SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k0v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4k0v TEK TYROSINE KINASE
VARIANT
(Homo
sapiens) 		3 / 3 PHE A 536
TYR A 513
TYR A 483
 None
 1.08A 1x70B-4k0vA:
undetectable		 1x70B-4k0vA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 4k0v TEK TYROSINE KINASE
VARIANT
(Homo
sapiens) 		4 / 4 GLU A 235
GLY A 238
THR A 237
GLU A 239
 None
 1.10A 3e9xA-4k0vA:
undetectable		 3e9xA-4k0vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k0v TEK TYROSINE KINASE
VARIANT
(Homo
sapiens) 		3 / 3 THR A 225
GLU A 381
HIS A 394
 None
 0.73A 3g1uB-4k0vA:
undetectable		 3g1uB-4k0vA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 4k0v TEK TYROSINE KINASE
VARIANT
(Homo
sapiens) 		3 / 3 VAL A 429
GLY A 431
LYS A 253
 None
 0.56A 4k50A-4k0vA:
undetectable		 4k50A-4k0vA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 4k0v TEK TYROSINE KINASE
VARIANT
(Homo
sapiens) 		3 / 3 VAL A 429
GLY A 431
LYS A 253
 None
 0.52A 4k50E-4k0vA:
undetectable		 4k50E-4k0vA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 4k0v TEK TYROSINE KINASE
VARIANT
(Homo
sapiens) 		3 / 3 VAL A 429
GLY A 431
LYS A 253
 None
 0.58A 4k50I-4k0vA:
undetectable		 4k50I-4k0vA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6H_A_MTXA803_1
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4k0v TEK TYROSINE KINASE
VARIANT
(Homo
sapiens) 		5 / 10 ASP A  60
SER A 190
TYR A 156
TYR A 189
VAL A 188
 None
 1.42A 4l6hA-4k0vA:
0.0		 4l6hA-4k0vA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 4k0v TEK TYROSINE KINASE
VARIANT
(Homo
sapiens) 		3 / 3 LYS A  95
TRP A  88
SER A  94
 None
 1.35A 5nwwA-4k0vA:
undetectable		 5nwwA-4k0vA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 4k0v TEK TYROSINE KINASE
VARIANT
(Homo
sapiens) 		4 / 6 GLY A 328
GLY A 308
PRO A 309
GLY A 292
 None
 0.63A 6ag0C-4k0vA:
undetectable		 6ag0C-4k0vA:
9.37