SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQH_A_FLPA701_1 (PROSTAGLANDIN H2 SYNTHASE-1)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	VAL A 993 ILE A 392 GLY A 390 ALA A 391 LEU A 989	None	0.93A	1eqhA-4k0eA: undetectable	1eqhA-4k0eA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQH_B_FLPB1701_1 (PROSTAGLANDIN H2 SYNTHASE-1)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	VAL A 993 ILE A 392 GLY A 390 ALA A 391 LEU A 989	None	0.93A	1eqhB-4k0eA: undetectable	1eqhB-4k0eA: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1J8U_A_H4BA429_1 (PHENYLALANINE-4-HYDR OXYLASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 7	LEU A 344 SER A 346 LEU A 349 ALA A 363	None	0.87A	1j8uA-4k0eA: undetectable	1j8uA-4k0eA: 15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JG4_A_SAMA500_0 (PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	GLN A 281 VAL A 594 GLY A 272 THR A 611 ALA A 612	None	1.07A	1jg4A-4k0eA: undetectable	1jg4A-4k0eA: 12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_B_THAB2_1 (LIVER CARBOXYLESTERASE I)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 11	LEU A 338 GLY A 390 VAL A 915 LEU A 972 LEU A 989	None	1.11A	1mx1B-4k0eA: 2.4	1mx1B-4k0eA: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_C_THAC3_1 (LIVER CARBOXYLESTERASE I)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	LEU A 338 GLY A 390 VAL A 915 LEU A 972 LEU A 989	None	1.09A	1mx1C-4k0eA: 2.5	1mx1C-4k0eA: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_E_THAE5_1 (LIVER CARBOXYLESTERASE I)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	LEU A 338 GLY A 390 VAL A 915 LEU A 972 LEU A 989	None	1.13A	1mx1E-4k0eA: 2.4	1mx1E-4k0eA: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ONI_A_BEZA501_0 (14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 7	PHE A 451 ALA A 465 TYR A 458 ILE A 382	None	1.11A	1oniA-4k0eA: undetectable 1oniB-4k0eA: undetectable	1oniA-4k0eA: 9.30 1oniB-4k0eA: 9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ONI_I_BEZI517_0 (14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 7	TYR A 458 ILE A 382 PHE A 451 ALA A 465	None	1.06A	1oniG-4k0eA: undetectable 1oniI-4k0eA: undetectable	1oniG-4k0eA: 9.30 1oniI-4k0eA: 9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R9O_A_FLPA501_1 (CYTOCHROME P450 2C9)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	6 / 12	ILE A 397 VAL A 923 GLY A 400 ALA A 401 THR A 365 LEU A 349	None	1.47A	1r9oA-4k0eA: undetectable	1r9oA-4k0eA: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S9P_A_DESA459_1 (ESTROGEN-RELATED RECEPTOR GAMMA)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	LEU A 481 LEU A 477 ALA A 475 MET A 440 LEU A 472	None	1.13A	1s9pA-4k0eA: undetectable	1s9pA-4k0eA: 13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W0G_A_MYTA1499_1 (CYTOCHROME P450 3A4)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 6	ILE A 929 ALA A 928 THR A1004 ALA A 894	None	0.95A	1w0gA-4k0eA: 0.7	1w0gA-4k0eA: 18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CL5_B_SAMB1217_1 (CATECHOL O-METHYLTRANSFERASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 6	GLU A 552 TYR A 39 GLN A 628 ASP A 654	None	1.31A	2cl5B-4k0eA: undetectable	2cl5B-4k0eA: 12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GLU_B_SAMB302_0 (YCGJ)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	GLY A 898 GLY A 995 ALA A 894 ARG A 905 PHE A 917	None	1.00A	2gluB-4k0eA: undetectable	2gluB-4k0eA: 12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2KCE_A_D16A566_1 (THYMIDYLATE SYNTHASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	LEU A 482 GLY A 474 PHE A 473 VAL A 23 ALA A 24	None	1.26A	2kceA-4k0eA: undetectable	2kceA-4k0eA: 13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PNJ_A_CHDA501_0 (FERROCHELATASE, MITOCHONDRIAL)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	LEU A 823 PHE A 822 LEU A 819 ILE A 830 LEU A 660	None	0.99A	2pnjA-4k0eA: undetectable	2pnjA-4k0eA: 15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO5_A_CHDA501_0 (FERROCHELATASE, MITOCHONDRIAL)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	LEU A 823 PHE A 822 LEU A 819 ILE A 830 LEU A 660	None	0.89A	2po5A-4k0eA: undetectable	2po5A-4k0eA: 15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO7_A_CHDA501_0 (FERROCHELATASE, MITOCHONDRIAL)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	LEU A 823 PHE A 822 LEU A 819 ILE A 830 LEU A 660	None	0.96A	2po7A-4k0eA: undetectable	2po7A-4k0eA: 15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO7_B_CHDB501_0 (FERROCHELATASE, MITOCHONDRIAL)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	LEU A 823 PHE A 822 LEU A 819 ILE A 830 LEU A 660	None	0.99A	2po7B-4k0eA: undetectable	2po7B-4k0eA: 15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_B_KLNB1498_1 (CYTOCHROME P450 3A4)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 9	ILE A 321 ALA A 612 GLU A 599 GLY A 177 LEU A 271	