SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k0d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4k0d PERIPLASMIC SENSOR
HYBRID HISTIDINE
KINASE
(Anaeromyxobacter
dehalogenans) 		5 / 12 PHE A 162
GLY A 107
ALA A 108
SER A 111
LEU A 115
 None
 1.09A 1igxA-4k0dA:
undetectable		 1igxA-4k0dA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4k0d PERIPLASMIC SENSOR
HYBRID HISTIDINE
KINASE
(Anaeromyxobacter
dehalogenans) 		4 / 6 PHE A  98
ALA A  99
LEU A 101
SER A 111
 None
 1.04A 1sbrA-4k0dA:
undetectable
1sbrB-4k0dA:
undetectable		 1sbrA-4k0dA:
23.58
1sbrB-4k0dA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k0d PERIPLASMIC SENSOR
HYBRID HISTIDINE
KINASE
(Anaeromyxobacter
dehalogenans) 		5 / 12 PHE A 162
GLY A 107
ALA A 108
SER A 111
LEU A 115
 None
 0.99A 3hs6B-4k0dA:
undetectable		 3hs6B-4k0dA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4k0d PERIPLASMIC SENSOR
HYBRID HISTIDINE
KINASE
(Anaeromyxobacter
dehalogenans) 		3 / 3 THR A 147
ALA A 124
LYS A 123
 None
 0.76A 6fgcA-4k0dA:
undetectable		 6fgcA-4k0dA:
15.50