SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE
(Magnetospirillum
magneticum) 		5 / 12 PHE A  -2
LEU A   7
ILE A  52
ALA A  14
VAL A  50
 None
 1.10A 1cbsA-4k2nA:
undetectable		 1cbsA-4k2nA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE
(Magnetospirillum
magneticum) 		4 / 6 PHE A 131
ILE A 150
LYS A 177
ALA A 174
 None
 1.16A 1hk2A-4k2nA:
undetectable		 1hk2A-4k2nA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE
(Magnetospirillum
magneticum) 		4 / 6 TYR A  83
VAL A 140
ILE A 135
LEU A  91
 None
 1.20A 1j96A-4k2nA:
undetectable		 1j96A-4k2nA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE
(Magnetospirillum
magneticum) 		3 / 3 GLU A 146
GLU A 115
TRP A  32
 None
 1.26A 3hrdA-4k2nA:
undetectable
3hrdE-4k2nA:
undetectable
3hrdF-4k2nA:
undetectable		 3hrdA-4k2nA:
22.22
3hrdE-4k2nA:
22.22
3hrdF-4k2nA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE
(Magnetospirillum
magneticum) 		5 / 11 ASN A  25
GLY A 112
ALA A  36
GLY A  34
GLU A  40
 None
 1.35A 4a6nA-4k2nA:
undetectable		 4a6nA-4k2nA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE
(Magnetospirillum
magneticum) 		5 / 11 ASN A  25
GLY A 113
ALA A  36
GLY A  34
GLU A  40
 None
 1.33A 4a6nA-4k2nA:
undetectable		 4a6nA-4k2nA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE
(Magnetospirillum
magneticum) 		5 / 10 ALA A 103
LEU A  53
ILE A  42
ALA A  38
ALA A  90
 None
 0.79A 4j14A-4k2nA:
undetectable		 4j14A-4k2nA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE
(Magnetospirillum
magneticum) 		5 / 10 LEU A  53
ILE A  42
ALA A  38
ALA A  90
THR A  93
 None
 1.10A 4j14A-4k2nA:
undetectable		 4j14A-4k2nA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE
(Magnetospirillum
magneticum) 		5 / 9 VAL A 183
ILE A 150
VAL A 153
ALA A 154
ALA A 175
 None
 1.01A 4oqrA-4k2nA:
undetectable		 4oqrA-4k2nA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE
(Magnetospirillum
magneticum) 		4 / 5 ALA A 148
ARG A  95
ALA A 143
GLU A 115
 None
 1.16A 5a06C-4k2nA:
2.4
5a06D-4k2nA:
2.7		 5a06C-4k2nA:
23.33
5a06D-4k2nA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE
(Magnetospirillum
magneticum) 		3 / 3 ASP A 190
GLU A  10
SER A 128
 None
 0.78A 5bw4B-4k2nA:
undetectable		 5bw4B-4k2nA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4k2n ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE
(Magnetospirillum
magneticum) 		6 / 12 PHE A  39
GLY A  55
GLY A  34
ALA A  36
PHE A  61
THR A  93
 None
 1.37A 5w4zA-4k2nA:
undetectable		 5w4zA-4k2nA:
15.77