SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		5 / 12 GLY A 132
LEU A 215
LEU A 233
THR A 153
LEU A 185
 NAD  A 301 (-3.4A)
None
None
None
None
 1.42A 1jipA-4k28A:
undetectable		 1jipA-4k28A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		5 / 12 ILE A 131
GLY A 132
GLY A 134
ILE A 140
PRO A 196
 MN  A 302 (-4.6A)
NAD  A 301 (-3.4A)
NAD  A 301 (-3.2A)
None
NAD  A 301 (-4.5A)
 0.85A 1nv8B-4k28A:
7.0		 1nv8B-4k28A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		5 / 12 ILE A 131
GLY A 132
GLY A 134
ILE A 140
SER A 158
 MN  A 302 (-4.6A)
NAD  A 301 (-3.4A)
NAD  A 301 (-3.2A)
None
None
 0.96A 1sg9B-4k28A:
6.9		 1sg9B-4k28A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		5 / 12 ILE A 131
GLY A 132
ILE A 140
SER A 158
PRO A 196
 MN  A 302 (-4.6A)
NAD  A 301 (-3.4A)
None
None
NAD  A 301 (-4.5A)
 0.68A 1sg9B-4k28A:
6.9		 1sg9B-4k28A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		4 / 5 PRO A  22
ASN A  26
VAL A   9
ILE A  11
 None
 0.93A 1z2bC-4k28A:
undetectable		 1z2bC-4k28A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		4 / 6 LEU A 233
LEU A 234
ASP A 223
ILE A 131
 None
None
None
MN  A 302 (-4.6A)
 1.09A 2rlfB-4k28A:
undetectable
2rlfC-4k28A:
undetectable		 2rlfB-4k28A:
10.89
2rlfC-4k28A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		4 / 7 GLY A 111
ILE A 140
GLN A 245
LEU A 113
 None
 0.85A 2xrhA-4k28A:
undetectable		 2xrhA-4k28A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		5 / 10 PHE A 188
ILE A 131
ALA A 222
LEU A 185
PHE A 182
 None
MN  A 302 (-4.6A)
None
None
MN  A 302 (-4.7A)
 1.09A 3ay0A-4k28A:
6.5		 3ay0A-4k28A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		3 / 3 GLY A 134
ASP A 156
SER A 158
 NAD  A 301 (-3.2A)
NAD  A 301 (-2.7A)
None
 0.67A 3brfA-4k28A:
undetectable		 3brfA-4k28A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		5 / 12 ILE A 131
GLY A 132
ASP A 156
PRO A 157
ILE A 140
 MN  A 302 (-4.6A)
NAD  A 301 (-3.4A)
NAD  A 301 (-2.7A)
NAD  A 301 (-4.5A)
None
 0.88A 3jb1A-4k28A:
2.6		 3jb1A-4k28A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		5 / 12 GLY A 132
GLY A 134
ILE A 140
PRO A 196
VAL A 197
 NAD  A 301 (-3.4A)
NAD  A 301 (-3.2A)
None
NAD  A 301 (-4.5A)
None
 0.89A 4gc9A-4k28A:
undetectable		 4gc9A-4k28A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		4 / 6 PHE A 188
LEU A 207
ASN A 193
ARG A 127
 None
 1.42A 4yv5B-4k28A:
undetectable		 4yv5B-4k28A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		4 / 6 PHE A 188
LEU A 207
ASN A 193
ARG A 127
 None
 1.42A 4yv5A-4k28A:
undetectable		 4yv5A-4k28A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4k28 SHIKIMATE
DEHYDROGENASE FAMILY
PROTEIN
(Pseudomonas
putida) 		4 / 7 LEU A 233
GLU A 229
ILE A 140
VAL A 224
 None
None
None
NAD  A 301 (-4.0A)
 1.10A 5jh7C-4k28A:
2.0		 5jh7C-4k28A:
21.69