SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k1o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4k1o CATENIN ALPHA-2
(Mus
musculus) 		4 / 7 VAL A 856
SER A 857
ASP A 705
LYS A 861
 None
 1.33A 1hwiC-4k1oA:
undetectable		 1hwiC-4k1oA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4k1o CATENIN ALPHA-2
(Mus
musculus) 		4 / 7 VAL A 856
SER A 857
ASP A 705
LYS A 861
 None
 1.33A 1hwiD-4k1oA:
undetectable		 1hwiD-4k1oA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 4k1o CATENIN ALPHA-2
(Mus
musculus) 		3 / 3 ARG A 730
GLY A 733
PRO A 734
 None
 0.68A 2hreD-4k1oA:
undetectable		 2hreD-4k1oA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4k1o CATENIN ALPHA-2
(Mus
musculus) 		3 / 3 ARG A 754
GLY A 752
SER A 835
 None
 0.53A 2xctB-4k1oA:
undetectable		 2xctB-4k1oA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4k1o CATENIN ALPHA-2
(Mus
musculus) 		5 / 11 GLN A 765
ALA A 761
ALA A 759
THR A 831
LEU A 714
 None
 1.13A 4j6cA-4k1oA:
1.9		 4j6cA-4k1oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4k1o CATENIN ALPHA-2
(Mus
musculus) 		5 / 10 GLN A 765
ALA A 761
ALA A 759
THR A 831
LEU A 714
 None
 1.12A 4j6cB-4k1oA:
undetectable		 4j6cB-4k1oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4k1o CATENIN ALPHA-2
(Mus
musculus) 		5 / 12 GLN A 765
ALA A 761
ALA A 759
THR A 831
LEU A 714
 None
 1.13A 4j6dB-4k1oA:
undetectable		 4j6dB-4k1oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4k1o CATENIN ALPHA-2
(Mus
musculus) 		5 / 11 GLN A 765
ALA A 761
ALA A 759
THR A 831
LEU A 714
 None
 1.15A 4jbtB-4k1oA:
undetectable		 4jbtB-4k1oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 4k1o CATENIN ALPHA-2
(Mus
musculus) 		3 / 3 LYS A 716
LYS A 861
ALA A 702
 None
 1.07A 4ot2A-4k1oA:
3.7		 4ot2A-4k1oA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4k1o CATENIN ALPHA-2
(Mus
musculus) 		4 / 4 ASN A 790
MET A 722
MET A 725
TYR A 785
 None
 1.10A 5uc3B-4k1oA:
0.0		 5uc3B-4k1oA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4k1o CATENIN ALPHA-2
(Mus
musculus) 		3 / 3 LYS A 746
ASN A 790
SER A 793
 None
 1.28A 5yw0A-4k1oA:
undetectable		 5yw0A-4k1oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4k1o CATENIN ALPHA-2
(Mus
musculus) 		4 / 4 VAL A 856
GLY A 708
ASP A 710
ASP A 706
 None
 1.45A 6cjkC-4k1oA:
undetectable		 6cjkC-4k1oA:
24.22