SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4jyk HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RUTR
(Escherichia
coli) 		3 / 3 ARG A 189
GLN A 110
PRO A 109
 None
 0.95A 2qhfA-4jykA:
undetectable		 2qhfA-4jykA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4jyk HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RUTR
(Escherichia
coli) 		5 / 12 ALA A 168
HIS A 172
MET A 119
ALA A 123
LEU A 130
 None
 1.28A 3tm4A-4jykA:
2.3		 3tm4A-4jykA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4jyk HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RUTR
(Escherichia
coli) 		5 / 12 ALA A 168
HIS A 172
MET A 119
ALA A 123
LEU A 130
 None
 1.27A 3tm4B-4jykA:
2.3		 3tm4B-4jykA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4jyk HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RUTR
(Escherichia
coli) 		4 / 8 TRP A 148
LEU A  91
ILE A  94
ILE A 145
 None
SO4  A 302 (-3.6A)
None
None
 0.91A 3wxoA-4jykA:
undetectable		 3wxoA-4jykA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4jyk HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RUTR
(Escherichia
coli) 		4 / 7 ILE A 145
VAL A 149
PRO A  90
ILE A 157
 None
None
SO4  A 302 (-3.7A)
None
 0.97A 6cduF-4jykA:
3.2
6cduG-4jykA:
3.0		 6cduF-4jykA:
19.12
6cduG-4jykA:
19.12