None None ZN A1102 ( 4.9A) None None	1.25A	2v0mB-4k0eA: undetectable	2v0mB-4k0eA: 18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X9G_A_LYAA1270_2 (PTERIDINE REDUCTASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	3 / 3	MET A 573 VAL A 613 GLU A 583	None	0.90A	2x9gA-4k0eA: undetectable	2x9gA-4k0eA: 14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZJ0_D_2FAD500_2 (ADENOSYLHOMOCYSTEINA SE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 4	LEU A 808 GLN A 681 THR A 679 THR A 797	None	1.50A	2zj0D-4k0eA: undetectable	2zj0D-4k0eA: 20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZVJ_A_SAMA301_1 (CATECHOL O-METHYLTRANSFERASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 6	GLU A 552 TYR A 39 GLN A 628 ASP A 654	None	1.34A	2zvjA-4k0eA: undetectable	2zvjA-4k0eA: 12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A7E_A_SAMA216_1 (CATECHOL O-METHYLTRANSFERASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 6	GLY A 655 ILE A 653 ILE A 42 ASP A 658	None	0.93A	3a7eA-4k0eA: undetectable	3a7eA-4k0eA: 12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AVP_A_MV2A313_1 (PANTOTHENATE KINASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 7	ASP A 393 LEU A 997 ILE A 930 ASN A 927	None	1.00A	3avpA-4k0eA: undetectable	3avpA-4k0eA: 15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B9L_A_AZZA1009_1 (SERUM ALBUMIN)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 8	GLU A 704 SER A 605 HIS A 664 ARG A 811	None	0.93A	3b9lA-4k0eA: 3.3	3b9lA-4k0eA: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BEX_F_PAUF248_0 (TYPE III PANTOTHENATE KINASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 11	LEU A 561 GLY A 571 ASP A 575 THR A 592 ILE A 609	None	1.28A	3bexE-4k0eA: undetectable 3bexF-4k0eA: undetectable	3bexE-4k0eA: 13.57 3bexF-4k0eA: 13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BF1_C_PAUC248_0 (TYPE III PANTOTHENATE KINASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 11	GLY A 571 THR A 592 ILE A 609 THR A 644 LEU A 561	None	1.42A	3bf1C-4k0eA: undetectable 3bf1D-4k0eA: undetectable	3bf1C-4k0eA: 13.57 3bf1D-4k0eA: 13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BF1_D_PAUD248_0 (TYPE III PANTOTHENATE KINASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 11	LEU A 561 GLY A 571 ASP A 575 THR A 592 ILE A 609	None	1.27A	3bf1C-4k0eA: undetectable 3bf1D-4k0eA: undetectable	3bf1C-4k0eA: 13.57 3bf1D-4k0eA: 13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BXO_A_SAMA238_1 (N,N-DIMETHYLTRANSFER ASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	3 / 3	TYR A 140 GLU A 136 ASP A 658	None	0.81A	3bxoA-4k0eA: undetectable	3bxoA-4k0eA: 13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BXO_B_SAMB238_1 (N,N-DIMETHYLTRANSFER ASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	3 / 3	TYR A 140 GLU A 136 ASP A 658	None	0.77A	3bxoB-4k0eA: undetectable	3bxoB-4k0eA: 13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CL9_A_MTXA602_2 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (DHFR-TS))	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 4	VAL A 559 ARG A 637 ILE A 631 THR A 592	None	1.23A	3cl9A-4k0eA: undetectable	3cl9A-4k0eA: 19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CLD_B_GW6B2_2 (GLUCOCORTICOID RECEPTOR)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 8	MET A 573 ALA A 574 LEU A 577 GLN A 558	None	0.94A	3cldB-4k0eA: undetectable	3cldB-4k0eA: 12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_C_TRPC1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 9	GLY A 739 GLN A 182 VAL A 755 ILE A 737 GLN A 266	None	1.45A	3fi0C-4k0eA: undetectable	3fi0C-4k0eA: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_F_TRPF1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 9	GLY A 739 GLN A 182 VAL A 755 ILE A 737 GLN A 266	None	1.37A	3fi0F-4k0eA: undetectable	3fi0F-4k0eA: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FI0_J_TRPJ1001_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 9	GLY A 739 GLN A 182 VAL A 755 ILE A 737 GLN A 266	None	1.33A	3fi0J-4k0eA: undetectable	3fi0J-4k0eA: 15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GLQ_A_RABA602_2 (ADENOSYLHOMOCYSTEINA SE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 5	GLN A 681 THR A 679 GLU A 796 THR A 797	None	1.41A	3glqA-4k0eA: undetectable	3glqA-4k0eA: 20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCO_A_CHDA3_0 (FERROCHELATASE, MITOCHONDRIAL)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 4	LEU A 517 PRO A1009 LEU A 514 ARG A 509	None	1.24A	3hcoA-4k0eA: undetectable	3hcoA-4k0eA: 16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_A_08JA1_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 8	VAL A 50 LEU A 92 LEU A 90 ASN A 597	None	0.87A	3u5kA-4k0eA: undetectable	3u5kA-4k0eA: 7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_B_08JB2_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 7	VAL A 50 LEU A 92 LEU A 