SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4jzt DGTP
PYROPHOSPHOHYDROLASE
(Bacillus
subtilis) 		4 / 6 LEU A 121
LEU A 107
PRO A  51
VAL A  69
 None
 0.82A 2dqyC-4jztA:
undetectable		 2dqyC-4jztA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4jzt DGTP
PYROPHOSPHOHYDROLASE
(Bacillus
subtilis) 		5 / 11 MET A 139
LEU A 125
LEU A 148
SER A 147
LEU A  83
 None
 1.28A 2po5B-4jztA:
undetectable		 2po5B-4jztA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4jzt DGTP
PYROPHOSPHOHYDROLASE
(Bacillus
subtilis) 		3 / 3 LEU A  14
TYR A  86
GLN A  85
 None
GTP  A 201 (-4.8A)
None
 0.75A 2wekA-4jztA:
undetectable		 2wekA-4jztA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4jzt DGTP
PYROPHOSPHOHYDROLASE
(Bacillus
subtilis) 		4 / 4 ALA A  61
ALA A  64
ALA A  65
ALA A  68
 None
 0.11A 4oaeA-4jztA:
undetectable		 4oaeA-4jztA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4jzt DGTP
PYROPHOSPHOHYDROLASE
(Bacillus
subtilis) 		5 / 12 ILE A  31
PHE A  50
ILE A 157
LEU A 129
LEU A 125
 None
 1.25A 5jkvA-4jztA:
undetectable		 5jkvA-4jztA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 4jzt DGTP
PYROPHOSPHOHYDROLASE
(Bacillus
subtilis) 		3 / 3 GLU A  63
LEU A  66
ARG A  76
 None
 0.66A 6d8fA-4jztA:
undetectable		 6d8fA-4jztA:
13.07