SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 1c9sJ-4jzyA:
undetectable
1c9sK-4jzyA:
undetectable		 1c9sJ-4jzyA:
9.28
1c9sK-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.36A 1gtfA-4jzyA:
undetectable
1gtfB-4jzyA:
undetectable		 1gtfA-4jzyA:
9.28
1gtfB-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 1gtfH-4jzyA:
undetectable
1gtfI-4jzyA:
undetectable		 1gtfH-4jzyA:
9.28
1gtfI-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 GLU A 111
HIS A 138
SER A 414
HIS A  13
TYR A 319
 None
 1.48A 1karA-4jzyA:
1.7
1karB-4jzyA:
1.7		 1karA-4jzyA:
23.30
1karB-4jzyA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		4 / 7 LEU A 287
ILE A 313
THR A 309
TRP A 141
 None
 1.16A 1kglA-4jzyA:
undetectable		 1kglA-4jzyA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 12 ASN A 505
ASP A 364
ILE A 496
ALA A 501
THR A 438
 None
 1.21A 1kijB-4jzyA:
undetectable		 1kijB-4jzyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 12 ILE A   9
ALA A  26
ALA A 183
LEU A  71
PHE A  11
 None
 1.14A 2h77A-4jzyA:
undetectable		 2h77A-4jzyA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 11 GLY A  44
SER A  46
THR A  49
GLY A  48
PHE A  59
 None
 1.45A 2hmaA-4jzyA:
3.4		 2hmaA-4jzyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		4 / 7 PHE A 272
PRO A 205
LEU A  61
PHE A  42
 None
NH4  A 602 ( 4.9A)
None
None
 1.01A 2vcvA-4jzyA:
undetectable		 2vcvA-4jzyA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		3 / 3 TRP A 420
GLN A 402
TRP A 394
 FAD  A 601 (-3.6A)
None
None
 1.02A 2vqyA-4jzyA:
undetectable		 2vqyA-4jzyA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		4 / 7 PHE A 161
ILE A 313
PRO A 143
TRP A 141
 None
 0.78A 2y7kA-4jzyA:
undetectable		 2y7kA-4jzyA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		3 / 3 GLN A 357
THR A 358
LEU A 370
 None
 0.66A 3ondA-4jzyA:
undetectable		 3ondA-4jzyA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		3 / 3 GLN A 357
THR A 358
LEU A 370
 None
 0.67A 3ondB-4jzyA:
undetectable		 3ondB-4jzyA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		4 / 8 LEU A 162
TYR A 158
PHE A 161
TYR A 281
 None
 1.15A 3po7A-4jzyA:
undetectable		 3po7A-4jzyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		4 / 5 LEU A 362
LEU A 443
THR A 379
TRP A 536
 None
 1.45A 4do3A-4jzyA:
undetectable		 4do3A-4jzyA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		3 / 3 ARG A  16
GLU A 107
ASN A  20
 None
 0.78A 4imaD-4jzyA:
undetectable		 4imaD-4jzyA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		3 / 3 ARG A  16
GLU A 107
ASN A  20
 None
 0.76A 4ip7D-4jzyA:
2.7		 4ip7D-4jzyA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 11 ILE A  67
LEU A 180
HIS A  18
ALA A 178
LEU A  23
 None
 0.95A 4p65E-4jzyA:
undetectable
4p65F-4jzyA:
undetectable
4p65J-4jzyA:
undetectable
4p65L-4jzyA:
undetectable		 4p65E-4jzyA:
4.71
4p65F-4jzyA:
6.74
4p65J-4jzyA:
6.74
4p65L-4jzyA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 12 LEU A  23
ILE A  67
LEU A 180
HIS A  18
ALA A 178
 None
 0.96A 4p65B-4jzyA:
undetectable
4p65D-4jzyA:
undetectable
4p65I-4jzyA:
undetectable
4p65J-4jzyA:
undetectable		 4p65B-4jzyA:
6.74
4p65D-4jzyA:
6.74
4p65I-4jzyA:
4.71
4p65J-4jzyA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 12 LEU A  23
ILE A  67
LEU A 180
HIS A  18
ALA A 178
 None
 0.99A 4p65F-4jzyA:
undetectable
4p65H-4jzyA:
undetectable
4p65K-4jzyA:
undetectable
4p65L-4jzyA:
undetectable		 4p65F-4jzyA:
6.74
4p65H-4jzyA:
6.74
4p65K-4jzyA:
4.71
4p65L-4jzyA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		4 / 5 VAL A  52
TYR A 457
ILE A 454
THR A 379
 None
 1.15A 4ze1A-4jzyA:
undetectable		 4ze1A-4jzyA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		3 / 3 ASP A 109
ARG A 278
ARG A  16
 None
 0.95A 5eajB-4jzyA:
undetectable		 5eajB-4jzyA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.35A 5eeuJ-4jzyA:
undetectable
5eeuK-4jzyA:
undetectable		 5eeuJ-4jzyA:
9.28
5eeuK-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.30A 5eeuT-4jzyA:
undetectable
5eeuU-4jzyA:
undetectable		 5eeuT-4jzyA:
9.28
5eeuU-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5eevH-4jzyA:
undetectable
5eevI-4jzyA:
undetectable		 5eevH-4jzyA:
9.28
5eevI-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5eevJ-4jzyA:
undetectable
5eevK-4jzyA:
undetectable		 5eevJ-4jzyA:
9.28
5eevK-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.31A 5eevT-4jzyA:
undetectable
5eevU-4jzyA:
undetectable		 5eevT-4jzyA:
9.28
5eevU-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5eewH-4jzyA:
undetectable
5eewI-4jzyA:
undetectable		 5eewH-4jzyA:
9.28
5eewI-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5eewJ-4jzyA:
undetectable
5eewK-4jzyA:
undetectable		 5eewJ-4jzyA:
9.28
5eewK-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.31A 5eewT-4jzyA:
undetectable
5eewU-4jzyA:
undetectable		 5eewT-4jzyA:
9.28
5eewU-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.33A 5eewU-4jzyA:
undetectable
5eewV-4jzyA:
undetectable		 5eewU-4jzyA:
9.28
5eewV-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5eexH-4jzyA:
undetectable
5eexI-4jzyA:
undetectable		 5eexH-4jzyA:
9.28
5eexI-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5eexJ-4jzyA:
undetectable
5eexK-4jzyA:
undetectable		 5eexJ-4jzyA:
9.28
5eexK-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.31A 5eexT-4jzyA:
undetectable
5eexU-4jzyA:
undetectable		 5eexT-4jzyA:
9.28
5eexU-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5eeyH-4jzyA:
undetectable
5eeyI-4jzyA:
undetectable		 5eeyH-4jzyA:
9.28
5eeyI-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5eeyJ-4jzyA:
undetectable
5eeyK-4jzyA:
undetectable		 5eeyJ-4jzyA:
9.28
5eeyK-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.31A 5eeyT-4jzyA:
undetectable
5eeyU-4jzyA:
undetectable		 5eeyT-4jzyA:
9.28
5eeyU-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.33A 5eeyU-4jzyA:
undetectable
5eeyV-4jzyA:
undetectable		 5eeyU-4jzyA:
9.28
5eeyV-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5eezH-4jzyA:
undetectable
5eezI-4jzyA:
undetectable		 5eezH-4jzyA:
9.28
5eezI-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5eezJ-4jzyA:
undetectable
5eezK-4jzyA:
undetectable		 5eezJ-4jzyA:
9.28
5eezK-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.31A 5eezT-4jzyA:
undetectable
5eezU-4jzyA:
undetectable		 5eezT-4jzyA:
9.28
5eezU-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.35A 5ef0C-4jzyA:
undetectable
5ef0D-4jzyA:
undetectable		 5ef0C-4jzyA:
9.28
5ef0D-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5ef0H-4jzyA:
undetectable
5ef0I-4jzyA:
undetectable		 5ef0H-4jzyA:
9.28
5ef0I-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5ef0J-4jzyA:
undetectable
5ef0K-4jzyA:
undetectable		 5ef0J-4jzyA:
9.28
5ef0K-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.31A 5ef0T-4jzyA:
undetectable
5ef0U-4jzyA:
undetectable		 5ef0T-4jzyA:
9.28
5ef0U-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.31A 5ef1B-4jzyA:
undetectable
5ef1C-4jzyA:
undetectable		 5ef1B-4jzyA:
9.28
5ef1C-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.35A 5ef1C-4jzyA:
undetectable
5ef1D-4jzyA:
undetectable		 5ef1C-4jzyA:
9.28
5ef1D-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5ef1H-4jzyA:
undetectable
5ef1I-4jzyA:
undetectable		 5ef1H-4jzyA:
9.28
5ef1I-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5ef1J-4jzyA:
undetectable
5ef1K-4jzyA:
undetectable		 5ef1J-4jzyA:
9.28
5ef1K-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.31A 5ef1T-4jzyA:
undetectable
5ef1U-4jzyA:
undetectable		 5ef1T-4jzyA:
9.28
