SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3001_1
(SERUM ALBUMIN)		 4k22 PROTEIN VISC
(Escherichia
coli) 		5 / 11 ARG A 158
LEU A 159
ARG A 283
LEU A 316
ARG A 334
 None
 1.39A 1hk1A-4k22A:
undetectable		 1hk1A-4k22A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4k22 PROTEIN VISC
(Escherichia
coli) 		4 / 5 GLY A  21
GLN A  23
VAL A  29
SER A  25
 None
 1.25A 1p6kB-4k22A:
undetectable		 1p6kB-4k22A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k22 PROTEIN VISC
(Escherichia
coli) 		5 / 9 VAL A  31
LEU A  32
LEU A 170
GLY A 162
ALA A 163
 None
 1.28A 1pxxB-4k22A:
1.4		 1pxxB-4k22A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k22 PROTEIN VISC
(Escherichia
coli) 		5 / 10 VAL A  31
LEU A  32
LEU A 170
GLY A 162
ALA A 163
 None
 1.27A 1pxxD-4k22A:
1.4		 1pxxD-4k22A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4k22 PROTEIN VISC
(Escherichia
coli) 		4 / 5 GLY A  21
GLN A  23
VAL A  29
SER A  25
 None
 1.23A 1rs6B-4k22A:
undetectable		 1rs6B-4k22A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4k22 PROTEIN VISC
(Escherichia
coli) 		4 / 7 LEU A  22
ILE A   8
ILE A 127
ASP A   5
 None
 0.89A 1uwjA-4k22A:
undetectable		 1uwjA-4k22A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4k22 PROTEIN VISC
(Escherichia
coli) 		4 / 5 GLY A  21
GLN A  23
VAL A  29
SER A  25
 None
 1.20A 1zzqB-4k22A:
undetectable		 1zzqB-4k22A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4k22 PROTEIN VISC
(Escherichia
coli) 		4 / 5 GLY A  21
GLN A  23
VAL A  29
SER A  25
 None
 1.22A 1zzuA-4k22A:
undetectable		 1zzuA-4k22A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4k22 PROTEIN VISC
(Escherichia
coli) 		4 / 5 GLY A  21
GLN A  23
VAL A  29
SER A  25
 None
 1.25A 1zzuB-4k22A:
undetectable		 1zzuB-4k22A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 4k22 PROTEIN VISC
(Escherichia
coli) 		5 / 10 LEU A 284
GLY A 327
GLY A 162
LEU A 286
ALA A 280
 None
 1.00A 2v3kA-4k22A:
undetectable		 2v3kA-4k22A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4k22 PROTEIN VISC
(Escherichia
coli) 		5 / 12 GLY A  15
GLY A  12
LEU A 117
ASP A 164
LEU A 312
 None
 0.87A 2zbpA-4k22A:
undetectable		 2zbpA-4k22A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4k22 PROTEIN VISC
(Escherichia
coli) 		3 / 3 ALA A 314
ARG A 318
LYS A 324
 None
 1.02A 3kp5B-4k22A:
undetectable		 3kp5B-4k22A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4k22 PROTEIN VISC
(Escherichia
coli) 		4 / 6 LEU A  27
ALA A 157
ARG A 158
LEU A  22
 None
 1.12A 3rd0A-4k22A:
undetectable		 3rd0A-4k22A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4k22 PROTEIN VISC
(Escherichia
coli) 		5 / 12 LEU A 249
ILE A 192
GLN A 238
ALA A 265
SER A 264
 None
 1.36A 4a83A-4k22A:
undetectable		 4a83A-4k22A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4k22 PROTEIN VISC
(Escherichia
coli) 		4 / 4 LEU A 159
LEU A 170
GLN A 328
GLU A 144
 None
 1.13A 4i41A-4k22A:
undetectable		 4i41A-4k22A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4k22 PROTEIN VISC
(Escherichia
coli) 		5 / 12 ALA A  17
GLY A 288
GLY A 305
LEU A 304
TYR A 335
 None
 1.08A 4lg1A-4k22A:
3.2		 4lg1A-4k22A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4k22 PROTEIN VISC
(Escherichia
coli) 		5 / 12 ALA A  17
GLY A 288
GLY A 305
LEU A 304
TYR A 335
 None
 1.11A 4lg1B-4k22A:
3.2		 4lg1B-4k22A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4k22 PROTEIN VISC
(Escherichia
coli) 		5 / 12 ALA A  17
GLY A 288
GLY A 305
LEU A 304
TYR A 335
 None
 1.06A 4lg1C-4k22A:
3.1		 4lg1C-4k22A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4k22 PROTEIN VISC
(Escherichia
coli) 		4 / 6 ASP A 289
ASP A 308
SER A 342
ALA A 276
 None
 0.99A 4nedA-4k22A:
undetectable		 4nedA-4k22A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4k22 PROTEIN VISC
(Escherichia
coli) 		5 / 10 LEU A 347
LEU A 178
ALA A 166
ALA A 276
GLY A 273
 None
 1.47A 4rn6A-4k22A:
undetectable		 4rn6A-4k22A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4k22 PROTEIN VISC
(Escherichia
coli) 		5 / 12 ASP A   5
LEU A 135
LEU A  32
ALA A  30
THR A 148
 None
 1.24A 5nd3B-4k22A:
undetectable		 5nd3B-4k22A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4k22 PROTEIN VISC
(Escherichia
coli) 		3 / 3 GLU A 196
HIS A 221
ARG A 193
 None
 0.94A 5uunA-4k22A:
undetectable		 5uunA-4k22A:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4k22 PROTEIN VISC
(Escherichia
coli) 		4 / 5 GLY A  21
GLN A  23
VAL A  29
SER A  25
 None
 1.25A 5vunA-4k22A:
undetectable		 5vunA-4k22A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4k22 PROTEIN VISC
(Escherichia
coli) 		5 / 10 LEU A  22
VAL A  29
VAL A  18
ALA A 163
ALA A 285
 None
 1.09A 6h1lA-4k22A:
undetectable		 6h1lA-4k22A:
22.36