SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 7 LEU A 318
THR A 313
LEU A 311
LEU A 277
 None
 0.81A 1gtiA-4jzxA:
undetectable		 1gtiA-4jzxA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.72A 1rqjA-4jzxA:
31.0		 1rqjA-4jzxA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.46A 1rqjA-4jzxA:
31.0		 1rqjA-4jzxA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.74A 1rqjB-4jzxA:
31.0		 1rqjB-4jzxA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.45A 1rqjB-4jzxA:
31.0		 1rqjB-4jzxA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 7 MET A 101
ASP A 102
ASP A  99
LYS A 264
 None
CA  A 403 (-2.5A)
None
476  A 402 (-2.9A)
 1.31A 1t03A-4jzxA:
undetectable		 1t03A-4jzxA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.13A 1yhlA-4jzxA:
54.0		 1yhlA-4jzxA:
63.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.63A 1yhlA-4jzxA:
54.0		 1yhlA-4jzxA:
63.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.44A 1yhlA-4jzxA:
54.0		 1yhlA-4jzxA:
63.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 LEU A  95
ARG A 107
THR A 212
TYR A 211
LYS A 264
 None
476  A 402 (-2.9A)
IPE  A 401 ( 4.6A)
None
476  A 402 (-2.9A)
 1.45A 1yq7A-4jzxA:
43.7		 1yq7A-4jzxA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.71A 1yq7A-4jzxA:
43.7		 1yq7A-4jzxA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.53A 1yq7A-4jzxA:
43.7		 1yq7A-4jzxA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.59A 1yv5A-4jzxA:
44.0		 1yv5A-4jzxA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.37A 1yv5A-4jzxA:
44.0		 1yv5A-4jzxA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.60A 1zw5A-4jzxA:
45.1		 1zw5A-4jzxA:
38.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.42A 1zw5A-4jzxA:
45.1		 1zw5A-4jzxA:
38.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 0.70A 2e91A-4jzxA:
24.5		 2e91A-4jzxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
THR A 163
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-4.8A)
 1.38A 2e91A-4jzxA:
24.5		 2e91A-4jzxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 0.52A 2e91A-4jzxA:
24.5		 2e91A-4jzxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 0.66A 2e91B-4jzxA:
23.7		 2e91B-4jzxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
THR A 163
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-4.8A)
 1.45A 2e91B-4jzxA:
23.7		 2e91B-4jzxA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.07A 2f89F-4jzxA:
46.2		 2f89F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.29A 2f89F-4jzxA:
46.2		 2f89F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.15A 2f8cF-4jzxA:
45.1		 2f8cF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 LEU A  95
ARG A 107
THR A 212
TYR A 211
LYS A 264
 None
476  A 402 (-2.9A)
IPE  A 401 ( 4.6A)
None
476  A 402 (-2.9A)
 1.42A 2f8cF-4jzxA:
45.1		 2f8cF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.59A 2f8cF-4jzxA:
45.1		 2f8cF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.38A 2f8cF-4jzxA:
45.1		 2f8cF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.16A 2f8zF-4jzxA:
45.8		 2f8zF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.60A 2f8zF-4jzxA:
45.8		 2f8zF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		12 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.37A 2f94F-4jzxA:
44.8		 2f94F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.16A 2f9kF-4jzxA:
44.9		 2f9kF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.63A 2f9kF-4jzxA:
44.9		 2f9kF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.42A 2f9kF-4jzxA:
44.9		 2f9kF-4jzxA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 6 LEU A 131
VAL A 218
MET A 219
ILE A  87
 None
 1.15A 2hyyC-4jzxA:
undetectable		 2hyyC-4jzxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
 0.76A 2o1oA-4jzxA:
37.2		 2o1oA-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
 0.53A 2o1oA-4jzxA:
37.2		 2o1oA-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 LEU A  95
ASP A  98
ASP A 102
GLN A 167
THR A 163
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-3.5A)
476  A 402 (-4.8A)
 1.48A 2o1oA-4jzxA:
37.2		 2o1oA-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.75A 2o1oB-4jzxA:
37.7		 2o1oB-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
 0.64A 2o1oB-4jzxA:
37.7		 2o1oB-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ASP A 102
GLN A 167
GLN A 247
ASP A 251
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
None
 0.84A 2q58A-4jzxA:
36.9		 2q58A-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ASP A 102
LYS A 207
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 1.48A 2q58A-4jzxA:
36.9		 2q58A-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 251
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