90 ASN A 597	None	0.97A	3u5kB-4k0eA: undetectable	3u5kB-4k0eA: 7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_C_08JC3_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 8	VAL A 50 LEU A 92 LEU A 90 ASN A 597	None	0.87A	3u5kC-4k0eA: undetectable	3u5kC-4k0eA: 7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_A_CHDA1507_0 (FERROCHELATASE, MITOCHONDRIAL)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	3 / 3	ARG A 423 LYS A 423 ARG A 412	None	1.39A	3w1wA-4k0eA: undetectable 3w1wB-4k0eA: undetectable	3w1wA-4k0eA: 16.01 3w1wB-4k0eA: 16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_B_CHDB506_0 (FERROCHELATASE, MITOCHONDRIAL)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	3 / 3	ARG A 412 ARG A 423 LYS A 423	None	1.44A	3w1wA-4k0eA: undetectable 3w1wB-4k0eA: undetectable	3w1wA-4k0eA: 16.01 3w1wB-4k0eA: 16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A9J_A_TYLA1188_1 (BROMODOMAIN CONTAINING 2)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 5	VAL A 50 LEU A 92 LEU A 90 ASN A 597	None	0.95A	4a9jA-4k0eA: 2.1	4a9jA-4k0eA: 9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A9J_B_TYLB1187_1 (BROMODOMAIN CONTAINING 2)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 5	VAL A 50 LEU A 92 LEU A 90 ASN A 597	None	0.91A	4a9jB-4k0eA: undetectable	4a9jB-4k0eA: 9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A9J_C_TYLC1184_1 (BROMODOMAIN CONTAINING 2)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 5	VAL A 50 LEU A 92 LEU A 90 ASN A 597	None	0.89A	4a9jC-4k0eA: 2.1	4a9jC-4k0eA: 9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4COX_C_IMNC701_1 (CYCLOOXYGENASE-2)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	VAL A 923 LEU A 926 VAL A 961 ALA A 965 LEU A 997	None	1.06A	4coxC-4k0eA: 0.7	4coxC-4k0eA: 20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EJJ_C_NCTC501_1 (CYTOCHROME P450 2A6)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 5	PHE A 157 ILE A 280 GLY A 178 THR A 180	None	0.82A	4ejjC-4k0eA: undetectable	4ejjC-4k0eA: 18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_A_SAMA301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	ALA A 475 ASP A 393 LEU A 972 ALA A 471 TYR A 447	None	1.06A	4lg1A-4k0eA: undetectable	4lg1A-4k0eA: 13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_A_SAMA301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	ALA A 475 GLY A 395 ASP A 393 LEU A 972 TYR A 447	None	1.03A	4lg1A-4k0eA: undetectable	4lg1A-4k0eA: 13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_C_SAMC301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	ALA A 475 ASP A 393 LEU A 972 ALA A 471 TYR A 447	None	1.08A	4lg1C-4k0eA: undetectable	4lg1C-4k0eA: 13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LG1_C_SAMC301_0 (PROTEIN-LYSINE METHYLTRANSFERASE METTL21D)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	ALA A 475 GLY A 395 ASP A 393 LEU A 972 TYR A 447	None	1.06A	4lg1C-4k0eA: undetectable	4lg1C-4k0eA: 13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LRH_A_FOLA301_1 (FOLATE RECEPTOR ALPHA)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	3 / 3	ASP A 328 TRP A 28 SER A 293	None	0.92A	4lrhA-4k0eA: undetectable	4lrhA-4k0eA: 10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LRH_F_FOLF301_1 (FOLATE RECEPTOR ALPHA)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	3 / 3	ASP A 328 TRP A 31 SER A 293	None	1.03A	4lrhF-4k0eA: undetectable	4lrhF-4k0eA: 10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P3Q_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 5	ASP A 545 LEU A 819 ARG A 827 THR A 908	None	1.30A	4p3qA-4k0eA: undetectable	4p3qA-4k0eA: 8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QTU_D_SAMD301_1 (PUTATIVE METHYLTRANSFERASE BUD23)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 5	GLN A 986 LEU A 989 SER A 912 ASP A 41	None	1.15A	4qtuD-4k0eA: undetectable	4qtuD-4k0eA: 12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WG0_F_CHDF103_0 (NUCLEAR RECEPTOR COACTIVATOR 2)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 11	LEU A 814 LEU A 667 LEU A 819 GLU A 824 LEU A 823	None	0.76A	4wg0F-4k0eA: undetectable 4wg0G-4k0eA: undetectable 4wg0H-4k0eA: undetectable	4wg0F-4k0eA: 2.06 4wg0G-4k0eA: 2.06 4wg0H-4k0eA: 2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WG0_J_CHDJ103_0 (NUCLEAR RECEPTOR COACTIVATOR 2)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 11	LEU A 814 LEU A 667 LEU A 819 GLU A 824 LEU A 823	None	0.86A	4wg0J-4k0eA: undetectable 4wg0K-4k0eA: undetectable 4wg0L-4k0eA: undetectable	4wg0J-4k0eA: 2.06 4wg0K-4k0eA: 2.06 4wg0L-4k0eA: 2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WG0_K_CHDK103_0 (NUCLEAR RECEPTOR COACTIVATOR 2)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 11	GLU A 824 LEU A 823 LEU A 819 LEU A 814 LEU A 667	None	0.97A	4wg0I-4k0eA: undetectable 4wg0J-4k0eA: undetectable 4wg0K-4k0eA: undetectable	4wg0I-4k0eA: 2.06 4wg0J-4k0eA: 2.06 