SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k1c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		4 / 8 GLN A 118
ASP A 276
VAL A 278
GLY A 273
 None
 0.91A 1ekjA-4k1cA:
undetectable
1ekjB-4k1cA:
undetectable		 1ekjA-4k1cA:
20.28
1ekjB-4k1cA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 118
ASP A 276
VAL A 278
GLY A 273
 None
 0.97A 1ekjC-4k1cA:
undetectable
1ekjD-4k1cA:
undetectable		 1ekjC-4k1cA:
20.28
1ekjD-4k1cA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 276
VAL A 278
GLY A 273
GLN A 118
 None
 0.94A 1ekjC-4k1cA:
undetectable
1ekjD-4k1cA:
undetectable		 1ekjC-4k1cA:
20.28
1ekjD-4k1cA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		3 / 3 ASN A  41
ALA A  76
ASN A  80
 None
 0.82A 1n4fA-4k1cA:
undetectable		 1n4fA-4k1cA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  97
ASN A  98
LEU A  96
ALA A  99
LEU A  78
 None
 1.12A 1ya3C-4k1cA:
undetectable		 1ya3C-4k1cA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 102
LEU A  97
THR A 100
ALA A  99
LEU A 219
 None
 1.31A 2npnA-4k1cA:
undetectable		 2npnA-4k1cA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 152
GLY A 145
ALA A 322
GLY A 320
ASN A 133
 None
 1.23A 3v3oB-4k1cA:
undetectable		 3v3oB-4k1cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		5 / 11 GLN A 152
GLY A 145
ALA A 322
GLY A 320
ASN A 133
 None
 1.11A 4a6nA-4k1cA:
undetectable		 4a6nA-4k1cA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 106
GLY A 298
SER A 129
 CA  A 506 ( 4.6A)
None
None
 0.70A 4b53B-4k1cA:
undetectable		 4b53B-4k1cA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 207
ALA A 330
GLN A 328
LEU A 208
LEU A 215
 None
 1.37A 4qzuA-4k1cA:
undetectable		 4qzuA-4k1cA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  97
LEU A 254
THR A  82
LEU A  85
 None
 0.47A 4z90F-4k1cA:
4.4
4z90G-4k1cA:
4.1
4z90H-4k1cA:
4.2
4z90I-4k1cA:
4.2
4z90J-4k1cA:
4.0		 4z90F-4k1cA:
22.27
4z90G-4k1cA:
22.27
4z90H-4k1cA:
22.27
4z90I-4k1cA:
22.27
4z90J-4k1cA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 133
ILE A 207
TYR A 211
PHE A 217
 None
 1.24A 5igvA-4k1cA:
undetectable		 5igvA-4k1cA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 258
LEU A 254
SER A 253
THR A  82
 None
 1.22A 5l4iB-4k1cA:
undetectable		 5l4iB-4k1cA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		4 / 8 ASN A  80
THR A 261
ILE A 256
GLY A 259
 None
 0.99A 5nzxA-4k1cA:
undetectable		 5nzxA-4k1cA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		4 / 7 ASN A  80
THR A 261
ILE A 256
GLY A 259
 None
 0.91A 5nzyA-4k1cA:
undetectable		 5nzyA-4k1cA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		5 / 12 SER A 200
VAL A 329
PHE A 352
VAL A 364
LEU A 127
 None
None
IOD  A 516 (-4.4A)
None
None
 1.21A 5tudD-4k1cA:
undetectable		 5tudD-4k1cA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4k1c VACUOLAR CALCIUM ION
TRANSPORTER
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  71
ASN A  67
ILE A 108
ILE A 111
LEU A 114
 None
 1.23A 5vkqC-4k1cA:
4.4
5vkqD-4k1cA:
4.4		 5vkqC-4k1cA:
14.10
5vkqD-4k1cA:
14.10