SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k26'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1
(Mus
musculus) 		4 / 4 LEU A  71
VAL A  75
CYH A  78
ALA A  83
 None
 1.16A 1mz9E-4k26A:
undetectable		 1mz9E-4k26A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1
(Mus
musculus) 		5 / 12 SER A 195
PHE A 194
LEU A 118
LEU A 158
LEU A 155
 None
 1.35A 1p33C-4k26A:
24.4		 1p33C-4k26A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1
(Mus
musculus) 		5 / 12 LEU A  54
ALA A  83
ILE A 117
ILE A  38
LEU A  63
 None
 0.97A 1qknA-4k26A:
undetectable		 1qknA-4k26A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1
(Mus
musculus) 		5 / 10 ILE A 210
LEU A 116
ILE A 165
PHE A 194
THR A 249
 None
 1.20A 2w9sD-4k26A:
undetectable		 2w9sD-4k26A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1
(Mus
musculus) 		5 / 10 ILE A 210
LEU A 116
ILE A 165
PHE A 194
THR A 249
 None
 1.19A 2w9sF-4k26A:
undetectable		 2w9sF-4k26A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1
(Mus
musculus) 		3 / 3 PRO A 182
SER A 135
ASN A 143
 None
 0.83A 3lslG-4k26A:
undetectable		 3lslG-4k26A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1
(Mus
musculus) 		5 / 12 CYH A  78
LEU A  79
ALA A  83
MET A 110
ALA A  51
 None
 1.18A 3ut5D-4k26A:
2.4		 3ut5D-4k26A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1
(Mus
musculus) 		4 / 5 LEU A 155
PRO A 156
LEU A 158
ILE A 165
 None
 0.83A 4klrA-4k26A:
4.1		 4klrA-4k26A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1
(Mus
musculus) 		4 / 5 HIS A  53
VAL A  61
GLY A  58
ALA A  83
 None
 0.96A 5hwaA-4k26A:
undetectable		 5hwaA-4k26A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1
(Mus
musculus) 		5 / 12 ILE A 197
PHE A 194
ILE A 210
ALA A 153
LEU A 118
 None
 0.91A 5km9B-4k26A:
undetectable		 5km9B-4k26A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1
(Mus
musculus) 		4 / 7 THR A 211
ARG A 198
LEU A 116
SER A 146
 None
 1.25A 5uxcA-4k26A:
undetectable		 5uxcA-4k26A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1
(Mus
musculus) 		4 / 7 ARG A  48
TYR A  52
GLU A  49
GLU A 221
 SO4  A 303 ( 3.2A)
None
None
SO4  A 302 (-4.0A)
 1.30A 6mn5E-4k26A:
undetectable		 6mn5E-4k26A:
14.86