4wg0K-4k0eA: 2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X61_A_SAMA701_0 (PROTEIN ARGININE N-METHYLTRANSFERASE 5)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	LEU A 690 GLY A 846 GLY A 662 LEU A 660 LEU A 667	None	1.33A	4x61A-4k0eA: undetectable	4x61A-4k0eA: 22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YGF_A_AZMA303_1 (ALPHA-CARBONIC ANHYDRASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 11	ASN A 778 HIS A 781 LEU A 774 THR A 773 ALA A 783	None	1.23A	4ygfA-4k0eA: undetectable	4ygfA-4k0eA: 12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YGF_C_AZMC303_1 (ALPHA-CARBONIC ANHYDRASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 11	ASN A 778 HIS A 781 LEU A 774 THR A 773 ALA A 783	None	1.25A	4ygfC-4k0eA: undetectable	4ygfC-4k0eA: 12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YGF_D_AZMD303_1 (ALPHA-CARBONIC ANHYDRASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 11	ASN A 778 HIS A 781 LEU A 774 THR A 773 ALA A 783	None	1.32A	4ygfD-4k0eA: undetectable	4ygfD-4k0eA: 12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZZC_A_ACTA401_0 (PROTON-GATED ION CHANNEL)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 6	ILE A 799 ARG A 806 ILE A 67 GLU A 70	None	1.04A	4zzcA-4k0eA: 2.4 4zzcB-4k0eA: 2.3	4zzcA-4k0eA: 15.59 4zzcB-4k0eA: 15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZZC_B_ACTB401_0 (PROTON-GATED ION CHANNEL)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 6	ILE A 799 ARG A 806 ILE A 67 GLU A 70	None	0.97A	4zzcB-4k0eA: 2.3 4zzcC-4k0eA: 2.3	4zzcB-4k0eA: 15.59 4zzcC-4k0eA: 15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B8H_A_PAUA302_0 (TYPE III PANTOTHENATE KINASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	GLY A 571 ASP A 575 THR A 592 ILE A 609 LEU A 561	None	1.27A	5b8hA-4k0eA: undetectable 5b8hB-4k0eA: undetectable	5b8hA-4k0eA: 14.35 5b8hB-4k0eA: 14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EB3_A_UEGA202_1 (YFIR)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 4	LEU A 311 ILE A 310 PRO A 162 LEU A 164	None	0.94A	5eb3A-4k0eA: undetectable	5eb3A-4k0eA: 10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HS1_A_VORA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 8	ILE A 700 THR A 611 LEU A 577 LEU A 641	None	0.83A	5hs1A-4k0eA: undetectable	5hs1A-4k0eA: 19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I1O_F_DVAF9_0 (D-VILLIN HEADPIECE SUBDOMAIN VILLIN-1)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	3 / 3	ALA A 768 ASN A 771 LEU A 772	None	0.15A	5i1oC-4k0eA: undetectable	5i1oC-4k0eA: 3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I1P_F_DVAF9_0 (D-VILLIN HEADPIECE SUBDOMAIN VILLIN-1)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	3 / 3	ALA A 768 ASN A 771 LEU A 772	None	0.18A	5i1pA-4k0eA: undetectable	5i1pA-4k0eA: 3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KIR_A_RCXA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	VAL A 923 LEU A 926 VAL A 961 ALA A 965 LEU A 997	None	1.06A	5kirA-4k0eA: 0.6	5kirA-4k0eA: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M8R_A_MMSA511_1 (5,6-DIHYDROXYINDOLE- 2-CARBOXYLIC ACID OXIDASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 7	ASN A 771 LEU A 772 VAL A 190 SER A 193	None	0.96A	5m8rA-4k0eA: undetectable	5m8rA-4k0eA: 17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M8R_D_MMSD509_1 (5,6-DIHYDROXYINDOLE- 2-CARBOXYLIC ACID OXIDASE)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 8	ASN A 771 LEU A 772 VAL A 190 SER A 193	None	0.96A	5m8rD-4k0eA: undetectable	5m8rD-4k0eA: 17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NJV_D_SAMD301_0 (NS5)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	GLY A 177 GLY A 600 THR A 601 VAL A 50 ASP A 598	None	1.05A	5njvD-4k0eA: undetectable	5njvD-4k0eA: 13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYE_B_TA1B502_1 (TUBULIN BETA CHAIN)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 12	VAL A 993 LEU A 472 ASP A 399 ALA A 919 GLY A 390	None	1.22A	5syeB-4k0eA: undetectable	5syeB-4k0eA: 17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_B_PCFB1802_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 7	SER A 369 THR A 365 VAL A 362 ILE A 436	None	1.24A	5vkqA-4k0eA: 4.1 5vkqB-4k0eA: 4.1	5vkqA-4k0eA: 21.67 5vkqB-4k0eA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_D_PCFD1803_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 7	SER A 369 THR A 365 VAL A 362 ILE A 436	None	1.23A	5vkqC-4k0eA: 4.1 5vkqD-4k0eA: 4.1	5vkqC-4k0eA: 21.67 5vkqD-4k0eA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_C_CVIC301_1 (REGULATORY PROTEIN TETR)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 7	GLN A 697 GLY A 816 GLN A 852 ASP A 818	None	1.10A	5vlmC-4k0eA: 1.1	5vlmC-4k0eA: 12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_E_CVIE301_1 (REGULATORY PROTEIN TETR)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 7	GLN A 697 GLY A 816 GLN A 852 