SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 12 PRO A 204
GLY A 271
ILE A 154
LEU A 214
LEU A 206
 None
 1.16A 1r30A-4k05A:
undetectable		 1r30A-4k05A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 12 PRO A 204
GLY A 271
ILE A 154
LEU A 214
LEU A 206
 None
 1.16A 1r30B-4k05A:
undetectable		 1r30B-4k05A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		4 / 4 LEU A  60
SER A  73
LEU A 116
LEU A  86
 None
 1.09A 1yajA-4k05A:
undetectable		 1yajA-4k05A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		4 / 5 LEU A  60
SER A  73
LEU A 116
LEU A  86
 None
 1.16A 1yajD-4k05A:
undetectable		 1yajD-4k05A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 12 PHE A 377
ALA A 372
THR A 360
ALA A 367
ASP A 370
 None
 1.35A 2qm9A-4k05A:
undetectable		 2qm9A-4k05A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 12 ALA A 264
ARG A 149
PHE A 151
THR A  65
ILE A 143
 None
 0.99A 2w3bA-4k05A:
undetectable		 2w3bA-4k05A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		4 / 8 TYR A 119
TYR A  90
ALA A 160
ALA A 163
 None
 0.88A 2wx2B-4k05A:
undetectable		 2wx2B-4k05A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		4 / 6 ILE A 281
GLN A 352
GLU A 275
TYR A 205
 None
 1.14A 2ya7C-4k05A:
undetectable		 2ya7C-4k05A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		4 / 7 TYR A 278
ASN A 397
ASP A 370
SER A 394
 None
 1.30A 3lslA-4k05A:
undetectable
3lslD-4k05A:
undetectable		 3lslA-4k05A:
21.38
3lslD-4k05A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		4 / 8 ILE A 180
PRO A 179
GLY A 147
SER A 254
 None
 0.95A 3lslA-4k05A:
undetectable
3lslD-4k05A:
undetectable		 3lslA-4k05A:
21.38
3lslD-4k05A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		4 / 8 SER A 254
ILE A 180
PRO A 179
GLY A 147
 None
 0.91A 3lslA-4k05A:
undetectable
3lslD-4k05A:
undetectable		 3lslA-4k05A:
21.38
3lslD-4k05A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 12 VAL A 368
ILE A 281
LEU A 273
VAL A 297
ALA A 294
 None
 1.40A 4m11C-4k05A:
undetectable		 4m11C-4k05A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 12 VAL A 368
ILE A 281
LEU A 273
VAL A 297
ALA A 294
 None
 1.37A 4m11D-4k05A:
undetectable		 4m11D-4k05A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 12 PRO A 117
VAL A 118
SER A 113
SER A 112
GLY A 115
 None
 1.08A 4mmdB-4k05A:
undetectable		 4mmdB-4k05A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		4 / 8 SER A 255
HIS A  94
TYR A 267
GLU A  93
 None
 1.36A 4ms4A-4k05A:
4.4		 4ms4A-4k05A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		4 / 5 ILE A 203
PHE A 265
SER A 199
ASP A 145
 None
 1.06A 4rzvB-4k05A:
undetectable		 4rzvB-4k05A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 11 LEU A 276
PHE A 369
ASP A 370
ALA A 372
THR A 360
 None
 1.19A 4uuuB-4k05A:
undetectable		 4uuuB-4k05A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		4 / 7 LEU A 133
PRO A 128
ILE A  61
LEU A  60
 None
 0.86A 5fxtA-4k05A:
undetectable		 5fxtA-4k05A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		4 / 7 ILE A  72
HIS A  79
LEU A  78
ALA A  81
 None
None
None
K  A 501 (-4.7A)
 0.94A 5hrqE-4k05A:
undetectable
5hrqF-4k05A:
undetectable
5hrqJ-4k05A:
undetectable		 5hrqE-4k05A:
7.84
5hrqF-4k05A:
9.86
5hrqJ-4k05A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 12 LEU A  71
ILE A 252
ARG A 176
ASP A 142
LEU A  60
 None
 1.48A 5nn8A-4k05A:
undetectable		 5nn8A-4k05A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		4 / 7 LEU A 311
TRP A 399
TYR A 407
GLU A 186
 None
 1.25A 5umwA-4k05A:
undetectable
5umwF-4k05A:
undetectable		 5umwA-4k05A:
10.83
5umwF-4k05A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 12 ILE A 185
LEU A 348
LEU A 183
GLY A 182
ASN A 178
 None
 1.05A 6r2eA-4k05A:
undetectable		 6r2eA-4k05A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 10 ILE A 185
LEU A 348
LEU A 183
GLY A 182
ASN A 178
 None
 1.00A 6r2eB-4k05A:
undetectable		 6r2eB-4k05A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 10 ILE A 185
LEU A 348
LEU A 183
GLY A 182
ASN A 178
 None
 1.04A 6r2eC-4k05A:
undetectable		 6r2eC-4k05A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 10 ILE A 185
LEU A 348
LEU A 183
GLY A 182
ASN A 178
 None
 1.01A 6r2eD-4k05A:
undetectable		 6r2eD-4k05A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 12 ILE A 185
LEU A 348
LEU A 183
GLY A 182
ASN A 178
 None
 1.02A 6r2eE-4k05A:
undetectable		 6r2eE-4k05A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 11 ILE A 185
LEU A 348
LEU A 183
GLY A 182
ASN A 178
 None
 1.03A 6r2eF-4k05A:
undetectable		 6r2eF-4k05A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 11 ILE A 185
LEU A 348
LEU A 183
GLY A 182
ASN A 178
 None
 1.02A 6r2eG-4k05A:
undetectable		 6r2eG-4k05A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN
(Bacteroides
fragilis) 		5 / 12 ILE A 185
LEU A 348
LEU A 183
GLY A 182
ASN A 178
 None
 1.18A 6r2eH-4k05A:
undetectable		 6r2eH-4k05A:
22.22