SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 12 TYR A 324
ASP A 425
GLY A 430
PHE A 419
VAL A  67
 None
 1.49A 1e3vA-4k2bA:
undetectable		 1e3vA-4k2bA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		3 / 3 GLU A 423
LYS A  66
VAL A  67
 None
 0.97A 1l2iA-4k2bA:
undetectable		 1l2iA-4k2bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 11 ILE A  76
HIS A 349
LEU A  70
PRO A 417
TYR A 378
 None
LLP  A 247 ( 4.5A)
None
None
None
 1.23A 1mrlA-4k2bA:
undetectable
1mrlB-4k2bA:
undetectable		 1mrlA-4k2bA:
19.82
1mrlB-4k2bA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 12 ILE A  76
HIS A 349
LEU A  70
PRO A 417
TYR A 378
 None
LLP  A 247 ( 4.5A)
None
None
None
 1.24A 1mrlB-4k2bA:
undetectable
1mrlC-4k2bA:
undetectable		 1mrlB-4k2bA:
19.82
1mrlC-4k2bA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 10 MET A 307
LEU A 304
ALA A 300
LEU A 103
LEU A 110
 None
 1.36A 1pcgB-4k2bA:
undetectable		 1pcgB-4k2bA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 10 LEU A 114
GLY A 226
ALA A 223
ILE A 129
GLY A 125
 None
None
None
None
LLP  A 247 ( 3.2A)
 1.02A 1t7iA-4k2bA:
undetectable		 1t7iA-4k2bA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		4 / 7 HIS A 407
LEU A 382
TYR A 379
ILE A 170
 None
 1.13A 1tuvA-4k2bA:
undetectable		 1tuvA-4k2bA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		4 / 5 LEU A 367
ASP A 362
LEU A 328
HIS A 433
 None
 1.30A 2jfaA-4k2bA:
undetectable		 2jfaA-4k2bA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		3 / 3 ARG A 323
GLU A  52
GLN A 327
 None
 0.93A 2p16A-4k2bA:
undetectable		 2p16A-4k2bA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		3 / 3 SER A 124
GLY A 125
THR A 126
 LLP  A 247 ( 3.7A)
LLP  A 247 ( 3.2A)
LLP  A 247 ( 3.6A)
 0.14A 3k9wA-4k2bA:
undetectable		 3k9wA-4k2bA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		4 / 4 GLY A 233
GLU A 221
ASP A 237
ASP A 231
 None
 1.12A 3mb5A-4k2bA:
3.3		 3mb5A-4k2bA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 12 GLY A 163
GLY A 141
ALA A 160
ALA A 157
LEU A 133
 None
 1.07A 3p2kC-4k2bA:
undetectable		 3p2kC-4k2bA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 12 LEU A 159
ALA A 160
ILE A 220
GLY A 132
LEU A 134
 None
 0.97A 3q95B-4k2bA:
undetectable		 3q95B-4k2bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		4 / 7 ARG A 426
GLU A 423
PHE A 419
PRO A 414
 None
 1.32A 3ql6A-4k2bA:
undetectable		 3ql6A-4k2bA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA598_0
(LACTOPEROXIDASE)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		4 / 5 ARG A 426
GLU A 423
PHE A 419
PRO A 414
 None
 1.32A 3r4xA-4k2bA:
undetectable		 3r4xA-4k2bA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		4 / 5 HIS A 202
THR A 230
GLU A 221
ASP A 237
 None
 1.43A 3tm4B-4k2bA:
undetectable		 3tm4B-4k2bA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		3 / 3 TYR A 215
GLU A 143
TYR A 189
 None
 0.93A 3ug8A-4k2bA:
undetectable		 3ug8A-4k2bA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		4 / 6 PHE A 243
ALA A 223
THR A 239
LEU A 114
 None
 0.95A 4ejgD-4k2bA:
undetectable		 4ejgD-4k2bA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		4 / 5 LEU A 415
ARG A 317
TRP A 348
ASN A 149
 None
 1.25A 4i00A-4k2bA:
undetectable		 4i00A-4k2bA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		4 / 8 LEU A 114
SER A 311
VAL A 251
GLY A 250
 None
None
None
LLP  A 247 ( 4.8A)
 1.00A 4klrB-4k2bA:
undetectable		 4klrB-4k2bA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 11 LEU A 159
ALA A 160
ILE A 220
GLY A 132
LEU A 134
 None
 0.92A 4pxmB-4k2bA:
undetectable		 4pxmB-4k2bA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 12 LEU A 159
ALA A 160
ILE A 220
GLY A 132
LEU A 134
 None
 0.93A 5gs4A-4k2bA:
undetectable		 5gs4A-4k2bA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 12 LEU A 159
ALA A 160
ILE A 220
GLY A 132
LEU A 134
 None
 1.11A 5gtrA-4k2bA:
undetectable		 5gtrA-4k2bA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 12 ASP A 296
GLY A 253
GLY A 303
LEU A 304
GLY A 125
 None
None
None
None
LLP  A 247 ( 3.2A)
 1.05A 5i71A-4k2bA:
undetectable		 5i71A-4k2bA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		3 / 3 LEU A 159
TYR A 395
SER A 383
 None
 0.89A 5iktA-4k2bA:
undetectable		 5iktA-4k2bA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 12 ILE A 170
SER A 152
ASN A 149
HIS A 407
LEU A 400
 None
 1.33A 6chgC-4k2bA:
undetectable		 6chgC-4k2bA:
15.62