SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jy4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 8 VAL A 106
ARG A  61
ALA A  19
GLU A  83
 None
None
None
GOL  A 301 (-3.9A)
 0.91A 1dmiA-4jy4A:
undetectable
1dmiB-4jy4A:
undetectable		 1dmiA-4jy4A:
20.18
1dmiB-4jy4A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 4jy4 PGT121 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 ARG B  66
SER B  60
LEU B  20
LEU B  18
ASP B  86
 None
 1.36A 1e7wA-4jy4B:
undetectable		 1e7wA-4jy4B:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 GLY B 137
ALA B 134
HIS B 162
THR A 117
 None
 0.82A 1gtfL-4jy4B:
undetectable
1gtfM-4jy4B:
undetectable		 1gtfL-4jy4B:
14.10
1gtfM-4jy4B:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLY B 137
ALA B 134
HIS B 162
THR A 117
 None
 0.81A 1gtfN-4jy4B:
undetectable
1gtfO-4jy4B:
undetectable		 1gtfN-4jy4B:
14.10
1gtfO-4jy4B:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 104
THR B 105
ALA B  93
GLY A  41
HIS A  38
 None
None
None
FUC  B 310 ( 4.5A)
None
 1.31A 1nbiC-4jy4B:
undetectable		 1nbiC-4jy4B:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 104
THR B 105
ALA B  93
GLY A  41
HIS A  38
 None
None
None
FUC  B 310 ( 4.5A)
None
 1.30A 1nbiD-4jy4B:
undetectable		 1nbiD-4jy4B:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4jy4 PGT121 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 GLY B  88
THR B 105
ALA B  85
THR B  83
ALA B  82
 None
 0.97A 2gluA-4jy4B:
undetectable		 2gluA-4jy4B:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 4jy4 PGT121 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 GLY B  88
THR B 105
ALA B  85
THR B  83
ALA B  82
 None
 1.02A 2gluB-4jy4B:
undetectable		 2gluB-4jy4B:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 7 TYR A  36
HIS A  38
PRO A  44
TYR A  87
TYR B  91
 None
 0.37A 2oldA-4jy4A:
19.1
2oldB-4jy4A:
18.4		 2oldA-4jy4A:
74.09
2oldB-4jy4A:
74.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR B  91
TYR A  36
PRO A  44
TYR A  87
 None
 0.42A 2oldA-4jy4B:
13.1
2oldB-4jy4B:
16.4		 2oldA-4jy4B:
32.38
2oldB-4jy4B:
32.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 TYR A  36
HIS A  38
PRO A  44
TYR A  87
 None
 0.35A 2ombC-4jy4A:
18.3
2ombD-4jy4A:
19.2		 2ombC-4jy4A:
74.09
2ombD-4jy4A:
74.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR A  36
HIS A  38
PRO A  44
TYR B  91
 None
 0.74A 2ombC-4jy4A:
18.3
2ombD-4jy4A:
19.2		 2ombC-4jy4A:
74.09
2ombD-4jy4A:
74.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 6 LEU A 133
ALA A 131
LEU A 179
THR A 182
 None
 1.08A 3cfqA-4jy4A:
undetectable		 3cfqA-4jy4A:
22.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GKZ_A_B40A500_1
(ANTI-METHAMPHETAMINE
SINGLE CHAIN FV)		 4jy4 PGT121 HEAVY CHAIN
PGT121 LIGHT CHAIN
(Homo
sapiens) 		5 / 11 TYR B  33
SER B  35
TYR B  50
TYR A  36
HIS A  89
 None
 1.14A 3gkzA-4jy4B:
18.0		 3gkzA-4jy4B:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GM0_A_B41A600_1
(ANTI-METHAMPHETAMINE
SINGLE CHAIN FV)		 4jy4 PGT121 HEAVY CHAIN
PGT121 LIGHT CHAIN
(Homo
sapiens) 		5 / 11 TYR B  33
SER B  35
TYR B  50
TYR A  36
HIS A  89
 None
 1.16A 3gm0A-4jy4B:
17.4		 3gm0A-4jy4B:
35.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4jy4 PGT121 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU B 187
GLY B 188
ALA B 123
PRO B 124
 None
 0.50A 3huoA-4jy4B:
