SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 366
GLY A 367
GLY A 142
ILE A 364
ALA A  37
 None
 0.97A 2fk8A-4k25A:
undetectable		 2fk8A-4k25A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 SER A 168
VAL A 179
SER A 323
VAL A 321
 None
 1.00A 2j9cA-4k25A:
undetectable
2j9cB-4k25A:
undetectable
2j9cC-4k25A:
undetectable		 2j9cA-4k25A:
16.18
2j9cB-4k25A:
16.18
2j9cC-4k25A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 178
PHE A 320
PHE A 349
 None
 0.78A 2od9A-4k25A:
undetectable		 2od9A-4k25A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 178
PHE A 320
PHE A 349
 None
 0.78A 2qqgA-4k25A:
undetectable		 2qqgA-4k25A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 147
GLY A 370
GLY A 142
THR A 113
 None
 0.77A 2wd9A-4k25A:
undetectable		 2wd9A-4k25A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 325
TYR A 353
LEU A 336
SER A 201
ILE A 300
 None
 1.03A 3frqB-4k25A:
undetectable		 3frqB-4k25A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 202
ILE A 299
GLY A 199
PHE A 257
 None
 0.88A 4dc3A-4k25A:
2.1		 4dc3A-4k25A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 ALA A  37
GLY A 142
ILE A 373
GLY A 370
 None
 0.63A 4eatA-4k25A:
undetectable		 4eatA-4k25A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 293
ILE A 224
GLU A 221
ILE A 287
 None
 0.95A 4mj8A-4k25A:
undetectable		 4mj8A-4k25A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 119
LEU A 122
HIS A 144
 None
 0.69A 4pevA-4k25A:
undetectable		 4pevA-4k25A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 175
HIS A 149
HIS A 145
 ZN  A 601 (-4.8A)
ZN  A 601 (-4.3A)
ZN  A 601 (-3.4A)
 0.96A 5oexA-4k25A:
undetectable		 5oexA-4k25A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 HIS A  86
HIS A 144
GLU A  39
ASP A 361
 None
None
None
ZN  A 601 (-2.1A)
 0.87A 6mn4D-4k25A:
undetectable		 6mn4D-4k25A:
21.27