SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4k2p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ALA A 643
GLU A 612
LEU A 665
ARG A 669
ILE A 656
 None
 1.33A 1a52A-4k2pA:
undetectable		 1a52A-4k2pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ALA A 643
GLU A 612
LEU A 665
ARG A 669
ILE A 656
 None
 1.32A 1a52B-4k2pA:
undetectable		 1a52B-4k2pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		6 / 12 LEU A 639
ALA A 643
GLU A 612
MET A 651
VAL A 666
ARG A 669
 None
 1.46A 1s9pC-4k2pA:
undetectable		 1s9pC-4k2pA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		3 / 3 SER A 644
HIS A 663
ASP A 523
 None
 0.70A 2oxtA-4k2pA:
undetectable		 2oxtA-4k2pA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		4 / 5 HIS A 543
CYH A 623
ILE A 501
LEU A 633
 None
 1.39A 3qpkA-4k2pA:
undetectable		 3qpkA-4k2pA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		3 / 3 PHE A 445
SER A 658
SER A 660
 None
 0.93A 3ufgB-4k2pA:
undetectable		 3ufgB-4k2pA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A 456
LEU A 521
GLY A 522
ALA A 664
LEU A 665
 None
 1.12A 4coxA-4k2pA:
undetectable		 4coxA-4k2pA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A 456
LEU A 521
GLY A 522
ALA A 664
LEU A 665
 None
 1.12A 4coxB-4k2pA:
undetectable		 4coxB-4k2pA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A 456
LEU A 521
GLY A 522
ALA A 664
LEU A 665
 None
 1.12A 4coxD-4k2pA:
undetectable		 4coxD-4k2pA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 471
CYH A 472
HIS A 543
TYR A 624
LEU A 517
 None
 1.43A 4emaA-4k2pA:
0.9		 4emaA-4k2pA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 655
SER A 661
LEU A 640
LEU A 526
LEU A 446
 None
 1.35A 4emaA-4k2pA:
0.9		 4emaA-4k2pA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A 456
LEU A 521
GLY A 522
ALA A 664
LEU A 665
 None
 1.05A 4rrwD-4k2pA:
undetectable		 4rrwD-4k2pA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A 456
LEU A 521
GLY A 522
ALA A 664
LEU A 665
 None
 1.05A 4rrzD-4k2pA:
undetectable		 4rrzD-4k2pA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 563
PHE A 621
LEU A 570
VAL A 550
ASN A 499
 None
 1.26A 6ftpA-4k2pA:
undetectable
6ftpB-4k2pA:
undetectable		 6ftpA-4k2pA:
14.86
6ftpB-4k2pA:
9.80