SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jyp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ALA A  98
VAL A  92
TRP A  33
 None
 0.82A 1av2C-4jypA:
undetectable
1av2D-4jypA:
undetectable		 1av2C-4jypA:
9.80
1av2D-4jypA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		4 / 6 PRO A 253
GLN A 249
LYS A  34
VAL A  37
 None
 1.48A 1l2iB-4jypA:
undetectable		 1l2iB-4jypA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ALA A  98
VAL A  92
TRP A  33
 None
 0.86A 1nt6A-4jypA:
undetectable		 1nt6A-4jypA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ALA A  98
VAL A  92
TRP A  33
 None
 0.86A 1nt6B-4jypA:
undetectable		 1nt6B-4jypA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		4 / 8 ILE A  80
LEU A  77
PHE A  91
GLY A  93
 None
 1.05A 1os6A-4jypA:
undetectable		 1os6A-4jypA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		4 / 6 LYS A  34
LEU A 250
LEU A 247
SER A  95
 None
 1.01A 1tz8C-4jypA:
undetectable
1tz8D-4jypA:
undetectable		 1tz8C-4jypA:
18.45
1tz8D-4jypA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		5 / 10 TYR A 124
ALA A 158
PHE A 157
GLY A  25
PHE A  26
 None
 1.26A 1uhoA-4jypA:
undetectable		 1uhoA-4jypA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ARG A 123
ARG A 199
ILE A 201
 None
 0.80A 1uobA-4jypA:
undetectable		 1uobA-4jypA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ALA A  98
VAL A  92
TRP A  33
 None
 0.85A 1w5uC-4jypA:
undetectable
1w5uD-4jypA:
undetectable		 1w5uC-4jypA:
9.80
1w5uD-4jypA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		4 / 5 ILE A  86
PHE A 112
PHE A  91
ILE A  78
 None
 0.94A 2hjhA-4jypA:
undetectable		 2hjhA-4jypA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		4 / 4 LEU A 178
ALA A 161
VAL A 162
PRO A 159
 None
 1.22A 3gv1B-4jypA:
0.8		 3gv1B-4jypA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		5 / 10 ILE A 241
VAL A 259
ILE A 260
ILE A 118
SER A 119
 None
 1.42A 3kpbD-4jypA:
undetectable		 3kpbD-4jypA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		3 / 3 ALA A  98
VAL A  92
TRP A  33
 None
 0.86A 3l8lC-4jypA:
undetectable
3l8lD-4jypA:
undetectable		 3l8lC-4jypA:
9.80
3l8lD-4jypA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		4 / 6 ILE A 100
ASP A  60
GLY A  53
VAL A   4
 None
 0.83A 3n3iA-4jypA:
undetectable		 3n3iA-4jypA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		4 / 8 ALA A  54
GLY A  55
THR A  56
THR A 177
 None
 0.76A 3rglA-4jypA:
undetectable		 3rglA-4jypA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		4 / 6 ILE A  80
LEU A  77
PHE A  91
GLY A  93
 None
 0.91A 3sj1X-4jypA:
undetectable		 3sj1X-4jypA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		4 / 7 ILE A  80
LEU A  77
PHE A  91
GLY A  93
 None
 0.91A 4hbfA-4jypA:
undetectable		 4hbfA-4jypA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		4 / 7 ILE A  80
LEU A  77
PHE A  91
GLY A  93
 None
 1.01A 4hc3A-4jypA:
undetectable		 4hc3A-4jypA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		4 / 6 TYR A  73
TYR A  49
GLY A  53
ASP A 184
 None
 1.28A 5emlA-4jypA:
2.1		 5emlA-4jypA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR A 130
SER A 121
MET A  99
VAL A 224
LEU A 232
 None
 1.44A 5g6sB-4jypA:
undetectable
5g6sC-4jypA:
undetectable		 5g6sB-4jypA:
23.92
5g6sC-4jypA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		5 / 11 THR A  57
ALA A   7
GLU A   5
ALA A  54
LEU A  81
 None
 1.08A 5lf7V-4jypA:
undetectable
5lf7W-4jypA:
undetectable		 5lf7V-4jypA:
21.58
5lf7W-4jypA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		5 / 12 SER A  74
VAL A  21
GLY A  23
SER A  97
PHE A 112
 None
 1.40A 6a94A-4jypA:
undetectable		 6a94A-4jypA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		6 / 12 PHE A  26
VAL A  96
PHE A 134
TRP A 153
PHE A 157
HIS A 246
 None
 0.51A 6ap6A-4jypA:
43.2		 6ap6A-4jypA:
54.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PHE A  26
VAL A  96
PHE A 134
TRP A 153
PHE A 194
 None
 1.06A 6ap6A-4jypA:
43.2		 6ap6A-4jypA:
54.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		6 / 12 PHE A  26
VAL A  96
PHE A 134
TRP A 153
PHE A 157
HIS A 246
 None
 0.53A 6ap6B-4jypA:
43.1		 6ap6B-4jypA:
54.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PHE A  26
VAL A  96
PHE A 134
TRP A 153
PHE A 194
 None
 1.07A 6ap6B-4jypA:
43.1		 6ap6B-4jypA:
54.24