None
 0.82A 2q58A-4jzxA:
36.9		 2q58A-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.79A 2q58B-4jzxA:
37.1		 2q58B-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
 0.65A 2q58B-4jzxA:
37.1		 2q58B-4jzxA:
25.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.14A 2qisA-4jzxA:
44.5		 2qisA-4jzxA:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.62A 2qisA-4jzxA:
44.5		 2qisA-4jzxA:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 7 SER A 173
TYR A 195
VAL A 279
ILE A 203
 None
 1.26A 2x45B-4jzxA:
undetectable		 2x45B-4jzxA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 7 SER A 173
TYR A 195
VAL A 279
ILE A 203
 None
 1.24A 2x45C-4jzxA:
undetectable		 2x45C-4jzxA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 7 SER A 173
TYR A 195
VAL A 279
ILE A 203
 None
 1.22A 3bu1A-4jzxA:
undetectable		 3bu1A-4jzxA:
15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.08A 3ez3A-4jzxA:
44.6		 3ez3A-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.83A 3ez3A-4jzxA:
44.6		 3ez3A-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.60A 3ez3A-4jzxA:
44.6		 3ez3A-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.06A 3ez3B-4jzxA:
44.0		 3ez3B-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.71A 3ez3B-4jzxA:
44.0		 3ez3B-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.49A 3ez3B-4jzxA:
44.0		 3ez3B-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.05A 3ez3C-4jzxA:
44.6		 3ez3C-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.74A 3ez3C-4jzxA:
44.6		 3ez3C-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.62A 3ez3C-4jzxA:
44.6		 3ez3C-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.13A 3ez3D-4jzxA:
43.7		 3ez3D-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.72A 3ez3D-4jzxA:
43.7		 3ez3D-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.46A 3ez3D-4jzxA:
43.7		 3ez3D-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 10 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.74A 3ibaA-4jzxA:
53.8		 3ibaA-4jzxA:
63.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.50A 3ibaA-4jzxA:
53.8		 3ibaA-4jzxA:
63.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 6 SER A  38
ASP A 127
TYR A  35
PRO A 117
 None
 1.41A 3jqaA-4jzxA:
undetectable		 3jqaA-4jzxA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.05A 3ldwA-4jzxA:
44.6		 3ldwA-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.86A 3ldwA-4jzxA:
44.6		 3ldwA-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.62A 3ldwA-4jzxA:
44.6		 3ldwA-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.12A 3ldwB-4jzxA:
44.0		 3ldwB-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.73A 3ldwB-4jzxA:
44.0		 3ldwB-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.51A 3ldwB-4jzxA:
44.0		 3ldwB-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.83A 3ldwC-4jzxA:
44.5		 3ldwC-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.60A 3ldwC-4jzxA:
44.5		 3ldwC-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.14A 3ldwD-4jzxA:
43.7		 3ldwD-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.72A 3ldwD-4jzxA:
43.7		 3ldwD-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.50A 3ldwD-4jzxA:
43.7		 3ldwD-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.12A 3n45F-4jzxA:
45.1		 3n45F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 LEU A  95
ARG A 107
THR A 212
TYR A 211
LYS A 264
 None
476  A 402 (-2.9A)
IPE  A 401 ( 4.6A)
None
476  A 402 (-2.9A)
 1.48A 3n45F-4jzxA:
45.1		 3n45F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.64A 3n45F-4jzxA:
45.1		 3n45F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.42A 3n45F-4jzxA:
45.1		 3n45F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.14A 3n46F-4jzxA:
44.8		 3n46F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.64A 3n46F-4jzxA:
44.8		 3n46F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.40A 3n46F-4jzxA:
44.8		 3n46F-4jzxA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		3 / 3 LYS A 264
ARG A  51
LEU A  95
 476  A 402 (-2.9A)
IPE  A 401 (-2.8A)
None
 1.42A 3v4tE-4jzxA:
undetectable		 3v4tE-4jzxA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.11A 4kfaA-4jzxA:
43.9		 4kfaA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.66A 4kfaA-4jzxA:
43.9		 4kfaA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.12A 4kpdA-4jzxA:
45.3		 4kpdA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.63A 4kpdA-4jzxA:
45.3		 4kpdA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.37A 4kpdA-4jzxA:
45.3		 4kpdA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.12A 4kpjA-4jzxA:
43.9		 4kpjA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.43A 4kpjA-4jzxA:
