SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQG_A_IBPA701_1 (PROSTAGLANDIN H2 SYNTHASE-1)	4jxt	REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1A (Homo sapiens)	5 / 9	TYR A 117 LEU A 125 ILE A 67 ALA A 63 LEU A 60	UNX A 202 ( 4.9A) None None None None	1.01A	1eqgA-4jxtA: undetectable	1eqgA-4jxtA: 11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQG_B_IBPB1701_1 (PROSTAGLANDIN H2 SYNTHASE-1)	4jxt	REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1A (Homo sapiens)	5 / 11	TYR A 117 LEU A 125 ILE A 67 ALA A 63 LEU A 60	UNX A 202 ( 4.9A) None None None None	1.02A	1eqgB-4jxtA: undetectable	1eqgB-4jxtA: 11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AYL_B_FLPB2701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	4jxt	REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1A (Homo sapiens)	5 / 12	TYR A 117 LEU A 125 ILE A 67 ALA A 63 LEU A 60	UNX A 202 ( 4.9A) None None None None	1.05A	2aylB-4jxtA: undetectable	2aylB-4jxtA: 12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AZS_A_SAMA1475_1 (METHYLTRANSFERASE WBDD)	4jxt	REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1A (Homo sapiens)	3 / 3	ARG A 106 ASP A 65 GLN A 24	None UNX A 205 (-2.9A) UNX A 205 ( 4.7A)	0.82A	4azsA-4jxtA: undetectable	4azsA-4jxtA: 13.26

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EQG_A_IBPA701_1","PROSTAGLANDIN H2 SYNTHASE-1","4jxt","REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1A","Homo sapiens",5,"TYR A 117;LEU A 125;ILE A  67;ALA A  63;LEU A  60","UNX A 202 ( 4.9A);None;None;None;None","1.01A","1eqgA-4jxtA:undetectable","1eqgA-4jxtA:11.62"],["1EQG_B_IBPB1701_1","PROSTAGLANDIN H2 SYNTHASE-1","4jxt","REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1A","Homo sapiens",5,"TYR A 117;LEU A 125;ILE A  67;ALA A  63;LEU A  60","UNX A 202 ( 4.9A);None;None;None;None","1.02A","1eqgB-4jxtA:undetectable","1eqgB-4jxtA:11.62"],["2AYL_B_FLPB2701_1","PROSTAGLANDIN G\/H SYNTHASE 1","4jxt","REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1A","Homo sapiens",5,"TYR A 117;LEU A 125;ILE A  67;ALA A  63;LEU A  60","UNX A 202 ( 4.9A);None;None;None;None","1.05A","2aylB-4jxtA:undetectable","2aylB-4jxtA:12.84"],["4AZS_A_SAMA1475_1","METHYLTRANSFERASE WBDD","4jxt","REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1A","Homo sapiens",3,"ARG A 106;ASP A  65;GLN A  24","None;UNX A 205 (-2.9A);UNX A 205 ( 4.7A)","0.82A","4azsA-4jxtA:undetectable","4azsA-4jxtA:13.26"]]