SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A 289
ASP A 211
ASP A 212
ILE A 167
GLY A 204
 None
 0.99A 1d4sA-4jxyA:
undetectable		 1d4sA-4jxyA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A 289
ASP A 211
ASP A 212
ILE A 167
GLY A 204
 None
 1.02A 1d4yA-4jxyA:
undetectable		 1d4yA-4jxyA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		4 / 8 VAL A 111
SER A 108
ASN A 105
ASP A  85
 None
 1.15A 1hwiB-4jxyA:
undetectable		 1hwiB-4jxyA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		4 / 7 VAL A 111
SER A 108
ASN A 105
ASP A  85
 None
 1.08A 1hwiC-4jxyA:
undetectable		 1hwiC-4jxyA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		4 / 7 VAL A 111
SER A 108
ASN A 105
ASP A  85
 None
 1.08A 1hwiD-4jxyA:
undetectable		 1hwiD-4jxyA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		4 / 8 VAL A 111
SER A 108
ASN A 105
ASP A  85
 None
 1.16A 1hwkA-4jxyA:
undetectable		 1hwkA-4jxyA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		4 / 8 VAL A 111
SER A 108
ASN A 105
ASP A  85
 None
 1.16A 1hwkC-4jxyA:
undetectable		 1hwkC-4jxyA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		4 / 8 VAL A 111
SER A 108
ASN A 105
ASP A  85
 None
 1.15A 1hwkD-4jxyA:
undetectable		 1hwkD-4jxyA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		3 / 3 ALA A 315
HIS A 316
VAL A 319
 None
 0.41A 1lqtB-4jxyA:
undetectable		 1lqtB-4jxyA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		3 / 3 ALA A 315
HIS A 316
VAL A 319
 None
 0.45A 1lquB-4jxyA:
undetectable		 1lquB-4jxyA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_A_RIOA500_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 9 ASP A 212
ASP A 230
GLU A 233
GLY A 234
ASP A  84
 None
 1.47A 1m4gA-4jxyA:
undetectable		 1m4gA-4jxyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.98A 1rqjA-4jxyA:
28.7		 1rqjA-4jxyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.94A 1rqjA-4jxyA:
28.7		 1rqjA-4jxyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.95A 1rqjB-4jxyA:
28.5		 1rqjB-4jxyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.92A 1rqjB-4jxyA:
28.5		 1rqjB-4jxyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 12 ILE A  73
ILE A  72
ALA A  71
LEU A 185
ILE A  61
 None
 1.05A 1xzxX-4jxyA:
undetectable		 1xzxX-4jxyA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.89A 1yhlA-4jxyA:
24.9		 1yhlA-4jxyA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.82A 1yhlA-4jxyA:
24.9		 1yhlA-4jxyA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.98A 1yq7A-4jxyA:
25.0		 1yq7A-4jxyA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.88A 1yq7A-4jxyA:
25.0		 1yq7A-4jxyA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.87A 1yv5A-4jxyA:
25.3		 1yv5A-4jxyA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.85A 1yv5A-4jxyA:
25.3		 1yv5A-4jxyA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.89A 2f8cF-4jxyA:
25.8		 2f8cF-4jxyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.87A 2f8cF-4jxyA:
25.8		 2f8cF-4jxyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.84A 2f8zF-4jxyA:
26.0		 2f8zF-4jxyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.83A 2f8zF-4jxyA:
26.0		 2f8zF-4jxyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 12 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.92A 2f94F-4jxyA:
25.6		 2f94F-4jxyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 12 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.91A 2f94F-4jxyA:
25.6		 2f94F-4jxyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.92A 2f9kF-4jxyA:
25.8		 2f9kF-4jxyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.83A 2f9kF-4jxyA:
25.8		 2f9kF-4jxyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
LYS A 235
 None
 0.75A 2o1oB-4jxyA:
25.0		 2o1oB-4jxyA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A 289
ASP A 211
ASP A 212
ILE A 167
GLY A 204
 None
 1.04A 2o4pA-4jxyA:
undetectable		 2o4pA-4jxyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 212
 None
 0.65A 2q58A-4jxyA:
24.1		 2q58A-4jxyA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.99A 3ez3D-4jxyA:
24.7		 3ez3D-4jxyA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.83A 3ez3D-4jxyA:
24.7		 3ez3D-4jxyA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.92A 3n45F-4jxyA:
25.9		 3n45F-4jxyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.84A 3n45F-4jxyA:
25.9		 3n45F-4jxyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.89A 3n46F-4jxyA:
25.6		 3n46F-4jxyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.82A 3n46F-4jxyA:
25.6		 3n46F-4jxyA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		4 / 5 LEU A 238
GLN A 286
THR A 284
GLU A 160
 None
 1.16A 3n58C-4jxyA:
undetectable		 3n58C-4jxyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 9 GLY A 183
ARG A 130
LEU A 181
LEU A 180
ILE A 134
 None
GUA  A 402 (-3.7A)
None
GUA  A 402 (-4.8A)
