SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 4k12 COMPLEMENT FACTOR H
(Homo
sapiens) 		5 / 11 THR A  44
GLY A  45
THR A  40
GLY A  41
ASP A  56
 None
 1.32A 3t8nD-4k12A:
undetectable
3t8nF-4k12A:
undetectable		 3t8nD-4k12A:
14.50
3t8nF-4k12A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4k12 CHOLINE BINDING
PROTEIN A
(Streptococcus
pneumoniae) 		3 / 3 LEU B  38
VAL B  73
ASP B  74
 None
 0.49A 5x23A-4k12B:
undetectable		 5x23A-4k12B:
10.29