SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jxn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Roseobacter
denitrificans) 		5 / 12 LEU A 321
LEU A  60
TYR A 208
ASP A 200
ALA A 197
 None
 1.06A 2br4E-4jxnA:
undetectable		 2br4E-4jxnA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Roseobacter
denitrificans) 		5 / 9 PHE A 184
GLY A 209
GLU A 207
ALA A 187
VAL A  82
 None
 1.37A 2drdA-4jxnA:
1.2		 2drdA-4jxnA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Roseobacter
denitrificans) 		5 / 10 LEU A  90
LYS A 179
THR A 180
GLN A 217
LYS A 244
 None
 1.06A 2o1oB-4jxnA:
23.8		 2o1oB-4jxnA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Roseobacter
denitrificans) 		5 / 9 ILE A 218
ILE A 214
LEU A 173
GLU A 169
LYS A 251
 None
 1.48A 3f78A-4jxnA:
undetectable		 3f78A-4jxnA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Roseobacter
denitrificans) 		3 / 3 ARG A 177
GLU A 189
ASP A 199
 None
 0.94A 3g2oA-4jxnA:
undetectable		 3g2oA-4jxnA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Roseobacter
denitrificans) 		4 / 8 ASN A 146
THR A 150
ALA A 186
SER A 185
 None
 1.04A 3kp6A-4jxnA:
undetectable		 3kp6A-4jxnA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Roseobacter
denitrificans) 		4 / 7 ALA A 262
ALA A 256
ASP A 257
ARG A 261
 None
 0.72A 3ur0B-4jxnA:
undetectable		 3ur0B-4jxnA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Roseobacter
denitrificans) 		5 / 12 ALA A 298
THR A 294
VAL A 176
LEU A 173
ILE A 250
 None
 1.09A 4g1bA-4jxnA:
undetectable		 4g1bA-4jxnA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Roseobacter
denitrificans) 		5 / 11 ALA A 187
GLU A 189
GLY A 213
HIS A  86
GLU A  83
 None
 1.33A 4j83A-4jxnA:
undetectable		 4j83A-4jxnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Roseobacter
denitrificans) 		4 / 7 LEU A  78
THR A  61
GLY A 192
ALA A  65
 None
 0.73A 4yjiA-4jxnA:
undetectable		 4yjiA-4jxnA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Roseobacter
denitrificans) 		5 / 10 GLY A 192
GLY A 191
ALA A  64
HIS A  66
GLY A  69
 None
 0.85A 6e5zA-4jxnA:
undetectable		 6e5zA-4jxnA:
23.28