SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jys PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
vivax) 		5 / 10 ARG A 157
GLY A 111
GLU A 180
SER A 122
ILE A 120
 None
 1.41A 1pw7A-4jysA:
undetectable		 1pw7A-4jysA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 4jys PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
vivax) 		5 / 9 ILE A  99
ILE A 150
VAL A 183
TYR A  88
ILE A 148
 None
 1.28A 3p4wA-4jysA:
undetectable		 3p4wA-4jysA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 4jys PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
vivax) 		4 / 7 TYR A 168
ILE A 142
THR A 113
THR A 114
 None
 0.88A 3tneB-4jysA:
undetectable		 3tneB-4jysA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 4jys PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
vivax) 		4 / 8 VAL A 149
TYR A  88
CYH A 160
ILE A 107
 None
 0.88A 4afgD-4jysA:
undetectable
4afgE-4jysA:
undetectable		 4afgD-4jysA:
21.84
4afgE-4jysA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4jys PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
vivax) 		5 / 10 ILE A  99
ILE A 150
VAL A 183
TYR A  88
ILE A 148
 None
 1.23A 5mvnD-4jysA:
undetectable		 5mvnD-4jysA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 4jys PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
vivax) 		5 / 10 ILE A  99
ILE A 150
VAL A 183
TYR A  88
ILE A 148
 None
 1.22A 5mzrA-4jysA:
undetectable		 5mzrA-4jysA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 4jys PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
vivax) 		5 / 10 ILE A  99
ILE A 150
VAL A 183
TYR A  88
ILE A 148
 None
 1.22A 5mzrC-4jysA:
undetectable		 5mzrC-4jysA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4jys PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Plasmodium
vivax) 		5 / 9 ILE A  99
ILE A 150
VAL A 183
TYR A  88
ILE A 148
 None
 1.21A 5mzrD-4jysA:
undetectable		 5mzrD-4jysA:
15.94