SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		5 / 9 LEU A 116
TYR A 121
VAL A 109
GLY A 111
ALA A 112
 None
 1.18A 1pxxB-4k2hA:
undetectable		 1pxxB-4k2hA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		5 / 10 LEU A 116
TYR A 121
VAL A 109
GLY A 111
ALA A 112
 None
 1.18A 1pxxD-4k2hA:
undetectable		 1pxxD-4k2hA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		4 / 5 VAL A 141
GLY A 150
VAL A 142
TRP A 128
 None
 1.30A 1tkqB-4k2hA:
undetectable		 1tkqB-4k2hA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		6 / 12 CYH A 100
LEU A 163
THR A 162
ALA A  66
ASN A 146
ILE A  99
 None
 1.46A 3a35A-4k2hA:
undetectable		 3a35A-4k2hA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		6 / 12 CYH A 100
LEU A 163
THR A 162
ALA A  66
ASN A 146
ILE A  99
 None
 1.47A 3a35B-4k2hA:
undetectable		 3a35B-4k2hA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		3 / 3 ARG A  25
GLU A  32
THR A  33
 None
 0.77A 3v4tA-4k2hA:
undetectable		 3v4tA-4k2hA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		5 / 11 VAL A   6
LEU A   8
GLU A  16
ALA A  17
VAL A  68
 None
 1.15A 4e0fA-4k2hA:
undetectable		 4e0fA-4k2hA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		4 / 8 HIS A 155
PRO A 140
ASP A 158
TYR A 183
 None
 1.03A 4k0bB-4k2hA:
undetectable		 4k0bB-4k2hA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		4 / 8 HIS A 155
PRO A 140
ASP A 158
TYR A 183
 None
 1.03A 4l7iB-4k2hA:
undetectable		 4l7iB-4k2hA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		5 / 12 VAL A 122
TYR A 136
GLY A 154
SER A 104
ASP A 138
 None
 1.03A 4mm8A-4k2hA:
undetectable		 4mm8A-4k2hA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		5 / 10 VAL A  68
THR A  33
VAL A   4
LEU A   8
LEU A  24
 None
 1.04A 4yb6A-4k2hA:
undetectable
4yb6E-4k2hA:
undetectable		 4yb6A-4k2hA:
21.14
4yb6E-4k2hA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		5 / 10 VAL A  68
THR A  33
VAL A   4
LEU A   8
LEU A  24
 None
 1.05A 4yb6B-4k2hA:
undetectable
4yb6C-4k2hA:
undetectable		 4yb6B-4k2hA:
21.14
4yb6C-4k2hA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		5 / 10 LEU A   8
LEU A  24
VAL A  68
THR A  33
VAL A   4
 None
 1.03A 4yb6B-4k2hA:
undetectable
4yb6F-4k2hA:
undetectable		 4yb6B-4k2hA:
21.14
4yb6F-4k2hA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 4k2h INTRACELLULAR
PROTEASE/AMIDASE
(Salmonella
enterica) 		5 / 10 GLU A  16
GLY A  71
GLY A  72
ILE A 102
GLY A 152
 None
 0.40A 6e5zA-4k2hA:
30.0		 6e5zA-4k2hA:
31.66