ASP A 818	None	1.15A	5vlmE-4k0eA: undetectable	5vlmE-4k0eA: 12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W7P_A_SAMA501_1 (OXAC)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	4 / 5	HIS A 608 ASP A 602 ASP A 128 ARG A 811	None ZN A1101 ( 3.6A) None None	1.47A	5w7pA-4k0eA: 0.2	5w7pA-4k0eA: 16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_I_PCFI101_0 (CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL CYTOCHROME B-C1 COMPLEX SUBUNIT 9 CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 11	VAL A 967 GLY A 395 ALA A 471 ASN A 927 VAL A 923	None	1.45A	6hu9A-4k0eA: undetectable 6hu9E-4k0eA: undetectable 6hu9I-4k0eA: undetectable	6hu9A-4k0eA: 18.85 6hu9E-4k0eA: 11.84 6hu9I-4k0eA: 4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_T_PCFT101_0 (CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL CYTOCHROME B-C1 COMPLEX SUBUNIT 9 CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 10	VAL A 967 GLY A 395 ALA A 471 ASN A 927 VAL A 923	None	1.45A	6hu9L-4k0eA: undetectable 6hu9P-4k0eA: undetectable 6hu9T-4k0eA: undetectable	6hu9L-4k0eA: 18.85 6hu9P-4k0eA: 11.84 6hu9T-4k0eA: 4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NM4_B_SAMB402_0 (HISTONE-LYSINE N-METHYLTRANSFERASE PRDM9)	4k0e	HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE) (Cupriavidus metallidurans)	5 / 9	ILE A 397 ALA A 471 GLY A 474 LEU A 477 GLY A 27	None	0.96A	6nm4B-4k0eA: undetectable	6nm4B-4k0eA: 9.73

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EQH_A_FLPA701_1","PROSTAGLANDIN H2 SYNTHASE-1","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"VAL A 993;ILE A 392;GLY A 390;ALA A 391;LEU A 989","None","0.93A","1eqhA-4k0eA:undetectable","1eqhA-4k0eA:21.28"],["1EQH_B_FLPB1701_1","PROSTAGLANDIN H2 SYNTHASE-1","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"VAL A 993;ILE A 392;GLY A 390;ALA A 391;LEU A 989","None","0.93A","1eqhB-4k0eA:undetectable","1eqhB-4k0eA:21.28"],["1J8U_A_H4BA429_1","PHENYLALANINE-4-HYDROXYLASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"LEU A 344;SER A 346;LEU A 349;ALA A 363","None","0.87A","1j8uA-4k0eA:undetectable","1j8uA-4k0eA:15.21"],["1JG4_A_SAMA500_0","PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"GLN A 281;VAL A 594;GLY A 272;THR A 611;ALA A 612","None","1.07A","1jg4A-4k0eA:undetectable","1jg4A-4k0eA:12.00"],["1MX1_B_THAB2_1","LIVER CARBOXYLESTERASE I","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 338;GLY A 390;VAL A 915;LEU A 972;LEU A 989","None","1.11A","1mx1B-4k0eA:2.4","1mx1B-4k0eA:20.59"],["1MX1_C_THAC3_1","LIVER CARBOXYLESTERASE I","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 338;GLY A 390;VAL A 915;LEU A 972;LEU A 989","None","1.09A","1mx1C-4k0eA:2.5","1mx1C-4k0eA:20.59"],["1MX1_E_THAE5_1","LIVER CARBOXYLESTERASE I","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 338;GLY A 390;VAL A 915;LEU A 972;LEU A 989","None","1.13A","1mx1E-4k0eA:2.4","1mx1E-4k0eA:20.59"],["1ONI_A_BEZA501_0","14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"PHE A 451;ALA A 465;TYR A 458;ILE A 382","None","1.11A","1oniA-4k0eA:undetectable;1oniB-4k0eA:undetectable","1oniA-4k0eA:9.30;1oniB-4k0eA:9.30"],["1ONI_I_BEZI517_0","14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"TYR A 458;ILE A 382;PHE A 451;ALA A 465","None","1.06A","1oniG-4k0eA:undetectable;1oniI-4k0eA:undetectable","1oniG-4k0eA:9.30;1oniI-4k0eA:9.30"],["1R9O_A_FLPA501_1","CYTOCHROME P450 2C9","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",6,"ILE A 397;VAL A 923;GLY A 400;ALA A 401;THR A 365;LEU A 349","None","1.47A","1r9oA-4k0eA:undetectable","1r9oA-4k0eA:19.16"],["1S9P_A_DESA459_1","ESTROGEN-RELATED RECEPTOR GAMMA","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 481;LEU A 477;ALA A 475;MET A 440;LEU A 472","None","1.13A","1s9pA-4k0eA:undetectable","1s9pA-4k0eA:13.39"],["1W0G_A_MYTA1499_1","CYTOCHROME P450 3A4","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"ILE A 929;ALA A 928;THR A1004;ALA A 894","None","0.95A","1w0gA-4k0eA:0.7","1w0gA-4k0eA:18.06"],["2CL5_B_SAMB1217_1","CATECHOL O-METHYLTRANSFERASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"GLU A 552;TYR A  39;GLN A 628;ASP A 654","None","1.31A","2cl5B-4k0eA:undetectable","2cl5B-4k0eA:12.31"],["2GLU_B_SAMB302_0","YCGJ","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"GLY A 898;GLY A 995;ALA A 894;ARG A 905;PHE A 917","None","1.00A","2gluB-4k0eA:undetectable","2gluB-4k0eA:12.81"],["2KCE_A_D16A566_1","THYMIDYLATE SYNTHASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 482;GLY A 474;PHE A 473;VAL A  23;ALA A  24","None","1.26A","2kceA-4k0eA:undetectable","2kceA-4k0eA:13.01"],["2PNJ_A_CHDA501_0","FERROCHELATASE, MITOCHONDRIAL","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 823;PHE A 822;LEU A 819;ILE A 830;LEU A 660","None","0.99A","2pnjA-4k0eA:undetectable","2pnjA-4k0eA:15.50"],["2PO5_A_CHDA501_0","FERROCHELATASE, MITOCHONDRIAL","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 