SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k0r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 ARG A  10
GLY A 106
ASP A 110
 None
 0.22A 1kf6A-4k0rA:
undetectable
1kf6B-4k0rA:
undetectable		 1kf6A-4k0rA:
22.00
1kf6B-4k0rA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		5 / 11 GLY A  27
ALA A  28
ILE A  93
ILE A 125
ILE A  31
 None
 0.89A 1n49B-4k0rA:
undetectable		 1n49B-4k0rA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		5 / 11 GLY A  27
ALA A  28
ILE A  93
ILE A 125
ILE A  31
 None
 0.89A 1n49C-4k0rA:
undetectable		 1n49C-4k0rA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		5 / 12 THR A 301
GLU A 103
GLY A 106
ILE A  98
ALA A  20
 None
 1.38A 1oltA-4k0rA:
undetectable		 1oltA-4k0rA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		4 / 5 GLU A 452
PRO A 451
ILE A 454
GLY A 453
 None
 1.15A 2qeuA-4k0rA:
0.6
2qeuC-4k0rA:
0.8		 2qeuA-4k0rA:
13.32
2qeuC-4k0rA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 TRP A 320
GLN A 317
TRP A 399
 None
 1.00A 2vqyA-4k0rA:
undetectable		 2vqyA-4k0rA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		5 / 12 LEU A 385
ARG A 358
HIS A 354
ALA A 246
SER A 247
 None
 1.19A 3apvA-4k0rA:
undetectable		 3apvA-4k0rA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		5 / 10 GLY A  27
ALA A  28
ASN A   4
ILE A  93
ILE A 125
 None
 0.92A 3lzvA-4k0rA:
undetectable		 3lzvA-4k0rA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 PHE A   9
CYH A  33
HIS A   7
 None
 1.05A 3u9fF-4k0rA:
undetectable		 3u9fF-4k0rA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 PHE A   9
CYH A  33
HIS A   7
 None
 1.11A 3u9fG-4k0rA:
undetectable		 3u9fG-4k0rA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 PHE A   9
CYH A  33
HIS A   7
 None
 1.03A 3u9fL-4k0rA:
undetectable		 3u9fL-4k0rA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 PHE A   9
CYH A  33
HIS A   7
 None
 1.15A 3u9fS-4k0rA:
undetectable		 3u9fS-4k0rA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 ARG A  14
GLU A  99
ASN A  18
 None
 0.79A 4imaD-4k0rA:
undetectable		 4imaD-4k0rA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 ARG A  14
GLU A  99
ASN A  18
 None
 0.77A 4ip7D-4k0rA:
undetectable		 4ip7D-4k0rA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		5 / 12 ASP A  61
LEU A  62
LEU A 386
GLY A 258
LEU A 218
 None
 1.25A 4retA-4k0rA:
undetectable		 4retA-4k0rA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		5 / 12 ASP A  61
LEU A  62
LEU A 386
GLY A 258
LEU A 218
 None
 1.24A 4retC-4k0rA:
undetectable		 4retC-4k0rA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 GLY A 250
LEU A 251
HIS A 224
 None
 0.40A 5u63A-4k0rA:
undetectable		 5u63A-4k0rA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		3 / 3 GLY A 250
LEU A 251
HIS A 224
 None
 0.41A 5u63B-4k0rA:
undetectable		 5u63B-4k0rA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4k0r CRYPTOCHROME-1
(Mus
musculus) 		5 / 12 ILE A 314
LEU A 156
PRO A 146
LEU A 148
PHE A 295
 None
 1.22A 5xxiA-4k0rA:
undetectable		 5xxiA-4k0rA:
21.22