A  48
GLY A  50
GLY A  52
ASP A  74
ASN A 116
PRO A 118
ILE A 121
None
0.79A 1qaoA-4jxjA:
22.5
1qaoA-4jxjA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
7 / 12 GLU A  48
GLY A  50
GLY A  52
ASP A  74
ILE A  71
ASN A 116
PRO A 118
None
1.15A 1qaoA-4jxjA:
22.5
1qaoA-4jxjA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
7 / 12 PHE A  24
GLU A  48
GLY A  50
GLY A  52
ASN A 116
PRO A 118
ILE A 121
None
0.76A 1qaoA-4jxjA:
22.5
1qaoA-4jxjA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
7 / 12 PHE A  24
GLU A  48
GLY A  50
GLY A  52
ILE A  71
ASN A 116
PRO A 118
None
1.24A 1qaoA-4jxjA:
22.5
1qaoA-4jxjA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 GLY A  52
PRO A 118
ILE A 121
MET A 142
SER A 192
None
1.15A 1zq9A-4jxjA:
26.5
1zq9A-4jxjA:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
3 / 3 GLY A  50
GLU A  72
ASN A 116
None
0.57A 1zq9A-4jxjA:
26.0
1zq9A-4jxjA:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 GLY A  50
GLY A  52
ASN A 116
ILE A 121
PHE A 184
None
0.54A 1zq9B-4jxjA:
25.7
1zq9B-4jxjA:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
3 / 3 SER A 266
ASP A 260
CYH A 251
None
0.99A 2br4E-4jxjA:
9.5
2br4E-4jxjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
4 / 6 LEU A 264
TYR A 261
ILE A 247
ILE A 227
None
0.93A 2q8hA-4jxjA:
undetectable
2q8hA-4jxjA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 11 LEU A 117
ILE A  49
GLY A  50
GLY A  52
LEU A 141
None
0.91A 2qmmA-4jxjA:
undetectable
2qmmB-4jxjA:
undetectable
2qmmA-4jxjA:
23.11
2qmmB-4jxjA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 ILE A 111
PHE A 220
TYR A 160
ALA A 219
LEU A 169
None
IOD  A 305 ( 4.8A)
None
None
None
1.30A 2x2nD-4jxjA:
undetectable
2x2nD-4jxjA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 GLY A  52
THR A  53
GLY A  55
ASN A 116
PRO A 118
None
0.74A 2y7hB-4jxjA:
11.3
2y7hB-4jxjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 GLY A  52
THR A  53
GLY A  55
ASN A 116
PRO A 118
None
0.75A 2y7hC-4jxjA:
8.8
2y7hC-4jxjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 GLY A  50
GLY A  52
LEU A  56
ASN A 116
PRO A 118
None
0.80A 2zulA-4jxjA:
10.9
2zulA-4jxjA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 GLY A  50
GLY A  52
GLU A  72
ALA A  98
LEU A  56
None
1.13A 3ckkA-4jxjA:
8.5
3ckkA-4jxjA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 GLY A  50
GLY A  52
LEU A  56
ASN A 116
PRO A 118
None
0.77A 3dmhA-4jxjA:
10.7
3dmhA-4jxjA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 11 GLU A  48
GLY A  50
GLY A  52
GLU A  72
ALA A  98
None
0.70A 3dxyA-4jxjA:
10.5
3dxyA-4jxjA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 11 GLU A  48
GLY A  50
GLY A  52
ILE A  71
GLU A  72
None
0.59A 3dxyA-4jxjA:
10.5
3dxyA-4jxjA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 ASN A  45
ILE A  49
GLY A  50
ASN A  92
THR A  73
None
0.81A 3eeyC-4jxjA:
12.2
3eeyC-4jxjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 ASN A  45
ILE A  49
GLY A  50
ASN A  92
THR A  73
None
0.80A 3eeyE-4jxjA:
12.2
3eeyE-4jxjA:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
8 / 12 GLY A  50
GLY A  52
GLU A  72
ASP A  74
ALA A  98
PRO A 118
HIS A 120
ILE A 121
None
0.78A 3fuuA-4jxjA:
28.3
3fuuA-4jxjA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
7 / 11 GLY A  50
GLU A  72
ASP A  74
ALA A  98
ASN A 116
PRO A 118
ILE A 121
None
0.70A 3grvA-4jxjA:
27.6
3grvA-4jxjA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
7 / 11 GLY A  50
GLY A  52
GLU A  72
ALA A  98
ASN A 116
PRO A 118
ILE A 121
None
0.71A 3grvA-4jxjA:
27.6
3grvA-4jxjA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
7 / 12 GLU A  48
GLY A  50
GLU A  72
ASP A  74
ALA A  98
ASN A 116
PRO A 118
None
0.74A 3gryA-4jxjA:
27.4
3gryA-4jxjA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
7 / 12 GLU A  48
GLY A  50
GLY A  52
GLU A  72
ALA A  98
ASN A 116
PRO A 118
None
0.71A 3gryA-4jxjA:
27.4
3gryA-4jxjA:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 VAL A 148
CYH A 152
LEU A 130
VAL A 195
LEU A 141
None
IOD  A 307 ( 4.6A)
None
None
None
1.06A 4po0A-4jxjA:
undetectable
4po0A-4jxjA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
4 / 6 ILE A  84
GLY A  54
ILE A 114
VAL A  70
IOD  A 302 (-3.9A)
None
None
None
0.74A 4r21A-4jxjA:
undetectable
4r21A-4jxjA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 GLY A  52
GLY A  54
GLY A  55
LEU A  56
GLU A  72
None
0.86A 5c0oF-4jxjA:
13.7
5c0oF-4jxjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 9 ILE A  93
LEU A  91
GLU A  48
THR A  57
GLY A  52
None
1.14A 5ifuB-4jxjA:
2.1
5ifuB-4jxjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 10 GLY A  50
GLY A  52
GLU A  72
ASP A  74
CYH A  77
None
1.06A 6exiA-4jxjA:
6.3
6exiA-4jxjA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 10 GLY A  50
GLY A  52
GLU A  72
ASP A  74
CYH A  77
None
1.02A 6exiB-4jxjA:
4.4
6exiB-4jxjA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 GLY A  50
GLY A  52
GLU A  72
ASP A  74
CYH A  77
None
1.06A 6exiC-4jxjA:
4.4
6exiD-4jxjA:
4.3
6exiC-4jxjA:
19.76
6exiD-4jxjA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
5 / 12 GLY A  50
GLY A  52
GLU A  72
ASP A  74
CYH A  77
None
1.07A 6exiC-4jxjA:
4.9
6exiD-4jxjA:
4.4
6exiC-4jxjA:
19.76
6exiD-4jxjA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
6 / 12 GLU A  48
ILE A  49
GLY A  50
GLY A  52
ASP A  74
PRO A 118
None
0.53A 6iftA-4jxjA:
27.8
6iftA-4jxjA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii)
6 / 12 PHE A  24
GLU A  48
ILE A  49
GLY A  50
GLY A  52
PRO A 118
None
0.47A 6iftA-4jxjA:
27.8
6iftA-4jxjA:
33.00