SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4k1p NHEA
(Bacillus
cereus) 		4 / 4 THR A  20
LEU A  21
LEU A  28
GLN A  31
 None
 1.14A 1fbmA-4k1pA:
undetectable		 1fbmA-4k1pA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 4k1p NHEA
(Bacillus
cereus) 		3 / 3 GLU A 272
LYS A  49
VAL A  50
 None
 0.86A 1l2iA-4k1pA:
2.8		 1l2iA-4k1pA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 4k1p NHEA
(Bacillus
cereus) 		5 / 12 LEU A 233
ASN A 207
GLY A 231
GLN A 256
LEU A  34
 None
 1.43A 1nhzA-4k1pA:
undetectable		 1nhzA-4k1pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 4k1p NHEA
(Bacillus
cereus) 		4 / 4 LEU A 289
GLY A 185
ASP A 281
TYR A  38
 None
 1.01A 1oxrA-4k1pA:
undetectable		 1oxrA-4k1pA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4k1p NHEA
(Bacillus
cereus) 		5 / 12 ALA A 189
THR A 192
ALA A  37
ILE A 252
LEU A 259
 None
 1.04A 2nyrA-4k1pA:
undetectable		 2nyrA-4k1pA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 4k1p NHEA
(Bacillus
cereus) 		5 / 10 LEU A 300
GLU A 298
LEU A 138
MET A  85
LEU A  78
 None
 1.50A 2ocfA-4k1pA:
2.9		 2ocfA-4k1pA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 4k1p NHEA
(Bacillus
cereus) 		4 / 5 TYR A  88
ILE A 130
LEU A  21
LEU A 307
 None
 1.09A 2zb7A-4k1pA:
undetectable		 2zb7A-4k1pA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 4k1p NHEA
(Bacillus
cereus) 		5 / 11 VAL A  41
GLY A  39
ILE A  71
PRO A  33
SER A  32
 None
 1.26A 3bjwH-4k1pA:
undetectable		 3bjwH-4k1pA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 4k1p NHEA
(Bacillus
cereus) 		3 / 3 ARG A  87
ASP A 137
GLN A 136
 None
 0.57A 4azsA-4k1pA:
undetectable		 4azsA-4k1pA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4k1p NHEA
(Bacillus
cereus) 		4 / 6 LEU A 307
LEU A  21
ILE A  25
MET A  85
 None
 0.95A 4do3B-4k1pA:
undetectable		 4do3B-4k1pA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4k1p NHEA
(Bacillus
cereus) 		4 / 4 PRO A 261
LEU A 262
ILE A 183
ARG A 182
 None
 1.00A 4f4dA-4k1pA:
undetectable		 4f4dA-4k1pA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4k1p NHEA
(Bacillus
cereus) 		4 / 4 GLN A 346
THR A 347
LEU A 297
LEU A 300
 None
 1.32A 5m5kB-4k1pA:
undetectable		 5m5kB-4k1pA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 4k1p NHEA
(Bacillus
cereus) 		4 / 5 GLY A 185
SER A 285
TYR A  38
GLN A 188
 None
 0.92A 6ji6A-4k1pA:
undetectable		 6ji6A-4k1pA:
19.62