823;PHE A 822;LEU A 819;ILE A 830;LEU A 660","None","0.89A","2po5A-4k0eA:undetectable","2po5A-4k0eA:15.98"],["2PO7_A_CHDA501_0","FERROCHELATASE, MITOCHONDRIAL","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 823;PHE A 822;LEU A 819;ILE A 830;LEU A 660","None","0.96A","2po7A-4k0eA:undetectable","2po7A-4k0eA:15.61"],["2PO7_B_CHDB501_0","FERROCHELATASE, MITOCHONDRIAL","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 823;PHE A 822;LEU A 819;ILE A 830;LEU A 660","None","0.99A","2po7B-4k0eA:undetectable","2po7B-4k0eA:15.61"],["2V0M_B_KLNB1498_1","CYTOCHROME P450 3A4","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"ILE A 321;ALA A 612;GLU A 599;GLY A 177;LEU A 271","None;None; ZN A1102 ( 4.9A);None;None","1.25A","2v0mB-4k0eA:undetectable","2v0mB-4k0eA:18.06"],["2X9G_A_LYAA1270_2","PTERIDINE REDUCTASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",3,"MET A 573;VAL A 613;GLU A 583","None","0.90A","2x9gA-4k0eA:undetectable","2x9gA-4k0eA:14.68"],["2ZJ0_D_2FAD500_2","ADENOSYLHOMOCYSTEINASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"LEU A 808;GLN A 681;THR A 679;THR A 797","None","1.50A","2zj0D-4k0eA:undetectable","2zj0D-4k0eA:20.32"],["2ZVJ_A_SAMA301_1","CATECHOL O-METHYLTRANSFERASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"GLU A 552;TYR A  39;GLN A 628;ASP A 654","None","1.34A","2zvjA-4k0eA:undetectable","2zvjA-4k0eA:12.46"],["3A7E_A_SAMA216_1","CATECHOL O-METHYLTRANSFERASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"GLY A 655;ILE A 653;ILE A  42;ASP A 658","None","0.93A","3a7eA-4k0eA:undetectable","3a7eA-4k0eA:12.28"],["3AVP_A_MV2A313_1","PANTOTHENATE KINASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"ASP A 393;LEU A 997;ILE A 930;ASN A 927","None","1.00A","3avpA-4k0eA:undetectable","3avpA-4k0eA:15.56"],["3B9L_A_AZZA1009_1","SERUM ALBUMIN","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"GLU A 704;SER A 605;HIS A 664;ARG A 811","None","0.93A","3b9lA-4k0eA:3.3","3b9lA-4k0eA:20.45"],["3BEX_F_PAUF248_0","TYPE III PANTOTHENATE KINASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 561;GLY A 571;ASP A 575;THR A 592;ILE A 609","None","1.28A","3bexE-4k0eA:undetectable;3bexF-4k0eA:undetectable","3bexE-4k0eA:13.57;3bexF-4k0eA:13.57"],["3BF1_C_PAUC248_0","TYPE III PANTOTHENATE KINASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"GLY A 571;THR A 592;ILE A 609;THR A 644;LEU A 561","None","1.42A","3bf1C-4k0eA:undetectable;3bf1D-4k0eA:undetectable","3bf1C-4k0eA:13.57;3bf1D-4k0eA:13.57"],["3BF1_D_PAUD248_0","TYPE III PANTOTHENATE KINASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 561;GLY A 571;ASP A 575;THR A 592;ILE A 609","None","1.27A","3bf1C-4k0eA:undetectable;3bf1D-4k0eA:undetectable","3bf1C-4k0eA:13.57;3bf1D-4k0eA:13.57"],["3BXO_A_SAMA238_1","N,N-DIMETHYLTRANSFERASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",3,"TYR A 140;GLU A 136;ASP A 658","None","0.81A","3bxoA-4k0eA:undetectable","3bxoA-4k0eA:13.74"],["3BXO_B_SAMB238_1","N,N-DIMETHYLTRANSFERASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",3,"TYR A 140;GLU A 136;ASP A 658","None","0.77A","3bxoB-4k0eA:undetectable","3bxoB-4k0eA:13.74"],["3CL9_A_MTXA602_2","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS)","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"VAL A 559;ARG A 637;ILE A 631;THR A 592","None","1.23A","3cl9A-4k0eA:undetectable","3cl9A-4k0eA:19.81"],["3CLD_B_GW6B2_2","GLUCOCORTICOID RECEPTOR","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"MET A 573;ALA A 574;LEU A 577;GLN A 558","None","0.94A","3cldB-4k0eA:undetectable","3cldB-4k0eA:12.79"],["3FI0_C_TRPC1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"GLY A 739;GLN A 182;VAL A 755;ILE A 737;GLN A 266","None","1.45A","3fi0C-4k0eA:undetectable","3fi0C-4k0eA:15.94"],["3FI0_F_TRPF1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"GLY A 739;GLN A 182;VAL A 755;ILE A 737;GLN A 266","None","1.37A","3fi0F-4k0eA:undetectable","3fi0F-4k0eA:15.94"],["3FI0_J_TRPJ1001_0","TRYPTOPHANYL-TRNA SYNTHETASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"GLY A 739;GLN A 182;VAL A 755;ILE A 737;GLN A 266","None","1.33A","3fi0J-4k0eA:undetectable","3fi0J-4k0eA:15.94"],["3GLQ_A_RABA602_2","ADENOSYLHOMOCYSTEINASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"GLN A 681;THR A 679;GLU A 796;THR A 797","None","1.41A","3glqA-4k0eA:undetectable","3glqA-4k0eA:20.08"],["3HCO_A_CHDA3_0","FERROCHELATASE, MITOCHONDRIAL","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"LEU A 517;PRO A1009;LEU A 514;ARG A 509","None","1.24A","3hcoA-4k0eA:undetectable","3hcoA-4k0eA:16.17"],["3U5K_A_08JA1_1","BROMODOMAIN-CONTAINING PROTEIN 4","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"VAL A  50;LEU A  92;LEU A  90;ASN A 597","None","0.87A","3u5kA-4k0eA:undetectable","3u5kA-4k0eA:7.27"],["3U5K_B_08JB2_1","BROMODOMAIN-CONTAINING PROTEIN 4","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"VAL