SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k29'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		4 / 8 GLY A 140
LEU A 137
SER A 242
GLY A 142
 None
 0.77A 1d0vA-4k29A:
undetectable		 1d0vA-4k29A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		4 / 8 GLY A 140
LEU A 137
SER A 242
GLY A 142
 None
 0.78A 1jhaA-4k29A:
undetectable		 1jhaA-4k29A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		5 / 12 LEU A  19
ALA A  45
ALA A  43
VAL A  54
TYR A   3
 None
 1.29A 1kt4A-4k29A:
undetectable		 1kt4A-4k29A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		5 / 12 ALA A 114
LEU A 117
ALA A 118
THR A 124
ILE A  53
 None
 1.10A 2jjpA-4k29A:
undetectable		 2jjpA-4k29A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		5 / 12 LEU A 111
GLY A 113
VAL A  92
LEU A 148
ILE A 143
 None
 1.36A 3h52A-4k29A:
undetectable		 3h52A-4k29A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		5 / 12 ILE A  53
ALA A 104
LEU A 117
LEU A  19
VAL A  52
 None
 1.15A 3ix9A-4k29A:
undetectable		 3ix9A-4k29A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		5 / 12 ILE A  53
ALA A 104
LEU A 117
LEU A  19
VAL A  52
 None
 1.17A 3ix9B-4k29A:
undetectable		 3ix9B-4k29A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		6 / 12 GLY A  58
ASP A 189
GLY A 108
ALA A 105
ALA A 104
CYH A 121
 None
 1.43A 3sufD-4k29A:
undetectable		 3sufD-4k29A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		3 / 3 LEU A 119
MET A  93
ASP A  88
 None
 0.83A 3v5wA-4k29A:
undetectable		 3v5wA-4k29A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		4 / 6 GLU A 238
GLY A 142
LEU A  85
GLU A 116
 None
 1.01A 3w9tB-4k29A:
undetectable		 3w9tB-4k29A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		4 / 6 GLU A 238
GLY A 142
LEU A  85
GLU A 116
 None
 1.00A 3w9tE-4k29A:
undetectable		 3w9tE-4k29A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		4 / 6 GLU A 238
GLY A 142
LEU A  85
GLU A 116
 None
 1.00A 3w9tF-4k29A:
undetectable		 3w9tF-4k29A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		3 / 3 LEU A 214
LYS A 211
THR A 210
 None
 0.60A 4lj0A-4k29A:
undetectable		 4lj0A-4k29A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4k29 ENOYL-COA
HYDRATASE/ISOMERASE
(Xanthobacter
autotrophicus) 		4 / 6 PHE A  61
VAL A  54
MET A  32
ILE A  36
 None
 1.14A 5iwuA-4k29A:
undetectable		 5iwuA-4k29A:
23.26