undetectable		 3huoA-4jy4B:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4jy4 PGT121 HEAVY CHAIN
(Homo
sapiens) 		3 / 3 VAL B  51
VAL B  67
SER B  81
 None
 0.71A 3n8xB-4jy4B:
undetectable		 3n8xB-4jy4B:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 8 THR A  74
TYR A  86
TRP A  35
ARG A  20
 None
 1.45A 3wipB-4jy4A:
3.1
3wipC-4jy4A:
3.1		 3wipB-4jy4A:
23.43
3wipC-4jy4A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 8 THR A  74
TYR A  86
TRP A  35
ARG A  20
 None
 1.44A 3wipC-4jy4A:
3.1
3wipD-4jy4A:
3.1		 3wipC-4jy4A:
23.43
3wipD-4jy4A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 6 LEU A 133
ALA A 131
LEU A 179
THR A 182
 None
 1.04A 4i89A-4jy4A:
3.0		 4i89A-4jy4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 6 LEU A 133
ALA A 131
LEU A 179
THR A 182
 None
 1.04A 4ikiB-4jy4A:
undetectable		 4ikiB-4jy4A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4jy4 PGT121 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LEU B  69
ILE B  37
TYR B  90
LEU B  20
GLY B 102
 None
 1.35A 4l9qA-4jy4B:
undetectable		 4l9qA-4jy4B:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 6 LEU A 133
ALA A 131
LEU A 179
THR A 182
 None
 1.02A 5bojA-4jy4A:
undetectable		 5bojA-4jy4A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 THR A 117
GLY B 137
ALA B 134
HIS B 162
 None
 0.80A 5eezL-4jy4A:
undetectable
5eezV-4jy4A:
undetectable		 5eezL-4jy4A:
16.75
5eezV-4jy4A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 THR A 117
GLY B 137
ALA B 134
HIS B 162
 None
 0.80A 5ef1L-4jy4A:
undetectable
5ef1V-4jy4A:
undetectable		 5ef1L-4jy4A:
16.75
5ef1V-4jy4A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 THR A 117
GLY B 137
ALA B 134
HIS B 162
 None
 0.80A 5ef2L-4jy4A:
undetectable
5ef2V-4jy4A:
undetectable		 5ef2L-4jy4A:
16.75
5ef2V-4jy4A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 ASP A   9
ASP A  85
TYR A  87
GLY A 100
 None
GOL  A 301 ( 4.9A)
None
None
 1.12A 5hwaA-4jy4A:
undetectable		 5hwaA-4jy4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jy4 PGT121 HEAVY CHAIN
(Homo
sapiens) 		3 / 3 LEU B  63
TYR B  90
SER B  40
 None
 0.85A 5iktA-4jy4B:
undetectable		 5iktA-4jy4B:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4jy4 PGT121 HEAVY CHAIN
PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 5 TYR A  87
GLY A 101
THR A 102
GLY B 172
 None
 0.68A 5jlcA-4jy4A:
undetectable		 5jlcA-4jy4A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 6 LEU A 133
ALA A 131
LEU A 179
THR A 182
 None
 0.98A 5l4iA-4jy4A:
undetectable		 5l4iA-4jy4A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 6 LEU A 133
ALA A 131
LEU A 179
THR A 182
 None
 1.00A 5l4iB-4jy4A:
undetectable		 5l4iB-4jy4A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER B 128
SER A 115
PHE A 119
 None
 0.82A 5mugA-4jy4B:
undetectable		 5mugA-4jy4B:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4jy4 PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 4 ASN A  50
SER A  30
ALA A  32
VAL A  33
 None
 1.15A 5nm5A-4jy4A:
undetectable		 5nm5A-4jy4A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4jy4 PGT121 HEAVY CHAIN
PGT121 LIGHT CHAIN
(Homo
sapiens) 		4 / 8 PRO B 165
THR A 162
THR A 163
PRO A 114
 None
 1.34A 5x2sI-4jy4B:
undetectable
5x2sJ-4jy4B:
undetectable
5x2sK-4jy4B:
undetectable		 5x2sI-4jy4B:
20.25
5x2sJ-4jy4B:
19.74
5x2sK-4jy4B:
20.25