A  50;LEU A  92;LEU A  90;ASN A 597","None","0.97A","3u5kB-4k0eA:undetectable","3u5kB-4k0eA:7.27"],["3U5K_C_08JC3_1","BROMODOMAIN-CONTAINING PROTEIN 4","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"VAL A  50;LEU A  92;LEU A  90;ASN A 597","None","0.87A","3u5kC-4k0eA:undetectable","3u5kC-4k0eA:7.27"],["3W1W_A_CHDA1507_0","FERROCHELATASE, MITOCHONDRIAL","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",3,"ARG A 423;LYS A 423;ARG A 412","None","1.39A","3w1wA-4k0eA:undetectable;3w1wB-4k0eA:undetectable","3w1wA-4k0eA:16.01;3w1wB-4k0eA:16.01"],["3W1W_B_CHDB506_0","FERROCHELATASE, MITOCHONDRIAL","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",3,"ARG A 412;ARG A 423;LYS A 423","None","1.44A","3w1wA-4k0eA:undetectable;3w1wB-4k0eA:undetectable","3w1wA-4k0eA:16.01;3w1wB-4k0eA:16.01"],["4A9J_A_TYLA1188_1","BROMODOMAIN CONTAINING 2","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"VAL A  50;LEU A  92;LEU A  90;ASN A 597","None","0.95A","4a9jA-4k0eA:2.1","4a9jA-4k0eA:9.51"],["4A9J_B_TYLB1187_1","BROMODOMAIN CONTAINING 2","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"VAL A  50;LEU A  92;LEU A  90;ASN A 597","None","0.91A","4a9jB-4k0eA:undetectable","4a9jB-4k0eA:9.51"],["4A9J_C_TYLC1184_1","BROMODOMAIN CONTAINING 2","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"VAL A  50;LEU A  92;LEU A  90;ASN A 597","None","0.89A","4a9jC-4k0eA:2.1","4a9jC-4k0eA:9.51"],["4COX_C_IMNC701_1","CYCLOOXYGENASE-2","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"VAL A 923;LEU A 926;VAL A 961;ALA A 965;LEU A 997","None","1.06A","4coxC-4k0eA:0.7","4coxC-4k0eA:20.11"],["4EJJ_C_NCTC501_1","CYTOCHROME P450 2A6","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"PHE A 157;ILE A 280;GLY A 178;THR A 180","None","0.82A","4ejjC-4k0eA:undetectable","4ejjC-4k0eA:18.31"],["4LG1_A_SAMA301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"ALA A 475;ASP A 393;LEU A 972;ALA A 471;TYR A 447","None","1.06A","4lg1A-4k0eA:undetectable","4lg1A-4k0eA:13.09"],["4LG1_A_SAMA301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"ALA A 475;GLY A 395;ASP A 393;LEU A 972;TYR A 447","None","1.03A","4lg1A-4k0eA:undetectable","4lg1A-4k0eA:13.09"],["4LG1_C_SAMC301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"ALA A 475;ASP A 393;LEU A 972;ALA A 471;TYR A 447","None","1.08A","4lg1C-4k0eA:undetectable","4lg1C-4k0eA:13.09"],["4LG1_C_SAMC301_0","PROTEIN-LYSINE METHYLTRANSFERASE METTL21D","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"ALA A 475;GLY A 395;ASP A 393;LEU A 972;TYR A 447","None","1.06A","4lg1C-4k0eA:undetectable","4lg1C-4k0eA:13.09"],["4LRH_A_FOLA301_1","FOLATE RECEPTOR ALPHA","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",3,"ASP A 328;TRP A  28;SER A 293","None","0.92A","4lrhA-4k0eA:undetectable","4lrhA-4k0eA:10.95"],["4LRH_F_FOLF301_1","FOLATE RECEPTOR ALPHA","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",3,"ASP A 328;TRP A  31;SER A 293","None","1.03A","4lrhF-4k0eA:undetectable","4lrhF-4k0eA:10.95"],["4P3Q_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"ASP A 545;LEU A 819;ARG A 827;THR A 908","None","1.30A","4p3qA-4k0eA:undetectable","4p3qA-4k0eA:8.94"],["4QTU_D_SAMD301_1","PUTATIVE METHYLTRANSFERASE BUD23","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"GLN A 986;LEU A 989;SER A 912;ASP A  41","None","1.15A","4qtuD-4k0eA:undetectable","4qtuD-4k0eA:12.38"],["4WG0_F_CHDF103_0","NUCLEAR RECEPTOR COACTIVATOR 2","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 814;LEU A 667;LEU A 819;GLU A 824;LEU A 823","None","0.76A","4wg0F-4k0eA:undetectable;4wg0G-4k0eA:undetectable;4wg0H-4k0eA:undetectable","4wg0F-4k0eA:2.06;4wg0G-4k0eA:2.06;4wg0H-4k0eA:2.06"],["4WG0_J_CHDJ103_0","NUCLEAR RECEPTOR COACTIVATOR 2","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 814;LEU A 667;LEU A 819;GLU A 824;LEU A 823","None","0.86A","4wg0J-4k0eA:undetectable;4wg0K-4k0eA:undetectable;4wg0L-4k0eA:undetectable","4wg0J-4k0eA:2.06;4wg0K-4k0eA:2.06;4wg0L-4k0eA:2.06"],["4WG0_K_CHDK103_0","NUCLEAR RECEPTOR COACTIVATOR 2","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"GLU A 824;LEU A 823;LEU A 819;LEU A 814;LEU A 667","None","0.97A","4wg0I-4k0eA:undetectable;4wg0J-4k0eA:undetectable;4wg0K-4k0eA:undetectable","4wg0I-4k0eA:2.06;4wg0J-4k0eA:2.06;4wg0K-4k0eA:2.06"],["4X61_A_SAMA701_0","PROTEIN ARGININE N-METHYLTRANSFERASE 5","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"LEU A 690;GLY A 846;GLY A 662;LEU A 660;LEU A 667","None","1.33A","4x61A-4k0eA:undetectable","4x61A-4k0eA:22.29"],["4YGF_A_AZMA303_1","ALPHA-CARBONIC ANHYDRASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"ASN A 778;HIS A 781;LEU A 774;THR A 773;ALA A 783","None","1.23A","4ygfA-4k0eA:undetectable","4ygfA-4k0eA:12.77"],["4YGF_C_AZMC303_1","ALPHA-CARBONIC ANHYDRASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"ASN A 778;HIS A 781;LEU A 774;THR A 773;ALA A 