SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k1x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		4 / 6 LEU A 163
GLU A 164
TYR A  80
TYR A 189
 None
 1.34A 1qvuA-4k1xA:
undetectable		 1qvuA-4k1xA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		5 / 11 ARG A 203
ARG A 195
GLY A 129
THR A  30
THR A  28
 None
 1.49A 2eimG-4k1xA:
undetectable
2eimN-4k1xA:
0.2
2eimO-4k1xA:
undetectable		 2eimG-4k1xA:
14.74
2eimN-4k1xA:
17.84
2eimO-4k1xA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		5 / 12 PRO A 108
GLY A  47
LEU A 112
LEU A  77
SER A  70
 None
 1.26A 2nv4A-4k1xA:
3.8		 2nv4A-4k1xA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		5 / 12 PRO A 108
GLY A  47
LEU A 112
LEU A  77
SER A  70
 None
 1.34A 2nv4B-4k1xA:
3.8		 2nv4B-4k1xA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		3 / 3 PHE A 214
SER A 247
LEU A 245
 None
 0.82A 2w1bA-4k1xA:
undetectable		 2w1bA-4k1xA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		5 / 11 ILE A  96
LEU A 104
ILE A 102
SER A  70
PHE A  34
 None
 1.06A 2w9sB-4k1xA:
2.7		 2w9sB-4k1xA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		3 / 3 PHE A  44
SER A 137
SER A  70
 None
 1.01A 3ufgB-4k1xA:
undetectable		 3ufgB-4k1xA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		5 / 11 GLY A 129
THR A  30
THR A  28
ARG A 203
ARG A 195
 None
 1.50A 3x2qA-4k1xA:
undetectable
3x2qB-4k1xA:
undetectable
3x2qT-4k1xA:
undetectable		 3x2qA-4k1xA:
17.84
3x2qB-4k1xA:
24.55
3x2qT-4k1xA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		5 / 10 ARG A 203
ARG A 195
GLY A 129
THR A  30
THR A  28
 None
 1.48A 3x2qG-4k1xA:
undetectable
3x2qN-4k1xA:
undetectable
3x2qO-4k1xA:
undetectable		 3x2qG-4k1xA:
14.74
3x2qN-4k1xA:
17.84
3x2qO-4k1xA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		5 / 12 PHE A  34
LEU A 104
VAL A  50
ALA A  69
SER A  70
 None
 0.82A 4a84A-4k1xA:
undetectable		 4a84A-4k1xA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		3 / 3 THR A  41
PRO A 106
ASP A  17
 None
 0.81A 5l8dB-4k1xA:
undetectable		 5l8dB-4k1xA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		3 / 3 THR A  41
PRO A 106
ASP A  17
 None
 0.81A 5mwuB-4k1xA:
undetectable		 5mwuB-4k1xA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		7 / 9 SER A  67
THR A 130
GLY A 131
ALA A 133
CYH A 232
GLY A 233
GLU A 264
 FAD  A 301 (-3.1A)
FAD  A 301 (-2.8A)
None
FAD  A 301 (-3.5A)
None
None
FAD  A 301 (-2.9A)
 0.76A 5vw4A-4k1xA:
5.3		 5vw4A-4k1xA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		5 / 8 SER A  67
THR A 130
GLY A 131
CYH A 232
GLY A 233
 FAD  A 301 (-3.1A)
FAD  A 301 (-2.8A)
None
None
None
 0.61A 5vw5A-4k1xA:
20.7		 5vw5A-4k1xA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		5 / 10 ARG A 203
ARG A 195
GLY A 129
THR A  30
THR A  28
 None
 1.47A 5wauG-4k1xA:
undetectable
5waua-4k1xA:
0.2
5waub-4k1xA:
undetectable		 5wauG-4k1xA:
14.74
5waua-4k1xA:
17.84
5waub-4k1xA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 4k1x NADPH:FERREDOXIN
REDUCTASE
(Rhodobacter
capsulatus) 		3 / 3 ARG A 259
PHE A 261
GLY A 253
 None
 0.72A 6fgdA-4k1xA:
undetectable		 6fgdA-4k1xA:
21.14