SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA8_0
(MINI-GRAMICIDIN A)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		4 / 5 TRP A 195
TRP A 161
ALA A 108
TRP A 159
 None
 1.12A 1kqeA-4jz2A:
undetectable
1kqeE-4jz2A:
undetectable		 1kqeA-4jz2A:
5.22
1kqeE-4jz2A:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		4 / 6 HIS A  56
ASP A  42
TYR A  39
HIS A  60
 CO  A 301 (-3.3A)
None
None
None
 1.48A 2dysN-4jz2A:
undetectable
2dysP-4jz2A:
undetectable		 2dysN-4jz2A:
17.50
2dysP-4jz2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		4 / 6 HIS A  56
ASP A  42
TYR A  39
HIS A  60
 CO  A 301 (-3.3A)
None
None
None
 1.47A 2eimA-4jz2A:
undetectable
2eimC-4jz2A:
undetectable		 2eimA-4jz2A:
17.50
2eimC-4jz2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		4 / 6 HIS A  56
ASP A  42
TYR A  39
HIS A  60
 CO  A 301 (-3.3A)
None
None
None
 1.50A 2einA-4jz2A:
undetectable
2einC-4jz2A:
undetectable		 2einA-4jz2A:
17.50
2einC-4jz2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		5 / 10 THR A 175
PRO A 176
GLY A 158
LEU A  87
GLY A 106
 None
 1.15A 2vl2A-4jz2A:
undetectable
2vl2C-4jz2A:
undetectable		 2vl2A-4jz2A:
20.37
2vl2C-4jz2A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		4 / 7 HIS A  56
ASP A  42
TYR A  39
HIS A  60
 CO  A 301 (-3.3A)
None
None
None
 1.50A 3abkN-4jz2A:
undetectable
3abkP-4jz2A:
undetectable		 3abkN-4jz2A:
17.50
3abkP-4jz2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		5 / 9 LEU A 162
ILE A 190
GLY A 191
SER A 171
LEU A 170
 None
 1.00A 3ai9X-4jz2A:
undetectable		 3ai9X-4jz2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		5 / 12 VAL A 101
ALA A 105
GLY A 106
LEU A  78
PHE A  32
 None
 1.15A 3qxyA-4jz2A:
undetectable		 3qxyA-4jz2A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		5 / 11 VAL A 101
ALA A 105
GLY A 106
LEU A  78
PHE A  32
 None
 1.18A 3rc0A-4jz2A:
undetectable		 3rc0A-4jz2A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		5 / 12 VAL A 101
ALA A 105
GLY A 106
LEU A  78
PHE A  32
 None
 1.18A 3rc0B-4jz2A:
undetectable		 3rc0B-4jz2A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		3 / 3 ASP A  49
LYS A  54
LEU A  37
 None
 1.02A 4ptjA-4jz2A:
undetectable		 4ptjA-4jz2A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		4 / 4 LEU A 162
ILE A 190
PRO A 125
LEU A 129
 None
 1.21A 5eb3A-4jz2A:
undetectable		 5eb3A-4jz2A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		5 / 12 LEU A 162
ILE A 190
GLY A 191
SER A 171
LEU A 170
 None
 1.14A 5twjC-4jz2A:
undetectable		 5twjC-4jz2A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		4 / 7 THR A  52
HIS A  56
PHE A 114
MET A 118
 None
CO  A 301 (-3.3A)
None
None
 1.38A 5u6mA-4jz2A:
undetectable		 5u6mA-4jz2A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		4 / 7 THR A  52
HIS A  56
PHE A 114
MET A 118
 None
CO  A 301 (-3.3A)
None
None
 1.37A 5u6mB-4jz2A:
undetectable		 5u6mB-4jz2A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jz2 SUPEROXIDE DISMUTASE
(Clostridioides
difficile) 		3 / 3 ARG A 135
PHE A 140
LEU A 170
 None
 0.94A 5x1bC-4jz2A:
undetectable		 5x1bC-4jz2A:
19.22