783","None","1.25A","4ygfC-4k0eA:undetectable","4ygfC-4k0eA:12.77"],["4YGF_D_AZMD303_1","ALPHA-CARBONIC ANHYDRASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"ASN A 778;HIS A 781;LEU A 774;THR A 773;ALA A 783","None","1.32A","4ygfD-4k0eA:undetectable","4ygfD-4k0eA:12.77"],["4ZZC_A_ACTA401_0","PROTON-GATED ION CHANNEL","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"ILE A 799;ARG A 806;ILE A  67;GLU A  70","None","1.04A","4zzcA-4k0eA:2.4;4zzcB-4k0eA:2.3","4zzcA-4k0eA:15.59;4zzcB-4k0eA:15.59"],["4ZZC_B_ACTB401_0","PROTON-GATED ION CHANNEL","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"ILE A 799;ARG A 806;ILE A  67;GLU A  70","None","0.97A","4zzcB-4k0eA:2.3;4zzcC-4k0eA:2.3","4zzcB-4k0eA:15.59;4zzcC-4k0eA:15.59"],["5B8H_A_PAUA302_0","TYPE III PANTOTHENATE KINASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"GLY A 571;ASP A 575;THR A 592;ILE A 609;LEU A 561","None","1.27A","5b8hA-4k0eA:undetectable;5b8hB-4k0eA:undetectable","5b8hA-4k0eA:14.35;5b8hB-4k0eA:14.35"],["5EB3_A_UEGA202_1","YFIR","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"LEU A 311;ILE A 310;PRO A 162;LEU A 164","None","0.94A","5eb3A-4k0eA:undetectable","5eb3A-4k0eA:10.86"],["5HS1_A_VORA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"ILE A 700;THR A 611;LEU A 577;LEU A 641","None","0.83A","5hs1A-4k0eA:undetectable","5hs1A-4k0eA:19.41"],["5I1O_F_DVAF9_0","D-VILLIN HEADPIECE SUBDOMAIN;VILLIN-1","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",3,"ALA A 768;ASN A 771;LEU A 772","None","0.15A","5i1oC-4k0eA:undetectable","5i1oC-4k0eA:3.50"],["5I1P_F_DVAF9_0","D-VILLIN HEADPIECE SUBDOMAIN;VILLIN-1","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",3,"ALA A 768;ASN A 771;LEU A 772","None","0.18A","5i1pA-4k0eA:undetectable","5i1pA-4k0eA:3.61"],["5KIR_A_RCXA601_1","PROSTAGLANDIN G\/H SYNTHASE 2","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"VAL A 923;LEU A 926;VAL A 961;ALA A 965;LEU A 997","None","1.06A","5kirA-4k0eA:0.6","5kirA-4k0eA:19.11"],["5M8R_A_MMSA511_1","5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID OXIDASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"ASN A 771;LEU A 772;VAL A 190;SER A 193","None","0.96A","5m8rA-4k0eA:undetectable","5m8rA-4k0eA:17.79"],["5M8R_D_MMSD509_1","5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID OXIDASE","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"ASN A 771;LEU A 772;VAL A 190;SER A 193","None","0.96A","5m8rD-4k0eA:undetectable","5m8rD-4k0eA:17.79"],["5NJV_D_SAMD301_0","NS5","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"GLY A 177;GLY A 600;THR A 601;VAL A  50;ASP A 598","None","1.05A","5njvD-4k0eA:undetectable","5njvD-4k0eA:13.49"],["5SYE_B_TA1B502_1","TUBULIN BETA CHAIN","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"VAL A 993;LEU A 472;ASP A 399;ALA A 919;GLY A 390","None","1.22A","5syeB-4k0eA:undetectable","5syeB-4k0eA:17.99"],["5VKQ_B_PCFB1802_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"SER A 369;THR A 365;VAL A 362;ILE A 436","None","1.24A","5vkqA-4k0eA:4.1;5vkqB-4k0eA:4.1","5vkqA-4k0eA:21.67;5vkqB-4k0eA:21.67"],["5VKQ_D_PCFD1803_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"SER A 369;THR A 365;VAL A 362;ILE A 436","None","1.23A","5vkqC-4k0eA:4.1;5vkqD-4k0eA:4.1","5vkqC-4k0eA:21.67;5vkqD-4k0eA:21.67"],["5VLM_C_CVIC301_1","REGULATORY PROTEIN TETR","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"GLN A 697;GLY A 816;GLN A 852;ASP A 818","None","1.10A","5vlmC-4k0eA:1.1","5vlmC-4k0eA:12.08"],["5VLM_E_CVIE301_1","REGULATORY PROTEIN TETR","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"GLN A 697;GLY A 816;GLN A 852;ASP A 818","None","1.15A","5vlmE-4k0eA:undetectable","5vlmE-4k0eA:12.08"],["5W7P_A_SAMA501_1","OXAC","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",4,"HIS A 608;ASP A 602;ASP A 128;ARG A 811","None; ZN A1101 ( 3.6A);None;None","1.47A","5w7pA-4k0eA:0.2","5w7pA-4k0eA:16.79"],["6HU9_I_PCFI101_0","CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL;CYTOCHROME B-C1 COMPLEX SUBUNIT 9;CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"VAL A 967;GLY A 395;ALA A 471;ASN A 927;VAL A 923","None","1.45A","6hu9A-4k0eA:undetectable;6hu9E-4k0eA:undetectable;6hu9I-4k0eA:undetectable","6hu9A-4k0eA:18.85;6hu9E-4k0eA:11.84;6hu9I-4k0eA:4.83"],["6HU9_T_PCFT101_0","CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL;CYTOCHROME B-C1 COMPLEX SUBUNIT 9;CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"VAL A 967;GLY A 395;ALA A 471;ASN A 927;VAL A 923","None","1.45A","6hu9L-4k0eA:undetectable;6hu9P-4k0eA:undetectable;6hu9T-4k0eA:undetectable","6hu9L-4k0eA:18.85;6hu9P-4k0eA:11.84;6hu9T-4k0eA:4.83"],["6NM4_B_SAMB402_0","HISTONE-LYSINE N-METHYLTRANSFERASE PRDM9","4k0e","HEAVY METAL CATION TRICOMPONENT EFFLUX PUMP ZNEA(CZCA-LIKE)","Cupriavidus metallidurans",5,"ILE A 397;ALA A 471;GLY A 474;LEU A 477;GLY A  27","None","0.96A","6nm4B-4k0eA:undetectable","6nm4B-4k0eA:9.73"]]