SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jy6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GKZ_A_B40A500_1
(ANTI-METHAMPHETAMINE
SINGLE CHAIN FV)		 4jy6 PGT123 HEAVY CHAIN
PGT123 LIGHT CHAIN
(Homo
sapiens) 		5 / 11 TYR B  33
SER B  35
TYR B  50
TYR A  36
HIS A  89
 None
 1.16A 3gkzA-4jy6B:
17.0		 3gkzA-4jy6B:
33.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4jy6 PGT123 HEAVY CHAIN
PGT123 LIGHT CHAIN
(Homo
sapiens) 		5 / 12 PHE B 164
SER A 179
VAL A 150
VAL A 148
PHE A 143
 None
 1.31A 3nbrA-4jy6B:
undetectable		 3nbrA-4jy6B:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4jy6 PGT123 HEAVY CHAIN
(Homo
sapiens) 		5 / 10 VAL B 109
ALA B  85
LEU B  20
VAL B 107
THR B  83
 None
 1.26A 4eilB-4jy6B:
undetectable		 4eilB-4jy6B:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4jy6 PGT123 HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL B 109
ALA B  85
LEU B  20
VAL B 107
THR B  83
 None
 1.27A 4eilC-4jy6B:
undetectable		 4eilC-4jy6B:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4jy6 PGT123 HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL B 109
ALA B  85
LEU B  20
VAL B 107
THR B  83
 None
 1.26A 4eilE-4jy6B:
undetectable		 4eilE-4jy6B:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GQP_H_B40H1201_1
(ANTI-METH SCFV)		 4jy6 PGT123 HEAVY CHAIN
PGT123 LIGHT CHAIN
(Homo
sapiens) 		5 / 11 TYR B  33
SER B  35
TYR B  50
TYR A  36
HIS A  89
 None
 1.18A 4gqpH-4jy6B:
17.0		 4gqpH-4jy6B:
35.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4jy6 PGT123 HEAVY CHAIN
PGT123 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 VAL B 167
SER A 183
GLN B 169
LEU B 139
 None
 1.19A 4hxyB-4jy6B:
undetectable		 4hxyB-4jy6B:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4jy6 PGT123 HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL B 109
ALA B  85
LEU B  20
VAL B 107
THR B  83
 None
 1.29A 4kyaA-4jy6B:
undetectable		 4kyaA-4jy6B:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4jy6 PGT123 HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL B 109
ALA B  85
LEU B  20
VAL B 107
THR B  83
 None
 1.30A 4kyaG-4jy6B:
undetectable		 4kyaG-4jy6B:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4jy6 PGT123 HEAVY CHAIN
(Homo
sapiens) 		5 / 11 TRP B  36
GLY B  49
ILE B  29
SER B  28
TYR B  50
 None
 1.50A 4rtrA-4jy6B:
undetectable		 4rtrA-4jy6B:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4jy6 PGT123 LIGHT CHAIN
(Homo
sapiens) 		4 / 4 ASN A  50
SER A  30
ALA A  32
VAL A  33
 ZN  A 307 ( 4.0A)
None
None
None
 1.13A 5nm5A-4jy6A:
undetectable		 5nm5A-4jy6A:
19.35