SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jxk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 12 ILE A 269
LEU A 282
VAL A 161
ALA A 165
ILE A 126
 None
 1.02A 1epbA-4jxkA:
undetectable		 1epbA-4jxkA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		4 / 6 LEU A 286
ALA A 133
HIS A  89
ASP A  67
 None
 1.30A 2dpzA-4jxkA:
undetectable		 2dpzA-4jxkA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 9 PHE A 259
GLY A 263
ILE A 235
ALA A 240
VAL A 241
 None
 1.33A 2drdA-4jxkA:
undetectable		 2drdA-4jxkA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		4 / 6 THR A 122
ARG A 121
THR A 299
THR A 163
 None
 0.93A 2okcB-4jxkA:
5.7		 2okcB-4jxkA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		3 / 3 ARG A 322
GLY A 321
SER A 180
 EDO  A 402 (-4.0A)
None
None
 0.64A 2xctB-4jxkA:
undetectable		 2xctB-4jxkA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 12 ILE A  66
ASP A  46
ASP A  67
LEU A 286
ARG A 279
 None
 1.37A 2ya7C-4jxkA:
undetectable		 2ya7C-4jxkA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 9 VAL A 166
GLY A 160
GLY A 159
LEU A 168
ALA A 133
 None
EDO  A 402 (-3.6A)
None
None
None
 0.97A 2z0yA-4jxkA:
2.9		 2z0yA-4jxkA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		4 / 8 GLY A 130
VAL A 164
LEU A 295
PRO A 292
 None
 0.98A 3bgdB-4jxkA:
5.5		 3bgdB-4jxkA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 12 PHE A 174
VAL A 137
ALA A 139
ALA A 218
GLU A 146
 None
 1.24A 3dl9B-4jxkA:
undetectable		 3dl9B-4jxkA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 8 PRO A  61
ALA A   9
PRO A  64
ILE A  62
GLU A  59
 None
 1.36A 3dtuC-4jxkA:
undetectable
3dtuD-4jxkA:
undetectable		 3dtuC-4jxkA:
21.01
3dtuD-4jxkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 12 GLY A 162
LEU A 153
SER A 180
SER A 244
GLY A 245
 None
 1.09A 3g2oA-4jxkA:
6.0		 3g2oA-4jxkA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		4 / 8 THR A 190
LEU A 192
ALA A 157
ALA A 178
 None
 1.01A 3ns1L-4jxkA:
undetectable		 3ns1L-4jxkA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 12 GLY A 162
GLY A 159
VAL A 164
THR A 163
VAL A 176
 None
 1.03A 4f84A-4jxkA:
7.1		 4f84A-4jxkA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 11 GLY A 225
GLY A 224
ALA A 229
LEU A 228
HIS A 230
 None
 1.14A 4l8fB-4jxkA:
2.3		 4l8fB-4jxkA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 11 GLY A 225
GLY A 224
ALA A 229
LEU A 228
HIS A 230
 None
 1.18A 4l8fD-4jxkA:
2.5		 4l8fD-4jxkA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		4 / 6 ARG A 121
ALA A 125
ASP A 301
LEU A 295
 None
 0.75A 4ot2A-4jxkA:
undetectable		 4ot2A-4jxkA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 11 LEU A 282
PHE A 131
ALA A 134
ILE A  66
ASP A  67
 None
 1.31A 4uuuA-4jxkA:
undetectable
4uuuB-4jxkA:
undetectable		 4uuuA-4jxkA:
24.72
4uuuB-4jxkA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4J_A_DMEA608_1
(ACETYLCHOLINESTERASE)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 9 TRP A 283
TYR A  91
PHE A 131
TYR A 274
GLY A 127
 None
 1.45A 5e4jA-4jxkA:
0.4		 5e4jA-4jxkA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 10 ALA A 240
ILE A 235
GLY A 150
GLY A 238
VAL A 152
 None
 1.26A 5i6xA-4jxkA:
undetectable		 5i6xA-4jxkA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 12 GLY A 162
GLY A 159
ASP A 221
VAL A 220
ALA A 129
 None
None
None
None
EDO  A 401 (-3.6A)
 1.17A 5kpcB-4jxkA:
5.1		 5kpcB-4jxkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 12 ASP A  67
ALA A  47
THR A 247
ARG A 322
GLY A 160
 None
None
None
EDO  A 402 (-4.0A)
EDO  A 402 (-3.6A)
 1.08A 5m5cB-4jxkA:
2.1		 5m5cB-4jxkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 12 VAL A 307
GLY A 100
GLY A  65
VAL A  42
ALA A 102
 None
None
None
EDO  A 402 (-4.8A)
None
 1.15A 5x7fA-4jxkA:
7.5		 5x7fA-4jxkA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4jxk OXIDOREDUCTASE
(Rhodococcus
opacus) 		5 / 12 VAL A 325
VAL A 161
SER A 244
VAL A  42
ASN A  43
 None
None
None
EDO  A 402 (-4.8A)
EDO  A 401 (-4.5A)
 1.46A 6h7lA-4jxkA:
undetectable		 6h7lA-4jxkA:
17.01