43.9		 4kpjA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.11A 4kq5A-4jzxA:
44.3		 4kq5A-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.68A 4kq5A-4jzxA:
44.3		 4kq5A-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.47A 4kq5A-4jzxA:
44.3		 4kq5A-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.12A 4kqsA-4jzxA:
45.0		 4kqsA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.62A 4kqsA-4jzxA:
45.0		 4kqsA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.40A 4kqsA-4jzxA:
45.0		 4kqsA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.11A 4n9uA-4jzxA:
44.1		 4n9uA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.63A 4n9uA-4jzxA:
44.1		 4n9uA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.46A 4n9uA-4jzxA:
44.1		 4n9uA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 208
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 ( 3.4A)
 1.34A 4n9uA-4jzxA:
44.1		 4n9uA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 12 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.11A 4ng6A-4jzxA:
45.3		 4ng6A-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		11 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-3.5A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.41A 4ng6A-4jzxA:
45.3		 4ng6A-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.74A 4nkeA-4jzxA:
44.2		 4nkeA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.60A 4nkeA-4jzxA:
44.2		 4nkeA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 LEU A  95
ASP A  98
ASP A 102
GLN A 167
THR A 163
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-3.5A)
476  A 402 (-4.8A)
 1.49A 4nkeA-4jzxA:
44.2		 4nkeA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.09A 4nkfA-4jzxA:
44.2		 4nkfA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.47A 4nkfA-4jzxA:
44.2		 4nkfA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.31A 4nuaA-4jzxA:
44.3		 4nuaA-4jzxA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.79A 4nuaA-4jzxA:
44.3		 4nuaA-4jzxA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.66A 4nuaA-4jzxA:
44.3		 4nuaA-4jzxA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.09A 4oguA-4jzxA:
44.1		 4oguA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.40A 4oguA-4jzxA:
44.1		 4oguA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.14A 4p0vA-4jzxA:
45.6		 4p0vA-4jzxA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.63A 4p0vA-4jzxA:
45.6		 4p0vA-4jzxA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.45A 4p0vA-4jzxA:
45.6		 4p0vA-4jzxA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.10A 4p0wA-4jzxA:
45.6		 4p0wA-4jzxA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 LEU A  95
ARG A 107
THR A 212
TYR A 211
LYS A 264
 None
476  A 402 (-2.9A)
IPE  A 401 ( 4.6A)
None
476  A 402 (-2.9A)
 1.47A 4p0wA-4jzxA:
45.6		 4p0wA-4jzxA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.62A 4p0wA-4jzxA:
45.6		 4p0wA-4jzxA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.43A 4p0wA-4jzxA:
45.6		 4p0wA-4jzxA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.63A 4q23A-4jzxA:
44.1		 4q23A-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.37A 4q23A-4jzxA:
44.1		 4q23A-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.67A 4rxdA-4jzxA:
54.0		 4rxdA-4jzxA:
58.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.45A 4rxdA-4jzxA:
54.0		 4rxdA-4jzxA:
58.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.66A 4rxdB-4jzxA:
54.4		 4rxdB-4jzxA:
58.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.45A 4rxdB-4jzxA:
54.4		 4rxdB-4jzxA:
58.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.66A 4rxdC-4jzxA:
54.4		 4rxdC-4jzxA:
58.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.44A 4rxdC-4jzxA:
54.4		 4rxdC-4jzxA:
58.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 8 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
 0.50A 4umjA-4jzxA:
24.1		 4umjA-4jzxA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
 0.53A 4umjB-4jzxA:
24.2		 4umjB-4jzxA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
 1.14A 4umjB-4jzxA:
24.2		 4umjB-4jzxA:
27.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 12 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.18A 5cg5A-4jzxA:
44.4		 5cg5A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.66A 5cg5A-4jzxA:
44.4		 5cg5A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		11 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.43A 5cg5A-4jzxA:
44.4		 5cg5A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 12 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.12A 5cg6A-4jzxA:
45.2		 5cg6A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 12 PHE A  94
LEU A  95
ARG A 107
THR A 212
LYS A 264
 476  A 402 (-4.3A)
None
476  A 402 (-2.9A)