5ef1U-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.33A 5ef1U-4jzyA:
undetectable
5ef1V-4jzyA:
undetectable		 5ef1U-4jzyA:
9.28
5ef1V-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.31A 5ef2B-4jzyA:
undetectable
5ef2C-4jzyA:
undetectable		 5ef2B-4jzyA:
9.28
5ef2C-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.35A 5ef2C-4jzyA:
undetectable
5ef2D-4jzyA:
undetectable		 5ef2C-4jzyA:
9.28
5ef2D-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.33A 5ef2J-4jzyA:
undetectable
5ef2K-4jzyA:
undetectable		 5ef2J-4jzyA:
9.28
5ef2K-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.31A 5ef2T-4jzyA:
undetectable
5ef2U-4jzyA:
undetectable		 5ef2T-4jzyA:
9.28
5ef2U-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.32A 5ef2U-4jzyA:
undetectable
5ef2V-4jzyA:
undetectable		 5ef2U-4jzyA:
9.28
5ef2V-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.31A 5ef3B-4jzyA:
undetectable
5ef3C-4jzyA:
undetectable		 5ef3B-4jzyA:
9.28
5ef3C-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.35A 5ef3C-4jzyA:
undetectable
5ef3D-4jzyA:
undetectable		 5ef3C-4jzyA:
9.28
5ef3D-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.34A 5ef3H-4jzyA:
undetectable
5ef3I-4jzyA:
undetectable		 5ef3H-4jzyA:
9.28
5ef3I-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 9 THR A 175
SER A 137
ALA A  22
HIS A  18
ILE A   9
 None
 1.33A 5ef3J-4jzyA:
undetectable
5ef3K-4jzyA:
undetectable		 5ef3J-4jzyA:
9.28
5ef3K-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.33A 5ef3A-4jzyA:
undetectable
5ef3K-4jzyA:
undetectable		 5ef3A-4jzyA:
9.28
5ef3K-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.31A 5ef3T-4jzyA:
undetectable
5ef3U-4jzyA:
undetectable		 5ef3T-4jzyA:
9.28
5ef3U-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ALA A  22
HIS A  18
ILE A   9
THR A 175
SER A 137
 None
 1.32A 5ef3U-4jzyA:
undetectable
5ef3V-4jzyA:
undetectable		 5ef3U-4jzyA:
9.28
5ef3V-4jzyA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		4 / 5 ALA A 178
PRO A 174
GLY A 310
LEU A 234
 None
 0.97A 5eslA-4jzyA:
undetectable		 5eslA-4jzyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		3 / 3 MET A 215
HIS A 403
GLY A 356
 None
 0.88A 5gwzB-4jzyA:
undetectable		 5gwzB-4jzyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		3 / 3 HIS A 138
ASP A 109
HIS A  13
 None
 0.69A 5n1tW-4jzyA:
undetectable		 5n1tW-4jzyA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ARG A  56
ALA A 411
LEU A 408
GLY A 374
LEU A 432
 None
FAD  A 601 (-4.6A)
None
None
None
 1.12A 5oy01-4jzyA:
undetectable
5oy07-4jzyA:
undetectable		 5oy01-4jzyA:
10.02
5oy07-4jzyA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		4 / 7 ILE A  91
LEU A  95
ILE A 106
ALA A   6
 None
 0.84A 6b5vA-4jzyA:
undetectable
6b5vC-4jzyA:
undetectable		 6b5vA-4jzyA:
10.25
6b5vC-4jzyA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		4 / 7 ILE A  91
LEU A  95
ILE A 106
ALA A   6
 None
 0.85A 6b5vC-4jzyA:
undetectable
6b5vD-4jzyA:
0.4		 6b5vC-4jzyA:
10.25
6b5vD-4jzyA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		4 / 7 ALA A   6
ILE A  91
LEU A  95
ILE A 106
 None
 0.84A 6b5vB-4jzyA:
undetectable
6b5vD-4jzyA:
0.4		 6b5vB-4jzyA:
10.25
6b5vD-4jzyA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		4 / 4 ILE A  67
LEU A 180
HIS A  18
ALA A 178
 None
 0.98A 6ck2C-4jzyA:
undetectable
6ck2D-4jzyA:
undetectable		 6ck2C-4jzyA:
4.71
6ck2D-4jzyA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		5 / 10 ARG A  56
ALA A 411
LEU A 408
GLY A 374
LEU A 432
 None
FAD  A 601 (-4.6A)
None
None
None
 1.14A 6hqbA-4jzyA:
undetectable
6hqbJ-4jzyA:
undetectable		 6hqbA-4jzyA:
9.21
6hqbJ-4jzyA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4jzy CRYPTOCHROME-1
(Drosophila
melanogaster) 		4 / 6 LEU A  64
PRO A 203
HIS A 207
GLU A  85
 None
 0.88A 6pahA-4jzyA:
undetectable		 6pahA-4jzyA:
21.62