SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jz7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  34
ALA A 301
LEU A 298
LEU A  51
ILE A   9
 None
 1.09A 1bsxA-4jz7A:
undetectable		 1bsxA-4jz7A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  34
ALA A 301
LEU A 298
LEU A  51
ILE A   9
 None
 1.09A 1bsxB-4jz7A:
undetectable		 1bsxB-4jz7A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.86A 1fm6A-4jz7A:
undetectable		 1fm6A-4jz7A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.83A 1k74A-4jz7A:
undetectable		 1k74A-4jz7A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ASP A 303
MET A 233
ASP A 217
ALA A  10
ILE A   9
 None
 1.29A 1s14B-4jz7A:
undetectable		 1s14B-4jz7A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 GLY A  56
GLY A  13
VAL A 213
VAL A  59
LEU A  78
 None
ANP  A1001 (-3.3A)
None
None
None
 0.93A 1vptA-4jz7A:
undetectable		 1vptA-4jz7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.87A 1xiuA-4jz7A:
undetectable		 1xiuA-4jz7A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.85A 1xiuB-4jz7A:
undetectable		 1xiuB-4jz7A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  96
VAL A   7
LEU A 235
 None
 0.96A 1xiuB-4jz7A:
undetectable		 1xiuB-4jz7A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.90A 1xlsA-4jz7A:
undetectable		 1xlsA-4jz7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.91A 1xlsB-4jz7A:
undetectable		 1xlsB-4jz7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.90A 1xlsC-4jz7A:
undetectable		 1xlsC-4jz7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.90A 1xlsD-4jz7A:
undetectable		 1xlsD-4jz7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ALA A  45
LEU A 305
VAL A 302
ILE A   9
LEU A 235
 None
 1.08A 2qk8A-4jz7A:
undetectable		 2qk8A-4jz7A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 10 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.83A 3falA-4jz7A:
undetectable		 3falA-4jz7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 11 ALA A  45
LEU A 305
VAL A 302
ILE A   9
LEU A 235
 None
 1.11A 3fl9C-4jz7A:
undetectable		 3fl9C-4jz7A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ALA A  45
LEU A 305
VAL A 302
ILE A   9
LEU A 235
 None
 1.05A 3fl9G-4jz7A:
undetectable		 3fl9G-4jz7A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 9 ALA A  45
LEU A 305
VAL A 302
ILE A   9
LEU A 235
 None
 1.07A 3fl9H-4jz7A:
1.8		 3fl9H-4jz7A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 THR A 286
THR A 289
ILE A 295
ILE A 234
LEU A 258
 None
 0.92A 3gwxA-4jz7A:
undetectable		 3gwxA-4jz7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.86A 3oapA-4jz7A:
undetectable		 3oapA-4jz7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 11 VAL A  32
ALA A  35
GLY A  54
LEU A 298
GLY A  13
 None
None
ANP  A1001 ( 4.6A)
None
ANP  A1001 (-3.3A)
 1.14A 3zosA-4jz7A:
undetectable
3zosB-4jz7A:
undetectable		 3zosA-4jz7A:
20.27
3zosB-4jz7A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A 180
ILE A   9
ASN A 194
MET A  97
LEU A 189
 None
 1.02A 4a81A-4jz7A:
undetectable		 4a81A-4jz7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		4 / 8 VAL A  49
MET A 233
ILE A   9
GLU A 106
 None
 1.05A 4a97G-4jz7A:
undetectable		 4a97G-4jz7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		4 / 8 VAL A  49
MET A 233
ILE A   9
GLU A 106
 None
 1.06A 4a97I-4jz7A:
undetectable		 4a97I-4jz7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 11 ILE A  39
ALA A  35
ALA A  96
VAL A   7
LEU A 235
 None
 1.09A 4nqaA-4jz7A:
undetectable		 4nqaA-4jz7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.89A 5uanA-4jz7A:
undetectable		 5uanA-4jz7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  96
VAL A   7
LEU A 235
 None
 1.00A 5uanA-4jz7A:
undetectable		 5uanA-4jz7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.82A 5z12B-4jz7A:
undetectable		 5z12B-4jz7A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  96
VAL A   7
LEU A 235
 None
 0.96A 5z12B-4jz7A:
undetectable		 5z12B-4jz7A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.89A 5z12C-4jz7A:
undetectable		 5z12C-4jz7A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 10 GLY A 196
GLY A  54
ASP A 217
THR A 193
ILE A 174
 None
ANP  A1001 ( 4.6A)
None
None
None
 0.90A 6exiA-4jz7A:
3.1		 6exiA-4jz7A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 10 GLY A 196
GLY A  54
ASP A 217
THR A 193
ILE A 174
 None
ANP  A1001 ( 4.6A)
None
None
None
 0.89A 6exiB-4jz7A:
2.7		 6exiB-4jz7A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 GLY A 196
GLY A  54
ASP A 217
THR A 193
ILE A 174
 None
ANP  A1001 ( 4.6A)
None
None
None
 0.90A 6exiC-4jz7A:
undetectable
6exiD-4jz7A:
undetectable		 6exiC-4jz7A:
14.61
6exiD-4jz7A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		5 / 12 GLY A 196
GLY A  54
ASP A 217
THR A 193
ILE A 174
 None
ANP  A1001 ( 4.6A)
None
None
None
 0.89A 6exiC-4jz7A:
2.5
6exiD-4jz7A:
undetectable		 6exiC-4jz7A:
14.61
6exiD-4jz7A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4jz7 CARBAMATE KINASE
(Giardia
intestinalis) 		4 / 5 ILE A 214
GLN A 116
THR A 117
LEU A  78
 None
 1.07A 6f3mD-4jz7A:
2.3		 6f3mD-4jz7A:
21.92