GUA  A 402 (-4.0A)
 1.40A 3nbqD-4jxyA:
undetectable		 3nbqD-4jxyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A 289
ASP A 211
ASP A 212
ILE A 167
GLY A 204
 None
 1.13A 3spkA-4jxyA:
undetectable		 3spkA-4jxyA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		4 / 8 ASP A 212
GLU A 146
ASP A 230
GLU A 233
 None
 1.08A 4feuD-4jxyA:
undetectable		 4feuD-4jxyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		4 / 7 ASP A 212
GLU A 146
ASP A 230
GLU A 233
 None
 1.06A 4fevB-4jxyA:
undetectable		 4fevB-4jxyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		4 / 8 ASP A 212
GLU A 146
ASP A 230
GLU A 233
 None
 1.12A 4gkhD-4jxyA:
undetectable		 4gkhD-4jxyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.90A 4kpdA-4jxyA:
25.7		 4kpdA-4jxyA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.90A 4kpdA-4jxyA:
25.7		 4kpdA-4jxyA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 9 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.93A 4kpjA-4jxyA:
25.5		 4kpjA-4jxyA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 9 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.86A 4kpjA-4jxyA:
25.5		 4kpjA-4jxyA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.92A 4kq5A-4jxyA:
25.4		 4kq5A-4jxyA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.87A 4kq5A-4jxyA:
25.4		 4kq5A-4jxyA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.91A 4kqsA-4jxyA:
25.9		 4kqsA-4jxyA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.86A 4kqsA-4jxyA:
25.9		 4kqsA-4jxyA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 12 LEU A 289
ASP A 211
ASP A 212
ILE A 167
GLY A 204
 None
 1.01A 4njuA-4jxyA:
undetectable		 4njuA-4jxyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 12 LEU A 289
ASP A 211
ASP A 212
ILE A 167
GLY A 204
 None
 1.04A 4njuC-4jxyA:
undetectable		 4njuC-4jxyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.92A 4nkeA-4jxyA:
25.4		 4nkeA-4jxyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.87A 4nkeA-4jxyA:
25.4		 4nkeA-4jxyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 9 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.95A 4nkfA-4jxyA:
25.7		 4nkfA-4jxyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 9 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.87A 4nkfA-4jxyA:
25.7		 4nkfA-4jxyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.91A 4nuaA-4jxyA:
25.7		 4nuaA-4jxyA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.85A 4nuaA-4jxyA:
25.7		 4nuaA-4jxyA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 9 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.91A 4oguA-4jxyA:
25.4		 4oguA-4jxyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 9 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.85A 4oguA-4jxyA:
25.4		 4oguA-4jxyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.91A 4p0wA-4jxyA:
25.8		 4p0wA-4jxyA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 11 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.91A 4p0wA-4jxyA:
25.8		 4p0wA-4jxyA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.93A 4rxdA-4jxyA:
24.1		 4rxdA-4jxyA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.85A 4rxdA-4jxyA:
24.1		 4rxdA-4jxyA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.92A 4rxdB-4jxyA:
24.4		 4rxdB-4jxyA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.86A 4rxdB-4jxyA:
24.4		 4rxdB-4jxyA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.93A 4rxdC-4jxyA:
24.3		 4rxdC-4jxyA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 10 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.85A 4rxdC-4jxyA:
24.3		 4rxdC-4jxyA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		3 / 3 MET A 214
GLN A 287
TYR A 283
 None
 0.59A 4udcA-4jxyA:
2.7		 4udcA-4jxyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 12 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.93A 5cg5A-4jxyA:
25.2		 5cg5A-4jxyA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 12 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.86A 5cg5A-4jxyA:
25.2		 5cg5A-4jxyA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 12 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
 None
 0.92A 5cg6A-4jxyA:
25.6		 5cg6A-4jxyA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 12 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
 0.86A 5cg6A-4jxyA:
25.6		 5cg6A-4jxyA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		3 / 3 ALA A  56
GLN A  62
THR A 186
 None
 0.58A 5n0oA-4jxyA:
undetectable		 5n0oA-4jxyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		5 / 12 GLU A  74
ARG A  46
GLY A  44
LEU A 126
ILE A  73
 None
 1.21A 5vooA-4jxyA:
undetectable		 5vooA-4jxyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE
(Pseudoalteromona
s
atlantica) 		4 / 7 ASP A  84
LYS A 170
GLN A 208
LYS A 235
 None
 1.39A 6g31A-4jxyA:
25.6		 6g31A-4jxyA:
13.12