IPE  A 401 ( 4.6A)
476  A 402 (-2.9A)
 0.96A 5cg6A-4jzxA:
45.2		 5cg6A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		11 / 12 PHE A  94
LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 476  A 402 (-4.3A)
None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.67A 5cg6A-4jzxA:
45.2		 5cg6A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		11 / 12 PHE A  94
LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 476  A 402 (-4.3A)
None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.40A 5cg6A-4jzxA:
45.2		 5cg6A-4jzxA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 0.74A 5eroA-4jzxA:
26.9		 5eroA-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
ASP A 251
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
None
 0.78A 5eroB-4jzxA:
26.6		 5eroB-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ASP A 102
LYS A 207
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 1.44A 5eroB-4jzxA:
26.6		 5eroB-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 10 ASP A  98
ASP A  99
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
None
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 0.62A 5eroC-4jzxA:
26.7		 5eroC-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ASP A 102
LYS A 207
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 1.39A 5eroC-4jzxA:
26.7		 5eroC-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 10 ASP A  99
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
ASP A 251
 None
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
None
 0.72A 5eroC-4jzxA:
26.7		 5eroC-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A 102
ARG A 107
LYS A 207
ASP A 251
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
None
476  A 402 (-2.9A)
 1.27A 5eroC-4jzxA:
26.7		 5eroC-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A 102
ASP A  99
ARG A 107
ASP A 250
ASP A 251
 CA  A 403 (-2.5A)
None
476  A 402 (-2.9A)
CA  A 404 (-3.0A)
None
 1.48A 5eroC-4jzxA:
26.7		 5eroC-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 8 PHE A 321
THR A 208
GLN A 249
GLY A 243
 None
IPE  A 401 ( 3.4A)
None
None
 0.95A 5nzxA-4jzxA:
undetectable		 5nzxA-4jzxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 7 PHE A 321
THR A 208
GLN A 249
GLY A 243
 None
IPE  A 401 ( 3.4A)
None
None
 0.95A 5nzyA-4jzxA:
undetectable		 5nzyA-4jzxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 7 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
 1.04A 6g31A-4jzxA:
25.3		 6g31A-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 6 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.83A 6g31B-4jzxA:
25.2		 6g31B-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 5 ASP A  98
ASP A 102
ARG A 107
LYS A 207
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
 1.12A 6g31C-4jzxA:
25.6		 6g31C-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 5 ASP A  98
ASP A 102
GLN A 167
LYS A 207
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
 1.11A 6g31C-4jzxA:
25.6		 6g31C-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 7 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.67A 6g31D-4jzxA:
24.9		 6g31D-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 4 LEU A  95
ASP A  98
ASP A 102
ARG A 107
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
 0.45A 6g31E-4jzxA:
19.3		 6g31E-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 5 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.89A 6g31F-4jzxA:
25.4		 6g31F-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 7 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
 0.82A 6g31G-4jzxA:
24.3		 6g31G-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 5 ASP A  98
ASP A 102
GLN A 167
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.59A 6g31H-4jzxA:
24.3		 6g31H-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_I_ZOLI401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 4 ASP A  98
ASP A 102
LYS A 207
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
 0.96A 6g31I-4jzxA:
24.2		 6g31I-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 6 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 1.01A 6g31J-4jzxA:
25.7		 6g31J-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 4 ASP A  98
ASP A 102
ARG A 107
GLN A 167
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
 0.63A 6g31K-4jzxA:
23.3		 6g31K-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 6 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 1.07A 6g31L-4jzxA:
25.2		 6g31L-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 6 ASP A  98
GLN A 167
GLN A 247
LYS A 273
 CA  A 403 (-2.5A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 403 ( 4.9A)
 1.34A 6g31L-4jzxA:
25.2		 6g31L-4jzxA:
14.01