SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN
ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN
(Homo
sapiens) 		6 / 12 TYR B  35
GLN B  88
PHE B  97
VAL A  37
ALA A  97
TRP A 109
 None
 0.63A 1h8sA-4jznB:
18.2		 1h8sA-4jznB:
34.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4jzn ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 LEU B 134
THR B 171
SER B 161
THR B 163
 None
 0.81A 1ictD-4jznB:
undetectable		 1ictD-4jznB:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN
(Homo
sapiens) 		4 / 4 ALA A  40
ARG A  38
GLN A  43
GLU A  46
 None
 0.90A 1lqtB-4jznA:
undetectable		 1lqtB-4jznA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN
(Homo
sapiens) 		4 / 4 ALA A  40
ARG A  38
GLN A  43
GLU A  46
 None
 0.93A 1lquB-4jznA:
undetectable		 1lquB-4jznA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4jzn ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN
(Homo
sapiens) 		4 / 6 GLY B  23
GLN B   6
VAL B  32
ALA B  70
 None
 0.84A 1p6kA-4jznB:
undetectable		 1p6kA-4jznB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN
(Homo
sapiens) 		3 / 3 MET A  81
ASN A  85
GLN A  65
 None
 1.05A 1xoqB-4jznA:
undetectable		 1xoqB-4jznA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4jzn ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN
(Homo
sapiens) 		4 / 5 LEU B 178
GLY B 127
PRO B 119
VAL B 131
 None
 0.91A 2aojA-4jznB:
undetectable		 2aojA-4jznB:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN
ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR A  95
TYR B  35
PRO B  43
TYR B  86
 None
 0.71A 2oldA-4jznA:
20.2
2oldB-4jznA:
15.4		 2oldA-4jznA:
29.67
2oldB-4jznA:
29.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN
ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR B  35
PRO B  43
TYR B  86
TYR A  95
 None
 0.66A 2oldA-4jznB:
16.1
2oldB-4jznB:
21.5		 2oldA-4jznB:
46.64
2oldB-4jznB:
46.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4jzn ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN
(Homo
sapiens) 		4 / 8 THR B  73
TYR B  85
TRP B  34
ARG B  19
 None
 1.28A 3wipB-4jznB:
3.0
3wipC-4jznB:
3.0		 3wipB-4jznB:
23.63
3wipC-4jznB:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN
ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN
(Homo
sapiens) 		4 / 8 TYR A  95
TRP A 109
VAL B  44
VAL B  46
 None
 1.15A 4aftD-4jznA:
undetectable
4aftE-4jznA:
undetectable		 4aftD-4jznA:
22.51
4aftE-4jznA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN
ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TRP B  90
TRP A  47
THR A  35
 None
 1.42A 4bboB-4jznB:
undetectable		 4bboB-4jznB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 4jzn ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 ASP B 169
THR B 171
TYR B 139
THR B 108
 None
 1.31A 5b6iA-4jznB:
undetectable		 5b6iA-4jznB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 4jzn ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN
(Homo
sapiens) 		4 / 6 ASP B 169
THR B 171
TYR B 139
THR B 108
 None
 1.30A 5b6iB-4jznB:
undetectable		 5b6iB-4jznB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4jzn ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 ASP B  52
TRP B  34
HIS B  33
TYR B  85
 None
 1.45A 5ov9B-4jznB:
undetectable		 5ov9B-4jznB:
16.67